Author: "A Linder" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

4,191 results on '"A Linder"'

1. Social interactions in the metaverse: Framework, initial evidence, and research roadmap

Author: Hennig-Thurau, Thorsten, Aliman, Dorothea N., Herting, Alina M., Cziehso, Gerrit P., Linder, Marc, and Kübler, Raoul V.
Subjects: Real-time systems -- Usage -- Social aspects, Interpersonal relations -- Models, Human-machine systems -- Usage -- Social aspects, Virtual worlds -- Usage -- Social aspects, Real-time control -- Usage -- Social aspects, Real-time system, Advertising, marketing and public relations, Business
Abstract: Real-time multisensory social interactions (RMSIs) between people are at the center of the metaverse, a new computer-mediated environment consisting of virtual 'worlds' in which people act and communicate with each other in real-time via avatars. This research investigates whether RMSIs in the metaverse, when accessed through virtual-reality headsets, can generate more value for interactants in terms of interaction outcomes (interaction performance, evaluation, and emotional responses) than those on the two-dimensional (2D) internet (e.g., Zoom meetings). We combine theoretical logic with extensive field-experimental probes (which support the value-creation potential of the virtual-reality metaverse, but contradict its general superiority) to develop and refine a framework of how RMSIs in the metaverse versus on the 2D internet affect interaction outcomes through interactants' intermediate conditions. The refined framework serves as foundation for a research roadmap on RMSIs in the metaverse, in which we highlight the critical roles of specific mediating and moderating forces along with interactional formats for future investigations of the metaverse and also name key business areas and societal challenges that deserve scholarly attention., Author(s): Thorsten Hennig-Thurau [sup.1] , Dorothea N. Aliman [sup.1] , Alina M. Herting [sup.1] , Gerrit P. Cziehso [sup.1] , Marc Linder [sup.1] , Raoul V. Kübler [sup.2] Author Affiliations: [...]
Published: 2023
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2. How Richard J. Linder Founded Xenter: And melded digital and medical technologies to create 'smart' medical devices

Author: Linder, Richard J.
Subjects: Johnson & Johnson, Medical equipment, Physiological apparatus, Business, Business, regional, University of Southern California
Abstract: 'HE MAY NOT MAKE IT ANOTHER DAY.' I wasn't fully alert when the doctors gave that bad news to my wife, Marla. At the time, I was in an ICU [...]
Published: 2023

3. PW TALKS WITH CHARLES DUHIGG: Across the Aisle: In Supercommunicators (Random House, Feb.; reviewed on p. 79), Duhigg breaks down the roadblocks to productive dialogue and the skills needed to surmount them

Author: Linder, Ben
Subjects: Advertising, marketing and public relations, Business, Publishing industry
Abstract: Why is it difficult to think about communication as a skill? We're raised to think of people as being good communicators or bad communicatots as if it's an innate trait, [...]
Published: 2023

4. How do non-innovative firms start innovation and build legitimacy? The case of professional service firms

Author: Elisa Villani, Christian Lechner, Christian Linder, Lina Muller, Villani E., Linder C., Lechner C., and Muller L.
Subjects: media_common.quotation_subject, Face (sociological concept), ComputingMilieux_LEGALASPECTSOFCOMPUTING, Process innovation, Service innovation, Legitimacy, Industrial organization, media_common, Marketing, Qualitative comparative analysi, ComputingMilieux_THECOMPUTINGPROFESSION, Qualitative comparative analysis, Competitor analysis, Law firms, Law firms, Legitimacy, Process innovation, Professional service firms, Qualitative comparative analysis, Service innovation, Law firm, ComputingMilieux_GENERAL, Multinational corporation, Service (economics), Professional service firm, Business, Professional service firms
Abstract: As clients’ needs change, firms need to adapt and innovate, but how do firms innovate if they have not done it before? We study law firms as novice innovators. Law firms are generally conservative and averse to exploration-based innovation. We show that law firms face two challenges in starting innovation: developing innovation capacity and gaining legitimacy for innovative behavior. Employing a qualitative comparative analysis approach, we used 50 in-depth interviews with innovating multinational law firms headquartered in the United Kingdom to present six configurations of factors leading to service innovation in law firms. Clients and competitors play a key role both as innovation stimuli and legitimizing actors. We demonstrate that knowledge-based networks are important for service innovation, but legitimizing strategies are important for novice innovators to ensure innovation is recognized, approved, and diffused.
Published: 2021
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5. Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study

Author: Monique de Waart, Anina Enderli, Ferdy S van Geest, Adri van der Walt, Krishna Chatterjee, Sjoerd A A van den Berg, Laura Paone, Patricia Crock, Anne-Marie van Wermeskerken, Lilla Szeifert, Francesco Porta, D Barca, Carla Moran, Katalin E Müller, Alice Dica, Athanasia Stoupa, Felipe Monti Lora, Dana Craiu, Hans van Toor, Peter Christian, Amnon Zung, Stefan Groeneweg, W. Edward Visser, Ronald van der Wal, Régis Coutant, Luigi Garibaldi, Marco Spada, Joel Vanderniet, Jolanta Wierzba, Tony Huynh, Greta Lyons, Annette Hackenberg, Gerarda Cappuccio, Serap Turan, Michaela Linder-Lucht, Jan Fairchild, Peter J Simm, Yolanda B. de Rijke, Enrico Bertini, Amy Lawson-Yuen, Erica L T van den Akker, Bianka Heinrich, Nicola Brunetti-Pierri, Michel Polak, Cheyenne Dewey, Rachana Dubey, Christina Reinauer, Praveen G. Paul, Belinda George, Doris Brunner, Robin P. Peeters, Paul Dimitri, Marco Cappa, Anna Simon, Federica Zibordi, Tuba Seven Menevse, Jonathan Gallichan, Anna Kłosowska, Rowen Seckold, Iuliu Bacos, Davide Tonduti, Alexander D Chesover, Internal Medicine, Pediatrics, Clinical Chemistry, van Geest, Ferdy S, Groeneweg, Stefan, van den Akker, Erica L T, Bacos, Iuliu, Barca, Diana, van den Berg, Sjoerd A A, Bertini, Enrico, Brunner, Dori, Brunetti-Pierri, Nicola, Cappa, Marco, Cappuccio, Gerarda, Chatterjee, Krishna, Chesover, Alexander D, Christian, Peter, Coutant, Régi, Craiu, Dana, Crock, Patricia, Dewey, Cheyenne, Dica, Alice, Dimitri, Paul, Dubey, Rachana, Enderli, Anina, Fairchild, Jan, Gallichan, Jonathan, Garibaldi, Luigi R, George, Belinda, Hackenberg, Annette, Heinrich, Bianka, Huynh, Tony, Kłosowska, Anna, Lawson-Yuen, Amy, Linder-Lucht, Michaela, Lyons, Greta, Lora, Felipe Monti, Moran, Carla, Müller, Katalin E, Paone, Laura, Paul, Praveen G, Polak, Michel, Porta, Francesco, Reinauer, Christina, de Rijke, Yolanda B, Seckold, Rowen, Menevşe, Tuba Seven, Simm, Peter, Simon, Anna, Spada, Marco, Stoupa, Athanasia, Szeifert, Lilla, Tonduti, Davide, van Toor, Han, Turan, Serap, Vanderniet, Joel, de Waart, Monique, van der Wal, Ronald, van der Walt, Adri, van Wermeskerken, Anne-Marie, Wierzba, Jolanta, Zibordi, Federica, Zung, Amnon, Peeters, Robin P, and Visser, W Edward
Subjects: Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, chemistry.chemical_compound, Endocrinology, Clinical endpoint, MCT8 Deficiency, Child, Symporters, Thyroid, Middle Aged, Muscular Atrophy, Treatment Outcome, medicine.anatomical_structure, Child, Preschool, Muscle Hypotonia, Triiodothyronine, Female, Adult, Monocarboxylic Acid Transporters, medicine.medical_specialty, Adolescent, Context (language use), AHDS, Young Adult, SDG 3 - Good Health and Well-being, Internal medicine, Heart rate, medicine, Humans, Allan-Herndon-Dudley syndrome, Aged, Retrospective Studies, Creatinine, Allan–Herndon–Dudley syndrome, T3 analogue, business.industry, Biochemistry (medical), Infant, Retrospective cohort study, medicine.disease, chemistry, Mutation, Mental Retardation, X-Linked, business, thyromimetic drug, Follow-Up Studies, Hormone
Abstract: Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated with being underweight and having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical and biochemical features during 1-year treatment with the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated the efficacy of Triac in MCT8-deficient patients in 33 sites. The primary endpoint was change in serum T3 concentrations from baseline to last available measurement. Secondary endpoints were changes in other thyroid parameters, anthropometric parameters, heart rate, and biochemical markers of thyroid hormone action. Results From October 15, 2014 to January 1, 2021, 67 patients (median baseline age 4.6 years; range, 0.5-66) were treated up to 6 years (median 2.2 years; range, 0.2-6.2). Mean T3 concentrations decreased from 4.58 (SD 1.11) to 1.66 (0.69) nmol/L (mean decrease 2.92 nmol/L; 95% CI, 2.61-3.23; P < 0.0001; target 1.4-2.5 nmol/L). Body-weight-for-age exceeded that of untreated historical controls (mean difference 0.72 SD; 95% CI, 0.36-1.09; P = 0.0002). Heart-rate-for-age decreased (mean difference 0.64 SD; 95% CI, 0.29-0.98; P = 0.0005). SHBG concentrations decreased from 245 (99) to 209 (92) nmol/L (mean decrease 36 nmol/L; 95% CI, 16-57; P = 0.0008). Mean creatinine concentrations increased from 32 (11) to 39 (13) µmol/L (mean increase 7 µmol/L; 95% CI, 6-9; P < 0.0001). Mean creatine kinase concentrations did not significantly change. No drug-related severe adverse events were reported. Conclusions Key features were sustainably alleviated in patients with MCT8 deficiency across all ages, highlighting the real-life potential of Triac for MCT8 deficiency.
Published: 2021
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6. A Contemporary Analysis of Ureteral Reconstruction 30-Day Morbidity Utilizing the National Surgical Quality Improvement Program Database: Comparison of Minimally Invasive vs Open Approaches

Author: Boyd R. Viers, Matthew T. Gettman, Kevin Hebert, Matthew Ziegelmann, Timothy D. Lyon, Brian J. Linder, Daniel S. Ubl, and Elizabeth B. Habermann
Subjects: Database, business.industry, Urology, Odds ratio, Logistic regression, computer.software_genre, Ureteral reconstruction, Acs nsqip, Invasive surgery, Medicine, Postoperative outcome, Major complication, Complication, business, computer
Abstract: OBJECTIVES To characterize 30-day morbidity of upper ureteral reconstruction (UUR) and lower ureteral reconstruction (LUR) surgery by comparing open and minimally invasive surgery (MIS) approaches using a national surgical outcomes registry. METHODS The American College of Surgeons National Surgical Quality Improvement Program database was reviewed for patients who underwent UUR and LUR between 2007-2017. Primary endpoints included 30-day complications, transfusion, readmission, return to operating room (ROR), and prolonged postoperative length of stay (LOS). Multivariable logistic regression was performed to observe the association of MIS approach on 30-day outcomes. RESULTS 3042 patients were identified with 2116 undergoing UUR and 926 undergoing LUR. Of 2116 patients undergoing UUR, 1733 (82%) were performed via MIS approach. On multivariable analysis, open approach for UUR was associated with increased odds of any 30-day complication (odds ratio (OR) 1.6 [1.1-2.4]; p=0.014), major complication (OR 1.8 [1.04-3.0]; p=0.034), transfusion (OR 3.7 [1.2- 11.5]; p=0.025), ROR (OR 2.0 [1.0-3.9]; p=0.047), and prolonged LOS (OR 5.4 [3.9-7.6]; p
Published: 2022
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7. Patient characteristics and safety outcomes in new users of ticagrelor and clopidogrel—An observational cohort study in Sweden

Author: Morten Andersen and Marie Linder
Subjects: Male, safety, Ticagrelor, medicine.medical_specialty, Acute coronary syndrome, Epidemiology, medicine.medical_treatment, ticagrelor, Cohort Studies, Percutaneous Coronary Intervention, Internal medicine, cohort study, medicine, Humans, Pharmacology (medical), Myocardial infarction, Acute Coronary Syndrome, patient characteristics, Aged, Sweden, clopidogrel, business.industry, Incidence (epidemiology), Percutaneous coronary intervention, medicine.disease, Clopidogrel, Confidence interval, Treatment Outcome, Female, business, Platelet Aggregation Inhibitors, medicine.drug, Cohort study
Abstract: Purpose We aimed to describe characteristics of new users of ticagrelor or clopidogrel following a recent coronary event, and to compare incidences of selected safety outcomes. Methods This observational cohort study used data from national Swedish registers. Patients first dispensed ticagrelor or clopidogrel (June 2011-December 2013) were identified from the Prescribed Drug Register and followed until censoring or 31 December 2014. Cohorts were restricted to patients with a recent coronary event-related hospital contact identified in the Patient Register. Results The study included 45 987 unique, naive users of ticagrelor (73% men; mean age 66 years) or clopidogrel (69% men; mean age 69 years). Corresponding to indication, diagnoses before initiation were acute coronary syndrome (93%), myocardial infarction (76%), and percutaneous coronary intervention (69%). The most common medications used in the year before initiation of study therapy were antithrombotic agents (clopidogrel 62%, ticagrelor 43%), mainly low-dose acetylsalicylic acid. Ticagrelor users had a higher incidence (per 1000 person-years) of respiratory bleeding (24.6 [95% confidence interval (CI): 22.1-27.3]; vs clopidogrel users: 14.4 [13.1-15.8]) and dyspnea (25.9 [23.3-28.7]; vs clopidogrel users: 16.8 [15.4-18.4]). Epistaxis accounted for 83-93% of respiratory bleeds. Adjusted analyses found increased risks of gout and acute renal failure with ticagrelor. Conclusions Clopidogrel users were older with a higher prevalence of concomitant medications than ticagrelor users. Our study showed increased incidences of dyspnea and respiratory bleeding (mainly epistaxis) among current ticagrelor users compared with clopidogrel users, and increased risks of gout and acute renal failure after adjustment. This article is protected by copyright. All rights reserved.
Published: 2021
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8. Effects of Platform EMI in Synchronized Cooperative Broadcast Systems

Author: Ulf Sterner, Jan Anders Nilsson, Sara Linder, and Karina Fors
Subjects: Computer science, EMI, business.industry, Electrical and Electronic Engineering, Condensed Matter Physics, business, Atomic and Molecular Physics, and Optics, Computer network
Published: 2021
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9. The effect of virtual reality on temporal bone anatomy evaluation and performance

Author: Antti Lehtimäki, Antti-Pekka Elomaa, Heikki Löppönen, Matti Iso-Mustajärvi, Aarno Dietz, Pia Linder, and Tomi Timonen
Subjects: medicine.medical_specialty, 020205 medical informatics, Anatomical structures, Computed tomography, 02 engineering and technology, Virtual reality, Surgical planning, User-Computer Interface, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, Computer Simulation, 030223 otorhinolaryngology, Preoperative planning, medicine.diagnostic_test, business.industry, Virtual Reality, Temporal Bone, General Medicine, Expert group, Cross-Sectional Studies, Otorhinolaryngology, Temporal bone anatomy, Clinical Competence, business, Fiducial marker
Abstract: Purpose There is only limited data on the application of virtual reality (VR) for the evaluation of temporal bone anatomy. The aim of the present study was to compare the VR environment to traditional cross-sectional viewing of computed tomography images in a simulated preoperative planning setting in novice and expert surgeons. Methods A novice (n = 5) and an expert group (n = 5), based on their otosurgery experience, were created. The participants were asked to identify 24 anatomical landmarks, perform 11 distance measurements between surgically relevant anatomical structures and 10 fiducial markers on five cadaver temporal bones in both VR environment and cross-sectional viewings in PACS interface. The data on performance time and user-experience (i.e., subjective validation) were collected. Results The novice group made significantly more errors (p p = 0.001) in cross-sectional viewing than the expert group. In the VR environment, there was no significant differences (errors and time) between the groups. The performance of novices improved faster in the VR. The novices showed significantly faster task performance (p = 0.003) and a trend towards fewer errors (p = 0.054) in VR compared to cross-sectional viewing. No such difference between the methods were observed in the expert group. The mean overall scores of user-experience were significantly higher for VR than cross-sectional viewing in both groups (p Conclusion In the VR environment, novices performed the anatomical evaluation of temporal bone faster and with fewer errors than in the traditional cross-sectional viewing, which supports its efficiency for the evaluation of complex anatomy.
Published: 2021
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10. Government websites as data: a methodological pipeline with application to the websites of municipalities in the United States

Author: Fridolin Linder, Markus Neumann, and Bruce A. Desmarais
Subjects: Topic model, Government, Public Administration, Sociology and Political Science, General Computer Science, business.industry, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Public relations, business, Pipeline (software)
Abstract: The content of a government’s website is an important source of information about policy priorities, procedures, and services. Existing research on government websites has relied on manual methods ...
Published: 2021
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11. Multicenter Results With an Active Transcutaneous Bone Conduction Implant in Patients With Single-sided Deafness

Author: Bernd Strauchmann, Wilhelm Wimmer, Marlene Pollotzek, Frauke Hanke, Thomas Linder, Marco Caversaccio, John-Martin Hempel, Nicola De Min, Henning Frenzel, Alexander Huber, Christof Röösli, and University of Zurich
Subjects: Adult, medicine.medical_specialty, Hearing Loss, Sensorineural, medicine.medical_treatment, Clinical Neurology, 10045 Clinic for Otorhinolaryngology, 610 Medicine & health, Deafness, Sensorineural deafness, Audiology, Hearing Loss, Unilateral, Prosthetic Devices, Hearing Aids, Bone conduction, Single sided deafness, otorhinolaryngologic diseases, Humans, Medicine, In patient, Prospective Studies, Rehabilitation, business.industry, Significant difference, Implant, Repeated measures design, medicine.disease, Sensory Systems, Treatment Outcome, Otorhinolaryngology, Speech Perception, Sensorineural hearing loss, Neurology (clinical), business
Abstract: Objective: To evaluate the audiological and subjective benefit from hearing rehabilitation with an active bone conduction implant in subjects with single-sided sensorineural deafness (SSD). Study design: Prospective, multicenter, single-subject repeated measures. Setting: Tertiary referral center, five clinics in Germany and Switzerland. Patients: Seventeen subjects aged 18 years and older with severe to profound unilateral sensorineural hearing loss and contralateral normal hearing were followed up for 24 months. Intervention: Active bone conduction implant. Main outcome measures: Speech understanding in noise was assessed in three situations: with signal from front, deaf, or normal hearing side (with noise from front in all set-ups). Subjective benefit was evaluated using the Speech, Spatial, and Qualities of Hearing (SSQ-B) and Bern Benefit in Single-Sided Deafness (BBSS) questionnaire. Results: When the signal was coming from the deaf side the mean improvement of the speech reception threshold in noise ranged from 1.5 up to 2.2 dB with the device and was statistically and clinically significant at all tested timepoints. No significant difference between the aided and unaided situation was found when signal and noise were coming from the front. With the signal from the normal hearing side no clinically significant difference, that is, greater than 1 dB between the aided and unaided situation was found. The SSQ-B and BBSS questionnaire showed an overall improvement with no significant difference between time points. Conclusions: The study demonstrates long-term efficacy and benefit of the device in adults with SSD. Patients reported substantial and persistent subjective benefit from the active bone conduction implant.
Published: 2021
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12. Impact of Order-Set Modifications and Provider Education Following Guideline Updates on Broad-Spectrum Antibiotic Use in Patients Admitted With Community Acquired Pneumonia

Author: Casey J. Dempsey, Kristin E Linder, Jessica L. Colmerauer, Anastasia Bilinskaya, David P. Nicolau, and Joseph L. Kuti
Subjects: Pharmacology, medicine.medical_specialty, business.industry, Pharmacy, Guideline, medicine.disease, Broad spectrum, Pneumonia, Community-acquired pneumonia, Physician prescribing, medicine, Anti infectives, Pharmacology (medical), In patient, Intensive care medicine, business, Order set
Abstract: Purpose: Following updates to the Infectious Diseases Society of America (IDSA) practice guidelines for the Diagnosis and Treatment of Adults with Community-acquired Pneumonia in 2019, Hartford HealthCare implemented changes to the community acquired pneumonia (CAP) order-set in August 2020 to reflect criteria for the prescribing of broad-spectrum antimicrobial therapy. The objective of the study was to evaluate changes in broad-spectrum antibiotic days of therapy (DOT) following these order-set updates with accompanying provider education. Methods: This was a multi-center, quasi-experimental, retrospective study of patients with a diagnosis of CAP from September 1, 2019 to October 31, 2019 (pre-intervention) and September 1, 2020 to October 31, 2020 (post-intervention). Patients were identified using ICD-10 codes (A48.1, J10.00-J18.9) indicating lower respiratory tract infection. Data collected included demographics, labs and vitals, radiographic, microbiological, and antibiotic data. The primary outcome was change in broad-spectrum antibiotic DOT, specifically anti-pseudomonal β-lactams and anti-MRSA antibiotics. Secondary outcomes included guideline-concordance of initial antibiotics, utilization of an order-set to prescribe antibiotics, and length of stay (LOS). Results: A total of 331 and 352 patients were included in the pre- and post-intervention cohorts, respectively. There were no differences in order-set usage (10% vs 11.3%, P = .642) between the pre- and post-intervention cohort, respectively. The overall duration of broad-spectrum therapy was a median of 2 days (IQR 0-8 days) in the pre-intervention period and 0 days (IQR 0-4 days) in the post-intervention period ( P
Published: 2021
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13. Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa

Author: Musie Ghebremichael, Tilo Winkler, Antonella C Lisanti-Park, Benjamin D. Medoff, Samantha J Gates, Douglas S. Kwon, Josalyn L. Cho, R. Scott Harris, Björn Corleis, Puja Kohli, Alice H Linder, Amy Dickey, and Abigail E Schiff
Subjects: Pulmonary and Respiratory Medicine, Chemokine, biology, medicine.diagnostic_test, business.industry, T cell, Clinical Biochemistry, T cell chemotaxis, virus diseases, Cell Biology, respiratory system, CCL5, respiratory tract diseases, medicine.anatomical_structure, Bronchoalveolar lavage, Immunology, medicine, biology.protein, CXCL10, Cytotoxic T cell, business, Molecular Biology, CD8
Abstract: Smoking and HIV-1 infection are risk factors for COPD, which is among the most common comorbid conditions in people living with HIV-1. HIV-1 infection leads to persistent expansion of CD8+ T cells, and CD8+ T cell-mediated inflammation has been implicated in COPD pathogenesis. In this study, we investigated the effects of HIV-1 infection and smoking on T cell dynamics in patients at risk of COPD. Bronchoalveolar lavage (BAL), endobronchial brushings and blood from HIV-1 infected and uninfected non-smokers and smokers were analyzed by flow cytometry, and lungs were imaged by computed tomography. Chemokines were measured in BAL fluid, and CD8+ T cell chemotaxis in the presence of cigarette smoke extract was assessed in vitro. HIV-1 infection increased CD8+ T cells in the BAL, but this increase was abrogated by smoking. Smokers had reduced BAL levels of the T cell-recruiting chemokines CXCL10 and CCL5, and cigarette smoke extract inhibited CXCL10 and CCL5 production by macrophages and CD8+ T cell transmigration in vitro. In contrast to the BAL, CD8+ T cells in endobronchial brushings were increased in HIV-1 infected smokers, driven by an accumulation of effector memory T cells in the airway mucosa and an increase in tissue resident memory T cells. Mucosal CD8+ T cell numbers inversely correlated with lung aeration, suggesting an association with inflammation and remodeling. HIV-1 infection and smoking lead to retention of CD8+ T cells within the airway mucosa.
Published: 2021
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14. Postoperative Opioid Prescribing After Female Pelvic Medicine and Reconstructive Surgery

Author: Sara B. Cichowski, Jaime B. Long, Sarah Hamilton Boyles, Taylor J. Brueseke, Brian J. Linder, Krista M. L. Reagan, and Marcella G. Willis-Gray
Subjects: Reconstructive surgery, medicine.medical_specialty, business.industry, Urology, Obstetrics and Gynecology, Perioperative, Opioid prescribing, Opioid, Emergency medicine, Perioperative care, medicine, Hospital discharge, Morphine, Surgery, Medical prescription, business, medicine.drug
Abstract: OBJECTIVE This study aimed to provide female pelvic medicine and reconstructive surgery (FPMRS) providers with evidence-based guidance on opioid prescribing following surgery. METHODS A literature search of English language publications between January 1, 2000, and March 31, 2021, was conducted. Search terms identified reports on opioid prescribing, perioperative opioid use, and postoperative pain after FPMRS procedures. Publications were screened, those meeting inclusion criteria were reviewed, and data were abstracted. Data regarding the primary objective included the oral morphine milligram equivalents of opioid prescribed and used after discharge. Information meeting criteria for the secondary objectives was collected, and qualitative data synthesis was performed to generate evidence-based practice guidelines for prescription of opioids after FPMRS procedures. RESULTS A total of 6,028 unique abstracts were identified, 452 were screened, and 198 full-text articles were assessed for eligibility. Fifteen articles informed the primary outcome, and 32 informed secondary outcomes. CONCLUSIONS For opioid-naive patients undergoing pelvic reconstructive surgery, we strongly recommend surgeons to provide no more than 15 tablets of opioids (roughly 112.5 morphine milligram equivalents) on hospital discharge. In cases where patients use no or little opioids in the hospital, patients may be safely discharged without postoperative opioids. Second, patient and surgical factors that may have an impact on opioid use should be assessed before surgery. Third, enhanced recovery pathways should be used to improve perioperative care, optimize pain control, and minimize opioid use. Fourth, systemic issues that lead to opioid overprescribing should be addressed. Female pelvic medicine and reconstructive surgery surgeons must aim to balance adequate postoperative pain control with individual and societal risks associated with excess opioid prescribing.
Published: 2021
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15. Correlation of cytology to histology in a case of canine granulomatous colitis in a Boxer dog

Author: M Katherine Tolbert, Jennifer A. Neel, Jonathan Nagle, Cory S. Sims, Katie Anderson, and Keith E. Linder
Subjects: medicine.medical_specialty, Pathology, General Veterinary, business.industry, Histology, medicine.disease, Ulcerative colitis, Hematochezia, Cytology, Enrofloxacin, medicine, Granulomatous colitis, Histopathology, medicine.symptom, Colitis, business, medicine.drug
Abstract: A 2-year-old castrated male mixed breed dog presented to the North Carolina State Veterinary Teaching Hospital for chronic diarrhea with hematochezia and weight loss. Cytology performed on a rectal scraping revealed macrophages containing magenta, light pink, and variably blue granular inclusions, and phagocytosed material concerning for infectious organisms. Histopathology was consistent with granulomatous colitis and identified intra-histiocytic bacterial organisms, confirmed by fluorescent in situ hybridization (FISH)-tissue culture-confirmed Escherichia coli. Based on these findings, a diagnosis of granulomatous colitis was made. The patient was successfully treated with oral enrofloxacin, and near-complete remission of signs was achieved within 6 weeks. This report describes a case of granulomatous colitis in a mixed breed dog, and is the first published description of the cytologic features of this uncommon disease, offering a valuable cytologic-histologic correlation. In this case, the cytology was helpful in identifying features consistent with granulomatous colitis and prioritizing the differential diagnoses and diagnostic plan.
Published: 2021
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16. Impact of cardiopulmonary bypass and surgical complexity on plasma soluble urokinase-type plasminogen activator receptor levels after cardiac surgery

Author: Niklas Sterner, Jane Fisher, Alain Dardashti, Adam Linder, Louise Thelaus, Johan Nilsson, and Igor Zindovic
Subjects: medicine.medical_specialty, Clinical Biochemistry, Inflammation, Gastroenterology, Receptors, Urokinase Plasminogen Activator, law.invention, law, Internal medicine, Cardiopulmonary bypass, Humans, Medicine, Cardiac Surgical Procedures, Receptor, Urokinase, Cardiopulmonary Bypass, business.industry, Urokinase Plasminogen Activator, General Medicine, Prognosis, Cardiac surgery, SuPAR, medicine.symptom, business, Plasminogen activator, Biomarkers, medicine.drug
Abstract: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of inflammation with prognostic value for elevated risk of morbidity and mortality. It has not yet been shown how the inflammatory process induced by cardiac surgery affects suPAR concentrations postoperatively.In a prospective observational study, plasma suPAR levels were measured in 30 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), pre-, peri, post-operatively, and 3-5 days after surgery. Fifteen patients underwent coronary artery bypass grafting (CABG) and 15 underwent complex procedures with longer CPB duration. Concentrations of suPAR at each time point were compared to the preoperative levels and compared between the two groups.In both groups, plasma suPAR concentrations were significantly higher on the first postoperative day (3.27 (interquartile range (IQR) 2.75-3.86) µg/L compared to baseline (2.62 (1.98-3.86)) µg/L,After a transient rise on the first postoperative day, the suPAR levels returned to the preoperative levels by the third postoperative day. There was no significant difference in suPAR levels between the routine CABG and complex group with longer CPB time.
Published: 2021
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17. Use of intravenous iron and risk of anaphylaxis

Author: Nicholas Moore, Patrick Blin, Jochen Dress, Antje Timmer, Jacques Benichou, Jonas Reinold, Ron M.C. Herings, Edeltraut Garbe, Ingvild Odsbu, Susana Perez-Gutthann, Nuria Saigi-Morgui, Gunnar Toft, Vera Ehrenstein, Cécile Droz-Perroteau, Andreas J. Bircher, D. S. Rampton, Michael Forstner, Carla Franzoni, Elisabeth Smits, Joan Fortuny, Régis Lassalle, Katherine Rascher, Gero von Gersdorff, Mathias Schaller, Kenneth J. Rothman, Jetty A. Overbeek, Tania Schink, Marie Linder, Bianca Kollhorst, Lawrence Rasouliyan, Lia Gutierrez, RTI Health Solutions, Research Triangle Institute International (RTI International), University of Cologne, CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Karolinska Institutet [Stockholm], PHARMO Institute for Drug Outcomes Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Aarhus University [Aarhus], Carl Von Ossietzky Universität Oldenburg, Vrije Universiteit Amsterdam [Amsterdam] (VU), CHU Rouen, Normandie Université (NU), Université de Rouen Normandie (UNIROUEN), University Hospital Basel [Basel], Università della Svizzera italiana = University of Italian Switzerland (USI), Royal Free Hospital [London, UK], General practice, and Epidemiology and Data Science
Subjects: medicine.medical_specialty, severe hypersensitivity reactions, Epidemiology, Iron, Pharmacy, 01 natural sciences, Cohort Studies, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, anaphylaxis, cohort study, Humans, Pharmacology (medical), Cumulative incidence, 030212 general & internal medicine, 0101 mathematics, IV iron, Anaphylaxis, Dextran, business.industry, Original Articles, medicine.disease, Severe hypersensitivity reactions, Confidence interval, 3. Good health, Penicillin, Europe, dextran, Ambulatory, Observational study, Administration, Intravenous, Original Article, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Cohort study, multidatabase, Multidatabase, medicine.drug
Abstract: International audience; PURPOSE: This post-authorisation safety study estimated the risk of anaphylaxis in patients receiving intravenous (IV) iron in Europe, with interest in iron dextran and iron non-dextrans. Studies conducted in the United States have reported risk of anaphylaxis to IV iron ranging from 2.0 to 6.8 per 10 000 first treatments. METHODS: Cohort study of IV iron new users, captured mostly through pharmacy ambulatory dispensing, from populations covered by health and administrative data sources in five European countries from 1999 to 2017. Anaphylaxis events were identified through an algorithm that used parenteral penicillin as a positive control. RESULTS: A total of 304 210 patients with a first IV iron treatment (6367 iron dextran), among whom 13–16 anaphylaxis cases were identified and reported as a range to comply with data protection regulations. The pooled unadjusted incidence proportion (IP) ranged from 0.4 (95% confidence interval [CI], 0.2–0.9) to 0.5 (95% CI, 0.3–1.0) per 10 000 first treatments. No events were identified at first dextran treatments. There were 231 294 first penicillin treatments with 30 potential cases of anaphylaxis (IP = 1.2; 95% CI, 0.8–1.7 per 10 000 treatments). CONCLUSION: We found an IP of anaphylaxis from 0.4 to 0.5 per 10 000 first IV iron treatments. The study captured only a fraction of IV iron treatments administered in hospitals, where most first treatments are likely to happen. Due to this limitation, the study could not exclude a differential risk of anaphylaxis between iron dextran and iron non-dextrans. The IP of anaphylaxis in users of penicillin was consistent with incidences reported in the literature.
Published: 2021
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18. Neptune: an environment for the delivery of genomic medicine

Author: Venner Eric, Victoria Yi, David Murdock, Sara E. Kalla, Tsung-Jung Wu, Aniko Sabo, Shoudong Li, Qingchang Meng, Xia Tian, Mullai Murugan, Michelle Cohen, Christie Kovar, Wei-Qi Wei, Wendy K. Chung, Chunhua Weng, Georgia L. Wiesner, Gail P. Jarvik, Donna Muzny, Richard A. Gibbs, Debra Abrams, Samuel E. Adunyah, Ladia Albertson-Junkans, Berta Almoguera, Darren C. Ames, Paul Appelbaum, Samuel Aronson, Sharon Aufox, Lawrence J. Babb, Adithya Balasubramanian, Hana Bangash, Melissa Basford, Lisa Bastarache, Samantha Baxter, Meckenzie Behr, Barbara Benoit, Elizabeth Bhoj, Suzette J. Bielinski, Sarah T. Bland, Carrie Blout, Kenneth Borthwick, Erwin P. Bottinger, Mark Bowser, Harrison Brand, Murray Brilliant, Wendy Brodeur, Pedro Caraballo, David Carrell, Andrew Carroll, Lisa Castillo, Victor Castro, Gauthami Chandanavelli, Theodore Chiang, Rex L. Chisholm, Kurt D. Christensen, Wendy Chung, Christopher G. Chute, Brittany City, Beth L. Cobb, John J. Connolly, Paul Crane, Katherine Crew, David R. Crosslin, Jyoti Dayal, Mariza De Andrade, Jessica De la Cruz, Josh C. Denny, Shawn Denson, Tim DeSmet, Ozan Dikilitas, Michael J. Dinsmore, Sheila Dodge, Phil Dunlea, Todd L. Edwards, Christine M. Eng, David Fasel, Alex Fedotov, Qiping Feng, Mark Fleharty, Andrea Foster, Robert Freimuth, Christopher Friedrich, Stephanie M. Fullerton, Birgit Funke, Stacey Gabriel, Vivian Gainer, Ali Gharavi, Andrew M. Glazer, Joseph T. Glessner, Jessica Goehringer, Adam S. Gordon, Chet Graham, Robert C. Green, Justin H. Gundelach, Heather S. Hain, Hakon Hakonarson, Maegan V. Harden, John Harley, Margaret Harr, Andrea Hartzler, M. Geoffrey Hayes, Scott Hebbring, Nora Henrikson, Andrew Hershey, Christin Hoell, Ingrid Holm, Kayla M. Howell, George Hripcsak, Jianhong Hu, Elizabeth Duffy Hynes, Joy C. Jayaseelan, Yunyun Jiang, Yoonjung Yoonie Joo, Sheethal Jose, Navya Shilpa Josyula, Anne E. Justice, Divya Kalra, Elizabeth W. Karlson, Brendan J. Keating, Melissa A. Kelly, Eimear E. Kenny, Dustin Key, Krzysztof Kiryluk, Terrie Kitchner, Barbara Klanderman, Eric Klee, David C. Kochan, Viktoriya Korchina, Leah Kottyan, Emily Kudalkar, Alanna Kulchak Rahm, Iftikhar J. Kullo, Philip Lammers, Eric B. Larson, Matthew S. Lebo, Magalie Leduc, Ming Ta (Michael) Lee, Niall J. Lennon, Kathleen A. Leppig, Nancy D. Leslie, Rongling Li, Wayne H. Liang, Chiao-Feng Lin, Jodell E. Linder, Noralane M. Lindor, Todd Lingren, James G. Linneman, Cong Liu, Wen Liu, Xiuping Liu, John Lynch, Hayley Lyon, Alyssa Macbeth, Harshad Mahadeshwar, Lisa Mahanta, Bradley Malin, Teri Manolio, Maddalena Marasa, Keith Marsolo, Michelle L. McGowan, Elizabeth McNally, Jim Meldrim, Frank Mentch, Hila Milo Rasouly, Jonathan Mosley, Shubhabrata Mukherjee, Thomas E. Mullen, Jesse Muniz, David R. Murdock, Shawn Murphy, Melanie F. Myers, Bahram Namjou, Yizhao Ni, Robert C. Onofrio, Aniwaa Owusu Obeng, Thomas N. Person, Josh F. Peterson, Lynn Petukhova, Cassandra J. Pisieczko, Siddharth Pratap, Cynthia A. Prows, Megan J. Puckelwartz, Ritika Raj, James D. Ralston, Arvind Ramaprasan, Andrea Ramirez, Luke Rasmussen, Laura Rasmussen-Torvik, Soumya Raychaudhuri, Heidi L. Rehm, Marylyn D. Ritchie, Catherine Rives, Beenish Riza, Dan M. Roden, Elisabeth A. Rosenthal, Avni Santani, Schaid Dan, Steven Scherer, Stuart Scott, Aaron Scrol, Soumitra Sengupta, Ning Shang, Himanshu Sharma, Richard R. Sharp, Rajbir Singh, Patrick M.A. Sleiman, Kara Slowik, Joshua C. Smith, Maureen E. Smith, Duane T. Smoot, Jordan W. Smoller, Sunghwan Sohn, Ian B. Stanaway, Justin Starren, Mary Stroud, Jessica Su, Casey Overby Taylor, Kasia Tolwinski, Sara L. Van Driest, Sean M. Vargas, Matthew Varugheese, David Veenstra, Eric Venner, Miguel Verbitsky, Gina Vicente, Michael Wagner, Kimberly Walker, Theresa Walunas, Liwen Wang, Qiaoyan Wang, Scott T. Weiss, Quinn S. Wells, Peter S. White, Ken L. Wiley, Janet L. Williams, Marc S. Williams, Michael W. Wilson, Leora Witkowski, Laura Allison Woods, Betty Woolf, Julia Wynn, Yaping Yang, Ge Zhang, Lan Zhang, and Hana Zouk
Subjects: Computer science, business.industry, Process (engineering), MEDLINE, High-Throughput Nucleotide Sequencing, Genomics, Data science, Article, Personalization, Variety (cybernetics), Workflow, Neptune, Pharmacogenomics, Health care, Electronic Health Records, Humans, business, Software, Genetics (clinical)
Abstract: Genomic medicine holds great promise for improving health care, but integrating searchable and actionable genetic data into electronic health records (EHRs) remains a challenge. Here we describe Neptune, a system for managing the interaction between a clinical laboratory and an EHR system during the clinical reporting process. We developed Neptune and applied it to two clinical sequencing projects that required report customization, variant reanalysis, and EHR integration. Neptune has been applied for the generation and delivery of over 15,000 clinical genomic reports. This work spans two clinical tests based on targeted gene panels that contain 68 and 153 genes respectively. These projects demanded customizable clinical reports that contained a variety of genetic data types including single-nucleotide variants (SNVs), copy-number variants (CNVs), pharmacogenomics, and polygenic risk scores. Two variant reanalysis activities were also supported, highlighting this important workflow. Methods are needed for delivering structured genetic data to EHRs. This need extends beyond developing data formats to providing infrastructure that manages the reporting process itself. Neptune was successfully applied on two high-throughput clinical sequencing projects to build and deliver clinical reports to EHR systems. The software is open source and available at https://gitlab.com/bcm-hgsc/neptune .
Published: 2021
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19. Electroconvulsive Therapy in the Epicenter of COVID-19

Author: Kristy Loewenstein, Georgios Petrides, Howard Linder, Liezl Mangubat, Mark Glick, Sohag Sanghani, Sean Allan, Ignat Bashkirov, and Jason Andrus
Subjects: Adult, Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Infectious Disease Transmission, Patient-to-Professional, Adolescent, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Neuroscience (miscellaneous), Young Adult, Electroconvulsive therapy, Humans, Medicine, Electroconvulsive Therapy, Pandemics, Aged, Aged, 80 and over, business.industry, Patient Selection, COVID-19, Middle Aged, Psychiatry and Mental health, Epicenter, Emergency medicine, Female, New York City, business
Published: 2021
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20. Treatment patterns in women seeking care for endometriosis at an endometriosis center

Author: Katharine E. Linder, Adela G. Cope, Chia-Sui Weng, Kristin C. Mara, Zaraq Khan, and Tatnai L. Burnett
Subjects: medicine.medical_specialty, business.industry, General surgery, Pelvic pain, medicine, Endometriosis, Surgical excision, medicine.symptom, business, medicine.disease, Gynecologic surgical procedures
Abstract: Objective: To determine the clinical characteristics and prior medical and surgical treatments in women undergoing surgical excision of endometriosis for pelvic pain at a single institution. Methods: In this retrospective cohort study we identified 140 women with pathology-proven endometriosis who completed a preoperative standardized pain form and underwent surgery at an endometriosis center. Women were stratified into three groups for analysis: no prior surgery, 1 prior surgery, and 2+ prior surgeries. Results: The most common treatments used prior to seeking care were hormonal contraceptives (51.6%) and surgery (46.1%). More than half of women were diagnosed with pelvic floor dysfunction at time of presentation or prior to consultation. There was a significant relationship between an increasing number of surgeries (none vs 1 vs 2+) and gonadotropin-releasing hormone (GnRH) agonist use (19.0% vs 27.5% vs 56.0%, p = 0.003). Though not significant, a trend was noted between increasing surgeries and opioid use (20.6% vs 30.0% vs 40.0%, p = 0.17). There was a statistically significant relationship between multiple surgeries and illicit drug use ( p Conclusion: Patients with pelvic pain and endometriosis who have undergone multiple surgeries are more likely to have used GnRH agonists and report illicit drug use prior to presenting to specialized care.
Published: 2021
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21. The Dynamics of Heparin-Binding Protein in Cardiothoracic Surgery—A Pilot Study

Author: Niklas Sterner, Igor Zindovic, Jane Fisher, Johan Nilsson, Carolin Ketteler, Špela Lemež, Alain Dardashti, Louise Thelaus, and Adam Linder
Subjects: medicine.medical_specialty, Pilot Projects, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, law, Cardiopulmonary bypass, medicine, Humans, Prospective Studies, Cardiopulmonary Bypass, Heparin, business.industry, Organ dysfunction, Blood Proteins, Perioperative, Intensive care unit, Cardiac surgery, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Cardiothoracic surgery, Anesthesia, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Antimicrobial Cationic Peptides, Artery, medicine.drug
Abstract: Objectives To explore the preoperative, intraoperative, and postoperative dynamics of heparin-binding protein (HBP) in cardiothoracic surgery. Design This was a prospective, observational study. Setting The study was conducted at a single university hospital. Participants Thirty patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were included, 15 of whom underwent coronary artery bypass grafting surgery and 15 of whom underwent complex procedures. Ten patients undergoing lung surgery also were included as a conventional surgery reference group. Interventions No interventions were performed. Measurements and Main Results HBP was measured at nine different perioperative times. HBP levels increased immediately after heparin administration, further increased during CPB, but decreased rapidly after protamine administration. At arrival to the intensive care unit, median HBP levels were 24.8 (15.6-38.1) ng/mL for coronary artery bypass grafting patients and 51.2 (34.0-117.7) ng/mL for complex surgery patients (p = 0.011). One day after surgery, HBP levels in all three groups were below the proposed cutoff of 30 ng/mL, which previously was found to predict development of organ dysfunction in patients with infection. Conclusions HBP levels are elevated by the administration of heparin and the use of CPB but reduced by protamine administration. At postoperative day one, HBP levels were less than the threshold for organ dysfunction in patients with infection. The usefulness of HBP for predicting postoperative infections in cardiothoracic surgery should be investigated in future studies.
Published: 2021
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22. Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

Author: Akowuah, Enoch, Benson, Ruth A., Caruana, Edward J., Chetty, Govind, Edwards, John, Forlani, Stefano, Gradinariu, George, Murphy, Gavin J., Oo, Aung Ye, Patel, Akshay J., Ridley, Brenda, Rogers, Luke J., Sanders, Julie, Tyson, Nathan, Vaja, Ricky, Siaw-Acheampong, Kwabena, Argus, Leah, Chaudhry, Daoud, Dawson, Brett E., Glasbey, James C., Gujjuri, Rohan R., Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Keatley, James M., Lawday, Samuel, Li, Elizabeth, Mann, Harvinder, Marson, Ella J., Mclean, Kenneth A., Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Nepogodiev, Dmitri, Dajti, Irida, Gjata, Arben, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohanes, Hailu, Dr. Samuel, Tamiru, Hailu, Kauppila, Joonas, Laukkarinen, Johanna, Arnaud, Alexis, Albertsmeiers, Markus, Lederhuber, Hans, Loffler, Markus, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tamas, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Faris, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moises, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andreas, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelos, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Dennis, Simoes, Joana F. F., Dajti, I., Valenzuela, J. I., Boccalatte, L. A., Gemelli, N. A., Smith, D. E., Dudi-Venkata, N. N., Kroon, H. M., Sammour, T., Roberts, M., Mitchell, D., Lah, K., Pearce, A., Morton, A., Dawson, A. C., Drane, A., Sharpin, C., Nataraja, R. M., Pacilli, M., Cox, D. R. A., Muralidharan, V., Riddiough, G. E., Clarke, E. M., Jamel, W., Qin, K. R., Pockney, P., Cope, D., Egoroff, N., Lott, N., Putnis, S., De Robles, S., Ang, Z., Mitteregger, M., Uranitsch, S., Stiegler, M., Seitinger, G., Aigner, F., Lumenta, D. B., Nischwitz, S. P., Richtig, E., Pau, M., Srekl-Filzmaier, P., Eibinger, N., Michelitsch, B., Fediuk, M., Papinutti, A., Seidel, G., Kahn, J., Cohnert, T. U., Messner, F., Öfner, D., Presl, J., Varga, M., Weitzendorfer, M., Emmanuel, K., Binder, A. D., Zimmermann, M., Holawe, S., Nkenke, E., Grimm, C., Kranawetter, M., Rahman Mitul, A., Islam, N., Karim, S., Komen, N., Ang, E., De Praetere, H., Tollens, T., Schols, G., Smets, C., Haenen, L., Quintens, J., Van Belle, K., Van Ramshorst, G. H., Pattyn, P., Desender, L., Martens, T., Van de putte, D., Lerut, P., Grimonprez, A., Janssen, M., De Smul, G., Wallaert, P., Van den Eynde, J., Oosterlinck, W., Van den Eynde, R., Sermon, A., Boeckxstaens, A., Cordonnier, A., De Coster, J., Jaekers, J., Politis, C., Miserez, M., Duchateau, N., De Gheldere, C., Flamey, N., Christiano, A., Guidi, B., Minussi, A. L., Castro, S., Okoba, W., Maldonado, F. H. R., Oliveira, P., Baldasso, T., Santos, L., Gomes, G. M. A., Buarque, I. L., Pol-Fachin, L., Bezerra, T. S., Barros, A. V., da Silva, A. M. R., Leite, A. L. S., Silvestre, D. W. A., Ferro, C. C., Araujo, M. S., Lopes, L. M., Damasceno, P. D., Araujo, D. H. S., Laporte, G., Salem, M. C., Guimaraes-Filho, M. A. C., Nacif, L., Flumignan, R. L. G., Nakano, L. C. U., Kuramoto, D. A. B., Aidar, A. L. S., Pereda, M. R., Correia, R. M., Santos, B. C., Carvalho, A. A., Amorim, J. E., Guedes Neto, H. J., Areias, L. L., Sousa, A. F., Flumignan, C. D. Q., Lustre, W. G., Moreno, D. H., Barros, N., Baptista-Silva, J. C. C., Matos, L. L., Kowaski, L. P., Kulcsar, M. A. V., Nunes, K. S., Teixeira, M. F., Nunes, R. L., Ijichi, T. R., Kim, N. J., Marreiro, A., Muller, B., Barakat Awada, J., Baiocchi, G., Kowalski, L. P., Vartanian, J. G., Makdissi, F. B., Aguiar, S., Marques, N., Carvalho, G. B., Marques, T. M. D. M., Abdallah, E. A., Zurstrassen, C. E., Gross, J. L., Zequi, S. C., Gonçalves, B. T., Santos, S. S., Duprat, J. P., Coimbra, F. J. F., Cicco, R., Takeda, F., Cecconello, I., Ribeiro, U., Gatti, A., Oliva, R., Nardi, C., Slavchev, M., Atanasov, B., Belev, N., Dell, A., Bigam, D., Dajani, K., Al Riyami, S., Martin, J., Cheng, D., Yang, H., Fayad, A., Carrier, F. M., Amzallag, E., Desroches, J., Ruel, M., Caminsky, N. G., Boutros, M., Moon, J., Wong, E. G., Vanounou, T., Pelletier, J., Wong, S., Girsowicz, E., Bayne, J., Obrand, D., Gill, H., Steinmetz, O., MacKenzie, K., Lukaszewski, M., Jamjoum, G., Richebé, P., Verdonck, O., Discepola, S., Godin, N., Idrissi, M., Briatico, D., Sharma, S., Talwar, G., Bailey, K., Lecluyse, V., Côté, G., Demyttenaere, S., Garfinkle, R., Kouyoumdjian, A., Dumitra, S., Khwaja, K., Luo, L., Berry, G., Liberman, A. S., Schmid, S., Spicer, J., Al Farsi, M., Abou-Khalil, J., Couture, E., Mohammadi, S., Tremblay, H., Gagné, N., Bergeron, A., Turgeon, Af, Costerousse, O., Bellemare, D., Babin, C., Blier, C., Wood, M. L., Persad, A., Groot, G., Pham, H., D'Aragon, F., Carbonneau, E., Bouchard, M., Masse, M., Pesant, F., Héroux, J., Karanicolas, P., Hallet, J., Nadler, A., Nathens, A., Ko, M., Brar, A., Mayson, K., Kidane, B., Srinathan, S., Escudero, M. I., Reyes, J. T., Modolo, M. M., Ramirez Nieto, P., Sepulveda, R., Bolbarán, A., Molero, A., Ruiz, I., Reyes, G. P., Salas, R., Suazo, C., Muñoz, R., Grasset, E., Inzunza, M., Besser, N., Irarrázaval, M. J., Jarry, C., Bellolio, F., Romero Manqui, C. A., Ruiz Esquide, M., Fuentes, T., Campos, J., Perez Rivera, C. J., Cabrera, P. A., Pinilla, R. E., Guevara, O., Jimenez Ramirez, L. J., Velasquez Cuasquen, B. G., Herrera Mora, D. R., Bonilla, A., Diaz, S., Manrique, E., Facundo, H., Velez Bernal, J. L., Ángel, J., García, M., Guzmán, L., Lehmann, C., Cervera, S., Trujillo Sanchez, L. M., Guevara, R., Valbuena, D., Suarez, L., Jimenez, G., Velandia, A., Vargas, J., Espinosa, J., Rey, S., Mendoza Quevedo, Jairo, Calvache, J. A., Orozco-Chamorro, C. M., Sánchez-Gómez, T. A., Rojas-Tejada, D. A., Mihanovic, J., Bakmaz, B., Rakvin, I., Sulen, N., Andabaka, T., Luksic, I., Mamic, M., Martinek, L., Skrovina, M., Žatecký, J., Peteja, M., Kristensen, H. Ø., Mekhael, M., Christensen, P., Westh, L., Smith, H., Haugstvedt, A. F., Jönsson, M. L., Crespo, A., Batista, S., Rodriguez-Abreu, J., Tactuk, N., Diaz-Delgado, P. J., Rivas, R., Sarmiento-Bobadilla, J. A., Ashoush, F., Samir Abdelaal, A., Qatora, M. S., Elsayed Hewalla, M. E., Metwalli, M., Atta, R., Abdelmajeed, A., Abosamak, N. E., Sabry, A., Shehata, S., Sallam, I., Amira, G., Sherief, M., Sherif, A., Salem, H., Hamdy, R., Aboulkassem, H., Ghaly, G., Sherif, G., Morsi, A., Abdelrahman, A., Omnia, Ahmed, Tawheed, A., El Kassas, M., Omar, W., Abdelsamed, A., Seleim, A., Azzam, A. Y., ElFiky, M., Nabil, A., Ibraheem, M., ELDeeb, M., Fawzy, M., Hamed, H., Emile, S., Elfallal, A., Elfeki, H., Shalaby, M., Sakr, A., Alrahawy, M., Atif, H., Soltan, H., Sayed, A. K., Salah, A., Atiya, A., Wassim, K., Abbas, A. M., Abd Elazeem, H. A. S., Abd-Elkariem, A. Y., Abd-Elkarem, M. M., Alaa, S., Ali, A. K., Ashraf, M., Ayman, A., Azizeldine, M. G., Elkhayat, H., Emad Mashhour, A., Gaber, M., Hamza, H. M., Hawal, I., Hetta, H. F., Elghazaly, S. M., Mohammed, M. M., Monib, F. A., Nageh, M. A., Saad, A., Saad, M. M., Shahine, M., Yousof, E. A., Youssef, A., Esmail, E., Khalaf, M., Eldaly, A., Ghoneim, A., Hawila, A., Badr, H., Elhalaby, I., Abdel-bari, M., Elbahnasawy, M., Hamada, M. K., Morsy, M. S., Hammad, M., Essa, M., Fayed, M. T., Elzoghby, M., Rady, M., Hamad, O., Salman, S., Sarsik, S., Abd-elsalam, S., Gamal Badr, S., El-Masry, Y., Moahmmed, M. M. H., Hailu, S., Wolde, A., Mengesha, M., Nida, S., Workneh, M., Y Ahmed, M., Fisseha, T., Kassa, D., Zeleke, H., Admasu, A., Laeke, T., Tirsit, A., Gessesse, M., Addissie, A., Bekele, D., Kauppila, J. H., Sarjanoja, E., Testelin, S., Dakpé, S., Devauchelle, B., Bettoni, J., Lavagen, N., Schmitt, F., Lemée, J. M., Boucher, S., Breheret, R., Kün-Darbois, J. D., Kahn, A., Gueutier, A., Bigot, P., Borraccino, B., Lakkis, Z., Doussot, A., Heyd, B., Manfredelli, S., Mathieu, P., Paquette, B., Turco, C., Barrabe, A., Louvrier, A., Moszkowicz, D., Giovinazzo, D., Bretagnol, F., Police, A., Charre, L., Volpin, E., Braham, H., El Arbi, N., Villefranque, V., Bendjemar, L., Girard, E., Abba, J., Trilling, B., Chebaro, A., Lecolle, K., Truant, S., El Amrani, M., Zerbib, P., Pruvot, F. R., Mathieu, D., Surmei, E., Mattei, L., Marin, H., Christou, N., Ballouhey, Q., Ferrero, P., Coste Mazeau, P., Tricard, J., Barrat, B., Taibi, A., Usseglio, J., Laloze, J., Salle, H., Fourcade, L., Duchalais, E., Regenet, N., Rigaud, J., Waast, D., Denis, W., Malard, O., Buffenoir, K., Espitalier, F., Ferron, C., Varenne, Y., Crenn, V., De Vergie, S., Cristini, J., Samarut, E., Tzedakis, S., Bouche, P. A., Gaujoux, S., Kantor, E., Gossot, D., Seguin-Givelet, A., Fuks, D., Grigoroiu, M., Sanchez Salas, R., Cathelineau, X., Macek, P., Barbé, Y., Rozet, F., Barret, E., Mombet, A., Cathala, N., Brian, E., Zadegan, F., Conso, C., Blanc, T., Broch, A., Sarnacki, S., Ali, L., Bonnard, A., Peycelon, M., Hervieux, E., Clermidi, P., Maisonneuve, E., Aubry, E., Thomin, A., Langlais, T., Passot, G., Glehen, O., Cotte, E., Lifante, J. C., De Simone, B., Chouillard, E., Arnaud, A. P., Violas, P., Bergeat, D., Merdrignac, A., Scalabre, A., Perotto, L. O., Le Roy, B., Haddad, E., Vermersch, S., Ezanno, A. C., Barbier, O., Vigouroux, F., Malgras, B., Aime, A., Seeliger, B., Mutter, D., Philouze, G., Pessaux, P., Germain, A., Chanty, H., Ayav, A., Kassir, R., Von theobald, P., Sauvat, F., O'Connor, J., Mayombo Idiata, M., O'Connor, Z., Tchoba, S., Modabber, A., Winnand, P., Hölzle, F., Sommer, B., Shiban, E., Wolf, S., Anthuber, M., Sommer, F., Kaemmerer, D., Schreiber, T., Kamphues, C., Lauscher, J. C., Schineis, C., Loch, F. N., Beyer, K., Nasser, S., Sehouli, J., Höhn, P., Braumann, C., Reinkemeier, F., Uhl, W., Weitz, J., Bork, U., Welsch, T., Praetorius, C., Korn, S., Distler, M., Fluegen, G., Knoefel, W. T., Vay, C., Golcher, H., Grützmann, R., Binder, J., Meister, P., Gallinat, A., Paul, A., Schnitzbauer, A. A., Thoenissen, P., El Youzouri, H., Schreckenbach, T., Nguyen, T. A., Eberbach, H., Bayer, J., Erdle, B., Sandkamp, R., Nitschke, C., Izbicki, J., Uzunoglu, F. G., Koenig, D., Gosau, M., Böttcher, A., Heuer, A., Klatte, T. O., Priemel, M., Betz, C. S., Burg, S., Möckelmann, N., Busch, C. J., Bewarder, J., Zeller, N., Smeets, R., Thole, S., Vollkommer, T., Speth, U., Stangenberg, M., Hakami, I., Boeker, C., Mall, J., Schardey, H. M., von Ahnen, T., von Ahnen, M., Brunner, U., Tapking, C., Kneser, U., Hirche, C., Jung, M., Kowalewski, K. F., Kienle, P., Reissfelder, C., Seyfried, S., Herrle, F., Hardt, J., Galata, C., Birgin, E., Rahbari, N., Vassos, N., Stoleriu, M. G., Hatz, R., Albertsmeier, M., Börner, N., Lampert, C., Werner, J., Kuehlmann, B., Prantl, L., Brunner, S. M., Schlitt, H. J., Brennfleck, F., Pfister, K., Oikonomou, K., Reinhard, T., Nowak, K., Ronellenfitsch, U., Kleeff, J., Delank, K. S., Michalski, C. W., Szabo, G., Widyaningsih, R., Stavrou, G. A., Bschorer, R., Mielke, J., Peschel, T., Königsrainer, A., Quante, M., Löffler, M. W., Yurttas, C., Doerner, J., Seiberth, R., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Syllaios, A., Baili, E., Schizas, D., Liakakos, T., Charalabopoulos, A., Zografos, C., Spartalis, E., Manatakis, D. K., Tasis, N., Antonopoulou, M. I., Xenaki, S., Xynos, E., Chrysos, E., Athanasakis, E., Tsiaousis, J., Lostoridis, E., Tourountzi, P., Tzovaras, G., Tepetes, K., Zacharoulis, D., Baloyiannis, I., Perivoliotis, K., Hajiioannou, J., Korais, C., Gkrinia, E., Skoulakis, C. E., Saratziotis, A., Koukoura, O., Symeonidis, D., Diamantis, A., Tsoulfas, G., Christou, C. D., Tooulias, A., Papadopoulos, V., Anthoulakis, C., Grimbizis, G., Zouzoulas, D., Tsolakidis, D., Tatsis, D., Christidis, P., Loutzidou, L., Ioannidis, O., Astreidis, I., Antoniou, A., Antoniadis, K., Vachtsevanos, K., Paraskevopoulos, K., Kalaitsidou, I., Alexoudi, V., Stavroglou, A., Mantevas, A., Michailidou, D., Grivas, T., Deligiannidis, D., Politis, S., Barrios Duarte, A., Portilla, A. L., Lowey, M. J., Recinos, G., Lopez Muralles, I., Siguantay, M. A., Estrada, E. E., Aguilera-Arévalo, M. L., Cojulun, J. M., Echeverría-Dávila, G., Marín, C., Icaza de Marín, G. C., Kok, S. Y., Joeng, H. K. M., Chan, L. L., Lim, D., Novak, Z., Echim, T., Suszták, N., Banky, B., Kembuan, G., Pajan, H., Islam, A. A., Rahim, F., Safari, H., Mozafari, M., Brouki Milan, P., Tizmaghz, A., Rezaei Tavirani, M., Ahmed, A., Hussein, R., Fleming, C., O'Brien, S., Kayyal, M. Y., Daly, A., Killeen, S., Corrigan, M., De Marchi, J., Hill, A., Farrell, T., Davis, N. F., Kearney, D., Nelson, T., Maguire, P. J., Barry, C., Farrell, R., Smith, L. A., Mohan, H. M., Mehigan, B. J., Mccormick, P., Larkin, J. O., Fahey, B. A., Rogers, A., Donlon, N., O'Sullivan, H., Nugent, T., Reynolds, J. V., Donohue, C., Shokuhi, P., Ravi, N., Fitzgerald, C., Lennon, P., Timon, C., Kinsella, J., Smith, J., Boyle, T., Alazawi, D., Connolly, E., Butt, W., Croghan, S. M., Manecksha, R. P., Fearon, N., Winter, D., Heneghan, H., Maguire, D., Gallagher, T., Conlon, K., Kennedy, N., Martin, S., Kennelly, R., Hanly, A., Ng, K. C., Fagan, J., Geary, E., Cullinane, C., Carrington, E., Geraghty, J., McDermott, E., Pritchard, R., McPartland, D., Boland, M., Stafford, A., Geoghegan, J., Elliott, J. A., Ridgway, P. F., Gillis, A. E., Bass, G. A., Neary, P. C., O'Riordan, J. M., Kavanagh, D. O., Reynolds, I. S., K, Conlon, Joyce, D. P., Boyle, E., Egan, B., Whelan, M., Elkady, R., Tierney, S., Connelly, T. M., Earley, H., Umair, M., O'Connell, C., Thomas, A. Z., Rice, D., Madden, A., Bashir, Y., Creavin, B., Cullivan, O., Owens, P., Canas-Martinez, A., Murphy, C., Pickett, L., Murphy, B., Mastrosimone, A., Beddy, D., Arumugasamy, M., Allen, M., Aremu, M., McCarthy, C., O’Connor, C., O'Connor, D. B., Kent, E., Malone, F., Geary, M., McKevitt, K. L., Lowery, A. J., Ryan, É. J., Aherne, T. M., Fowler, A., Hassanin, A., Hogan, A. M., Collins, C. G., Finnegan, L., Carroll, P. A., Kerin, M. J., Walsh, S. R., Nally, D., Peirce, C., Coffey, J. C., Cunningham, R. M., Tormey, S., Hardy, N. P., Neary, P. M., Muallem-Kalmovich, L., Kugler, N., Lavy, R., Zmora, O., Horesh, N., Vergari, R., Mochet, S., Barmasse, R., Usai, A., Morelli, L., Picciariello, A., Papagni, V., Altomare, D. F., Colledan, M., Zambelli, M. F., Tornese, S., Camillo, A., Rausa, E., Bianco, F., Lucianetti, A., Prucher, G. M., Baietti, A. M., Ruggiero, F., Maremonti, P., Neri, F., Ricci, S., Biasini, M., Zarabini, A. G., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Della Gatta, A. N., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pilu, G., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Tonini, V., Sartarelli, L., Cervellera, M., Gori, A., Armatura, G., Scotton, G., Patauner, S., Frena, A., Podda, M., Pisanu, A., Esposito, G., Frongia, F., Abate, E., Laface, L., Casati, M., Schiavo, M., Casiraghi, T., Sammarco, G., Gallo, G., Vescio, G., Fulginiti, S., Scorcia, V., Giannaccare, G., Carnevali, A., Giuffrida, M. C., Marano, A., Palagi, S., Di Maria Grimaldi, S., Testa, V., Peluso, C., Borghi, F., Simonato, A., Puppo, A., D'Agruma, M., Chiarpenello, R., Pellegrino, L., Maione, F., Cianflocca, D., Pruiti Ciarello, V., Giraudo, G., Gelarda, E., Dalmasso, E., Abrate, A., Daniele, A., Ciriello, V., Rosato, F., Garnero, A., Leotta, L., Giacometti, M., Zonta, S., Lomiento, D., Taglietti, L., Dester, S., Compagnoni, B., Viotti, F., Cazzaniga, R., Del Giudice, R., Mazzotti, F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C. V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A. L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M. G., Lippa, L., Gambacciani, C., Santonocito, O. S., Aquila, F., Pieri, F., Ballabio, M., Bisagni, P., Longhi, M., Armao, T., Madonini, M., Gagliano, A., Pizzini, P., Costanzi, A., Confalonieri, M., Monteleone, M., Colletti, G., Frattaruolo, C., Mari, G., Spinelli, A., Mercante, G., Spriano, G., Gaino, F., Ferreli, F., De Virgilio, A., Rossi, V., Carvello, M. M., Di Candido, F., Kurihara, H., Marrano, E., Torzilli, G., Castoro, C., Carrano, F. M., Martinelli, F., Macchi, A., Fiore, M., Pasquali, S., Cioffi, S. P. B., Baia, M., Abatini, C., Sarre, C., Mosca, A., Biasoni, D., Gronchi, A., Citterio, D., Mazzaferro, V., Cadenelli, P., Gennaro, M., Capizzi, V., Guaglio, M., Sorrentino, L., Bogani, G., Sarpietro, G., Giannini, L., Comini, L. V., Rolli, L., Folli, S., Raspagliesi, F., Piazza, C., Cosimelli, M., Salvioni, R., Antonelli, B., Baldari, L., Boni, L., Cassinotti, E., Pignataro, L., Rossi, G., Torretta, S., Beltramini, G. A., Gianni', A., Tagliabue, M., De Berardinis, R., Pietrobon, G., Chu, F., Cenciarelli, S., Adamoli, L., Ansarin, M., Fumagalli Romario, U., Mastrilli, F., Mariani, N. M., Nicastro, V., Cellerino, P., Colombo, F., Frontali, A., Bondurri, A., Guerci, C., Maffioli, A., Ferrario, L., Candiani, M., Bonavina, G., Ottolina, J., Valsecchi, L., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Negri, G., Bandiera, A., De Nardi, P., Sileri, P., Carlucci, M., Pelaggi, D., Rosati, R., Vignali, A., Parise, P., Elmore, U., Tamini, N., Nespoli, L. C., Rennis, M., Pitoni, L., Chiappetta, M. F., Vico, E., Fruscio, R., Grassi, T., Sasia, D., Migliore, M., Gattolin, A., Rimonda, R., Travaglio, E., Olearo, E., Tufo, A., Marra, E., Maida, P., Marte, G., Tammaro, P., Incollingo, P., Izzo, F., Belli, A., Patrone, R., Albino, V., Leongito, M., Granata, V., Piccirillo, M., Palaia, R., Francone, E., Gentilli, S., Nikaj, H., Fiorini, A., Norcini, C., Chessa, A., Marino, M. V., Mirabella, A., Vaccarella, G., Musini, L., Ampollini, L., Bergonzani, M., Varazzani, A., Bellanti, L., Domenichini, M., Cabrini, E., Fornasari, A., Freyrie, A., Dejana, D. O., D'Angelo, G., Bertoli, G., Di Lella, F., Bocchialini, G., Falcioni, M., Lanfranco, D., Poli, T., Giuffrida, M., Annicchiarico, A., Perrone, G., Catena, F., Raffaele, A., De Manzoni Garberini, A., Baldini, E., Conti, L., Ribolla, M., Capelli, P., Isolani, S. M., Maniscalco, P., Cauteruccio, M., Ciatti, C., Puma Pagliarello, C., Gattoni, S., Galleano, R., Malerba, M., Ciciliot, M., Farnesi, F., Calabrò, M., Pipitone Federico, N. S., Lunghi, E. G., Muratore, A., Di Franco, G., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Simoncini, T., Gadducci, A., Caretto, M., Giannini, A., Perutelli, A., Domenici, L., Garibaldi, S., Capanna, R., Andreani, L., Furbetta, N., Guadagni, S., Bianchini, M., Gianardi, D., Pinotti, E., Montuori, M., Carissimi, F., Baronio, G., Zizzo, M., Castro Ruiz, C., Annessi, V., Montella, M. T., Falco, G., Mele, S., Ferrari, G., Mastrofilippo, V., Mandato, V. D., Aguzzoli, L., Corbellini, C., Baldi, C., Sampietro, G. M., Palini, G. M., Zanini, N., Garulli, G., Barone, R., Murgese, A., Mungo, S., Grasso, M., Marafante, C., Birolo, S. L., Moggia, E., Caccetta, M., Masciandaro, A., Deirino, A., Garino, M., Perinotti, R., Maiello, F., Gordini, L., Lombardi, C. P., Marzi, F., Marra, A. A., Ratto, C., Di Muro, M., Litta, F., De Simone, V., Cozza, V., Rosa, F., Agnes, A., Parello, A., Alfieri, S., Sganga, G., Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G. B., Cicerchia, P. M., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Sagnotta, A., Marino Cosentino, L., Mancini, S., Lisi, G., Spoletini, D., Bellato, V., Campanelli, M., Sica, G., Siragusa, L., Bonavina, L., Asti, E., Bernardi, D., Lovece, A., Perra, T., Porcu, A., Fancellu, A., Feo, C. F., Scanu, A. M., Tuminello, F., Franceschi, A., Langone, A., Fleres, F., Spolini, A., Bordoni, P., Franzini, M., Clarizia, G., Grechi, A., Longhini, A., Guaitoli, E., Manca, G., Grossi, U., Novello, S., Zanus, G., Romano, M., Rossi, S., Ferrara, F., La Torre, M., Pirozzolo, G., Recordare, A., Paiella, S., Turri, G., Rattizzato, S., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Ruzzenente, A., Poletto, E., Conci, S., Casetti, L., Fontana, M., Salvia, R., Malleo, G., Esposito, A., Landoni, L., De Pastena, M., Bassi, C., Tuveri, M., Nobile, S., Marchegiani, G., Bortolasi, L., Sambugaro, E., Malavolta, M., Moretto, G., Impellizzeri, H., Inama, M., Barugola, G., Ascari, F., Ruffo, G., Granieri, S., Cotsoglou, C., Berselli, M., Desio, M., Marchionini, V., Cocozza, E., Di Saverio, S., Ietto, G., Iovino, D., Carcano, G., Ayasra, F., Qasem, A., Ayasra, Y., Al-Masri, M., Abou Chaar, M. K., Al-Najjar, H., Ghandour, K., Alawneh, F., Abdel Jalil, R., Abdel Al, S., Elayyan, M., Ghanem, R., Lataifeh, I., Alsaraireh, O., Abu Za’nouneh, F. J., Fahmawee, T., Ibrahim, A., Obeidat, K., Lee, K. J., Shin, S. J., Chung, H., Albader, I., Alabbad, J., Albader, M. A. S., Bouhuwaish, A., Taher, A. S., Omar, M. S. M., Abdulwahed, E., Biala, M., Morgom, M., Elhadi, A., Alarabi, A., Msherghi, A., Elhajdawe, F., Alsoufi, A., Salamah, A., Salama, H., Bulugma, M., Almabrouk, H., Venskutonis, D., Dainius, E., Kubiliute, E., Bradulskis, S., Parseliunas, A., Kutkevicius, J., Subocius, A., Cheong, Y. J., Masood, M. S., Ngo, C. W., Saravanan, R., Abdul Maei, N., Hayati, F., Amin Sahid, N., Yanowsky Reyes, G., Orozco Perez, J., Damian, R., Santana Ortiz, R., Colunga Tinajero, C. A., Cordera, F., Gómez-Pedraza, A., Maffuz-Aziz, A., Posada, J. A., De la Rosa Abaroa, M. A., Alvarez, M. R., Arrangoiz, R., Hernández, R., Bozada Gutierrez, K., Trejo-Avila, M., Valenzuela-Salazar, C., Herrera-Esquivel, J., Moreno-Portillo, M., Pinto-Angulo, V. M., Sosa-Duran, E. E., Ziad-Aboharp, H., Jimenez Villanueva, X., Soulé Martínez, C. E., Lupián-Angulo, A. I., Martínez Zarate J, Jacobo, Reyes Rodriguez, E., Montalvo Dominguez, G., Becerra García, F. C., Melchor-Ruan, J., Vilar-Compte, D., Romero-Bañuelos, E., Herrera-Gomez, A., Meneses-Garcia, A., Isla-Ortiz, D., Salcedo-Hernández, R. A., Hernández-Nava, J. M., Morales-Castelan, J. E., Posadas-Trujillo, O. E., Buerba, G. A., Alfaro-Goldaracena, A., Pena Gomez-Portugal, E., Lopez-Pena, G., Hinojosa, C. A., Mercado, M. A., Ramos-De la Medina, A., Martinez, L., Duran, I., Gonzalez, D. S., Martinez, M. J., Nayen Sainz de la Fuente, A., Miguelena, L., Hernández Miguelena, L., Louraoui, S. M., El Azhari, A., Rghioui, M., Khya, E., Ghannam, A., Souadka, A., El Ahmadi, B., Belkhadir, Z. H., Majbar, M. 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A., Cárdenas Ruiz de Castilla, D., Mansilla Doria, P., Li Valencia, M. R., Salazar, A., Sarmiento, A., Díaz, C., Morales, E., Ore, E., Zegarra, H., Siccha, J., Guardia, M., Sandoval, M., Mendiola, G. C., Mimbela, M., Diaz-Ruiz, R., Zeta, L. A., Cordova-Calle, E., Nuñez, H. M., Ortiz-Argomedo, M. R., Caballero-Alvarado, J., Salazar-Tantaleán, A., Espinoza-Llerena, R., Aliaga-Ramos, M., Asodisen, O., Jabagat, E., Tedoy, C. M., Ramos, R. A., Lopez, M. P. J., Violago, K. L. E., Aram, R., Carlos Santos, P., Filarca, R. F., Carlos, A., Santos, P., Filarca, R. L., Domingo, E. J., Khu, K. J. O., Lapitan, M. C., Sacdalan, M. D. P., Kho, M. J. N., Baticulon, R. E., Bravo, S. L. R., Cueto, M. A. C., Ramos, C. L., Fuentes, J. R., Sadian, H., Gumarao, A., Barraquio, A., Cruz, E. M., Gonzales, A. D., Reyes, J. A. S., Salud, J. A., Tancinco, E. G., Rivera, R. D., Lim, J. A., Barcelon, J. C., Chiu, J. A., Carballo, M. 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W., Gudal, A., Alasmari, A., Alqahtani, S., Majrashi, S., Mashat, A., Al Raddadi, R., Alharbi, A., Nasser, Y., Hamayel, H., Alhojaili, A., Aljohani, R., Sogair, O., Alfarhan, O., Alzahrani, A., Alzomaili, B., A Azab, M., Alotaibi, M., Maashi, A., Zowgar, A., Alsakkaf, M., Alnemary, M., Khayat, S., Felmban, S., Almhmadi, A., Alqannas, M., Cortés Guiral, D., Alyami, M., Elawad, A., Alhefdhi, A., Alresaini, F., Kurdi, W., Tulbah, M., Aldakheel, M., Alsahan, N., Koussayer, S., Elsheikh, H., Al-qattan, M., Alshanafey, S., Rafique, A., Mahabbat, N., Saeed, B., Al-Kharashi, E., Alsowaina, K., Arab, N., Aljaber, F., Al Hasan, I., Alghamdi, A., Badahdah, F., Alghuliga, A., Abdulfattah, F., Alanazi, F., Albaqami, F., Alsuhaibani, A., AlFakhri, A., Alqasem, S., Alajaji, N., Nouh, T., Bin Nasser, A., Alowais, J., Alburakan, A., Alamri, O., Albdah, A., Alawi, K., Alshalhoub, M., ElSanhoury, K., Almofarreh, A., Ibrahim, S., Elshafie, H., Osman, I., Guzman, T., Mutair, H., Siddiqui, A., Chowdhury, S., Alghamdi, R., Almutrafi, S., Alfaifi, J., D'Souza, J., Alshitwi, A., Alkreedees, N., Alramadhan, M., Alshehri, M., Alobaysi, S., Alshahrani, A., Alshehri, A., Alrashed, M., Altahan, T., Alsabahi, T., Alhossaini, R., Sbaih, M., Alalawi, Y., Alnwijy, K., Al Ayed, A., Ghedan, S., Alharthi, R., Awad, S., I Sharara, M., Abdelrhman, S., Althobaiti, W., Srbinovic, L., Perovic, M., Mikovic, Z., Nikolic, B., Vasiljevic, M., Pazin, V., Mandic Markovic, V., Dimitrijevic, D., Zecevic, N., Gregoric, P., Micic, D., Loncar, Z., Doklestic, K., Ivancevic, N., Djukic, V., Stojakov, D., Ilic, R., Savic, P., Pijanovic, N., Milanovic, M., Radosavljevic, M., Dejanovic, T., Kostic, M., Paskas, J., Bojic, S., Stevanovic, P., Djuric, M., Kadija, M., Tulic, G., Glisovic Jovanovic, I., Lieske, B., Kayombo, E., Kruger, I., De Kock, M., Malan, A., Ferreira, C., Du Preez, H., Mulder, W., Noel, C., Le Grange, S., Lusawana, O., Kies, C., Steyn, E., Janson, J., Buitendag, J. 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B., Choolani Bhojwani E., Acebes Garcia F., Marcos-Santos P., Bueno Canones A.D., Sanchez Gonzalez J., Toledano M., Bailon M., Pacheco Sanchez D., Paniagua Garcia Senorans M., Sanchez-Santos R., Vazquez Melero A., Garcia D., Diez E., Herrero I., Soeda I.M., Camuera M., Balluerca M., Sanchez-Rubio M., Paunero Vazquez P., Martinez-German A., Gracia-Roche C., Gascon-Ferrer I., Duque-Mallen V., De Miguel-Ardevines M.D.C., Sanchez-Fuentes N., Santero-Ramirez M.S., Matute-Najarro M., Herrero-Lopez M., Cantalejo-Diaz M., Gonzalez-Nicolas-Trebol M.T., Saudi-Moro S., Jariod-Ferrer U.M., Rivas F., Escartin J., Blas Laina J.L., Nogues A., Cros B., Talal El-Abur I., Garcia Egea J., Yanez C., Ravindrakumar S., Rodrigo V.S.D., Arulanantham A., Bandara G.B.K.D., Hamid H.K.S., Ali E.E., Widatalla A.B.H., Bakheit I., Awadelkarim M., Ali karar A.A., Saleh M., Taflin H., Myrelid P., Amorim Braz L., Hagander L., Hambraeus M., Omling E., Salo M., Arkani S., Freedman J., Montan C., Lindqvist E.K., Elbe P., Hultgren R., Alga A., Nordberg M., Sandblom G., Holmner F., Lofgren N., Tampakis A., Kollmar O., von Fluee M., Balaphas A., Toso C., Colucci N., Popeskou S.G., Gass M., Scheiwiller A., Metzger J., Gialamas E., Chevallay M., Sauvain M., Dwidar O., Kiessling S.Y., Stoeckli S.J., Mongelli F., Bernasconi M., Di Giuseppe M., Christoforidis D., La Regina D., Arigoni M., Adamina M., Peros G., Guglielmetti L., Solimene F., Giardini M., Bachler T., Crugnale A.S., Gutschow C.A., Turina M., Ersen O., Onan M.A., Kozan R., Erol T., Dincer H.A., Yildiz A., Iflazoglu N., Yalkin O., Ozben V., Aytac E., Aliyeva Z., Akaydin E., Ozmen B.B., Baca B., Altinel Y., Calikoglu F., Tokocin M., Hacim N.A., Akbas A., Meric S., Vartanoglu T., Yigitbas H., Ercetin C., Ercan G., Ozgur I., Keskin M., Saracoglu K.T., Cimenoglu B., Demirhan R., Kale A., Simsek T., Gundogdu E.C., Abbasov A., Tanal M., Citgez B., Bozkurt E., Yetkin S.G., Mihmanli M., Alhamed A., Ergun S., Sanli A.N., Velidedeoglu M., OZcelik k M.F., 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Gammeri E., Catton A., Marinos Kouris S., Pereca J., Singh J., Seymour Z., Jones R., Leeson S., Peevor R., Lala A.K., Houlden C., Kahiu J., Hossain N., Hosny S., Patel P., Handa S., Kaushal M., Kler A., Reghuram V., Tezas S., Fairhurst K., Yates C., Mitchell S., Bunni J., Richards S., George R., Lee S.M., Phull J., Frost J., Burnard S., Crowley R., Airey A., Bevan K., Makin-Taylor R., Ong C.S., Callan R., Bloom O., Aljanadi F., Moawad N., Jones M., Gregg A., Jeganathan R., Pachl M., Martin B., Archer J.E., Odeh A., Siddaiah N., Singhal R., Naumann D.N., Karandikar S., Syed A., Tucker O.N., Alam R., Kalkat M., Mak J.K.C., Kulkarni R., Sharma N., Nankivell P., Tirotta F., Parente A., Breik O., Kisiel A., Cato L.D., Saeed S., Pathanki A.M., Almond M., Kamal M., Leung E.Y.L., Kaur R., Brett-Miller C., Buruiana F.E., Markose G., De Gea Rico A., Taib A., Myatt D., Sulaiman Khaled A., Younis F., Sultana A., Taggarsi M., Vitone L., Lambert J., Vaz O.P., Sarantitis I., Shrestha D., Timbrell S., 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Harrison-Phipps K., Pilling J., Okiror L., Routledge T., Mills L., Wali A., El-Boghdadly K., Saso S., Fehervari M., Ploski J., Ghaem-Maghami S., Spalding D., Rajagopal P., Pai M., Habib N., Hamrang-Yousefi S., Tayeh S., Chase T., Humphreys L., Ayorinde J., Ghanbari A., Cuming T., Anscomb N., Baldwin-Smith R., Rizk M., Grainger C., Davies M., Surendran A., Nunoo-Mensah J.W., Dunstan M., Beak P., Gerogiannis I., Jain A., Menon A., Pramodana B., Choi D., Marcus H.J., Webber L., May R., Hutchison R., Luoma V., Ranjit S., Parakh J., Sarodaya V., Daadipour A., Khalifa M., Bosch K.D., Bashkirova V., Dvorkin L.S., Kalidindi V.K., Dudek J., Singhal T., El-Hasani S., De Souza A., Cannoletta M., Rochon M., Bhudia S., Bennett S., Navaratne L., Venn M., Yip V., Kayani B., Sohrabi C., Kocher H.M., Minicozzi A., Banerjee A., Sullivan T., Sivaprakasam R., Anzak A., Ghufoor K., Thaha M.A., Knowles C., Ledesma F.S., Patki P., Popova D., Sadigh P., Ramamoorthy R., Uff C., Attwell L., Tanabalan C., Goh M.A., Jayasinghe J.D., Leal Silva I., Thakur B., Lebe M., Thet M.S., Hughes F., Rahman R., Fuwa O., Oo A., Bueser T., Curtis M., Stamenkovic S.A., Abbott T., Anwar S., Williams K., Chung E., Hagger R., Karim A., Hainsworth A., Flatman M., Trompeter A., Hing C., Tsinaslanidis P., Benjamin M.W., Leyte A., Tan C., Smelt J., Vaughan P., Santhirakumaran G., Hunt I., Raza M., Labib A., Luo X., Sudarsanam A., Rolls A., Lyons O., Onida S., Shalhoub J., Sugand K., Park C., Sarraf K.M., Erridge S., Kinross J., Denning M., Yalamanchili S., Abuown A., Ibrahim M., Martin G., Davenport D., Wheatstone S., Kasivisvanathan V., Kapriniotis K., Elhamshary A., Imam S.M.B., Kalavrezos N., Sinha D., Chand M., Green L., Beech N., McEwen R., Kiconco H., Andreani S.M., Bath M.F., Sahni A., Judkins N., Rigueros Springford L., Bacarese-Hamilton J., Taylor F.G., Parmar C., Mccluney S., Shah S., Talwar R., Patel K., Askari A., Jambulingam P.S., Shaw S., Maity A., Hatzantonis C., Sagar J., Kudchadkar S., Cirocchi 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T., Waheed S., Kapoor K., Belgaumkar A.P., Fahim M., Gala T., Mithany R., Morgan R., Abdelkarim M., Maw A., Asqalan A., Sundaram Venkatesan G., Singh S., Mukherjee S., Ferguson D., Mansuri A., Thakrar A., Wickramarachchi L., Cuthbert R., Sivayoganathan S., Chui K., Karam E., Dott C., Madhvani K., Hampton M., Hormis A.P., Fountain D.M., Laurente R., Sigamoney K.V., Dasa M., George K., Naqui Z., Galhoum M., Lipede C., Gabr A., Radhakrishnan A., Hasan M.T., Kalenderov R., Pathmanaban O., Chelva R., Branagan G., Longstaff L., Ding D., Barlow C., Foster J., Ward A., Tadross D., Majkowski L., Blundell C., Nair R., Guha S., Brown S.R., Steele C., Kelty C.J., Newman T., Lee M., Lye G., Balasubramanian S.P., Sureshkumar Shah N., Sherif M., Al-mukhtar A., Whitehall E., Giblin A., Sharkey A., Adamec A., Madan S., Narice B., Sterrenburg M., Thompson A., Varley I., Stavrakas M., Rominiyi O., Ray J., Crank M., Bacon A., Al-Tamimi Y., Catto J., Saad S., Abd Kahar N.N., Sou A., Simpson D., Hamilton E., Blair J., Jallad S., Lord J., Anderson C., El Kafsi J., Logishetty K., Saadya A., Midha R., Ip M., Subbiah Ponniah H., Stockdale T., Bacarese-Hamilton T., Foster L., James A., Anjarwalla N., Marujo Henriques D., Hettige R., Baban C., Tenovici A., Salerno G., Lane J., Colvin H.V., Badran A., Cadersa A., Cumpstey A., Hamady Z., Aftab R., Wensley F., Byrne J., Morrison-Jones V., Sekhon G.K., Shields H., Shakoor Z., Yener A., Talbot T., Alzetani A., Cresner R., Babu B.H.B., Liyanage A.S.D., Newman S., Blake I., Weerasinghe C., Baumber R., Parry J., Menakaya C., Webb J.I., Antar M., Modi N., Sofat R., Noel J., Nunn R., Adegbola S., Eriberto F., Sharma V., Tanna R., Lodhia S., Johnson D., Hughes I., Hall J., Rooney J., Chatterji S., Zhang Y., Owen R., Rudic M., Hunt J., Zakai D., Aladeojebi A., Ali M., Gaunt A., Barmayehvar B., Kitchen M., Gowda M., Mansour F., Jarvis M., Halliday E., Lefroy R., Nanjaiah P., Lin D.J., Rajgor A.D., Scurrah R.J., Kang C., Watson L.J., Harris G., Royle T., Cunningham Y., Steel B., Luk A.C.O., Boulton A.J., Bakolas G., Herrod P., Gemmill E., Boyd-Carson H., Jibreel M., Lenzi E., Saafan T., Sapre D., Li Z., Parkins K., Spencer N., Harries R., Egan R.J., Motter D., Jenvey C., Mahoney R., Fine N., Minto T., Henry A., Hollyman M., Grieco C., Gemmell C., Whitmore H., Babar M.S., Goodrum S., Scott R., Collard B., Lau K., Thomas E., Patel A., Allison J., Bowen J., Dias A., Mahendran B., Gopalswamy S., Patil S., Scott L., Sarveswaran J., Michel M., Ravindran S., Subba K., Abou-Foul A.K., Khalefa M., Hossain F., Moores T., Pickering L., Stables G., Doorgakant A., Thiruvasagam V.G., Carter J., Reid S., Mohammed R., Marlow W., Ferguson H., Wilkin R., Konstantinou C., Yershov D., Vatish J., Denning A., Shah H.B., Cross G.W.V., Seyed-Safi P., Smart Y.W., Kuc A., Al-Yaseen M., Olivier J., Hanna M., Eskander P., Duncan R., Halaseh S., Das R., Wynn Jones H., Divecha H., Whelton C., Board T., Powell S., Magee C., Agarwal K., Mangos E., Nambirajan T., Vidya R., Chauhan G., Kaur J., Burahee A., Bleibleh S., Pigadas N., Snee D., Bhasin S., Crichton A., Habeebullah A., Bodla A.S., Yassin N., Mondragon M., Dewan V., Flindall I., Mahendran V., Hanson A., Jenner E., Richards J., Thomas-Fernandez K., Wall R., Alqallaf A., Ben-Sassi A., Mellor K., Joshi P., Joshi Y., Young R., Miu V., Sheridan K., MacDonald L., Green S., Onos L., Wong J.J., Napolitano L., Hemmila M., Amin D., Abramowicz S., Roser S.M., Olson K.A., Riley C., Heron C., Cardenas T., Leede E., Thornhill M., Haynes A.B., McElhinney K., Roward S., Trust M.D., Hill C.E., Teixeira P.G., Etchill E., Stevens K., Ladd M.R., Long C., Rose J., Kent A., Yesantharao P., Vervoort D., Jenny H., Gabre-Kidan A., Margalit A., Tsai L., Malapati H., Yesantharao L., Abdou H., Diaz J., Richmond M., Clark J., O'Meara L., Hanna N., Ying Y., Fleming J., Ovaitt A., Gigliotti J., Fuson A., Cooper Z., Salim A., Hirji S.A., Chung C., Hansen L., Okafor B.U., Roxo V., Raut C.P., Jolissaint J.S., Mahvi D.A., Bankhead-Kendall B., Velmahos G., Maurer L.R., El Moheb M., Gaitanidis A., Naar L., Christensen M.A., Kapoen C., Langeveld K., El Hechi M., Mokhtari A., Haqqani M.H., Drake F.T., Goldenberg-Sandau A., Galbreath B., Reinke C., Ross S., Thompson K., Manning D., Perkins R., Eriksson E., Evans H., Masrur M., Giulianotti P., Benedetti E., Chang G., Ourieff J., Dehart D., Dorafshar A., Price T., Bhama A.R., Torquati A., Cherullo E., Kennedy R., Myers J., Rubin K., Ban V.S., Aoun S.G., Batjer H.H., Caruso J., Carmichael H., Velopulos C.G., Wright F.L., Urban S., McIntyre R.C., Schroeppel T.J., Hennessy E.A., Dunn J., Zier L., Burlew C., Coleman J., Colling K.P., Hall B., Rice H.E., Hwang E.S., Olson S.A., Moris D., Verma R., Hassan R., Volpe A., Merola S., O'Banion L.A., Lilienstein J., Dirks R., Marwan H., Almasri M., Kulkarni G., Mehdi M., Abouassi A., Abdallah M., San Andres M., Eid J., Aigbivbalu E., Sundaresan J., George B., Ssentongo A., Ssentongo P., Oh J.S., Hazelton J., Maines J., Gusani N., Garner M., Horvath S., Zheng F., Ujiki M., Kinnaman G., Meagher A., Sharma I., Holler E., McKenzie K., Chan J., Fretwell K., Nugent W., Khalil A., Chen D., Post N., Rostkowski T., Brahmbhatt D., Huynh K., Hibbard M.L., Schellenberg M., Martin R.C.G., Bhutiani N., Giorgakis E., Laryea J., Bhavaraju A., Sexton K., Kost M., Kimbrough M., Burdine L., Kalkwarf K., Robertson R., Gosain A., Camp L., Lewit R., Kronenfeld J.P., Urrechaga E., Goel N., Rattan R., Hart V., Gilna G., Cioci A., Ruiz G., Rakoczy K., Pavlis W., Saberi R., Morris R., Karam B.S., Brathwaite C.E.M., Liu H., Petrone P., Hakmi H., Sohail A.H., Baltazar G., Heckburn R., Nygaard R.M., Colonna E.T., Endorf F.W., Hill M.J., Maiga A., Dennis B., Levin J.H., Lallemand M., Choron R., Peck G., Soliman F., Rehman S., Glass N., Juthani B., Deisher D., Ruzgar N.M., Ullrich S.J., Sion M., Paranjape C., Kar A.R., Gillezeau C., Rapp J., Taioli E., Miles B.A., Alpert N., Podolsky D., Coleman N.L., Callahan M.P., Brown L., Monson J.R.T., Dehal A., Abbas A., Soliman A., Kim B., Jones C Dauer M.D.E., Renza-Stingone E., Hernandez E., Gokcen E., Kropf E., Sufrin H., Hirsch H., Ross H., Engel J., Sewards J., Poggio J., Sanserino K., Rae L., Philp M., Metro M., McNelis P., Petrov R., Pazionis T., Till B., Lamm R., Rios-Diaz A.J., Palazzo F., Rosengart M., Nicholson K., Carrick M.M., Rodkey K., Suri A., Callcut R., Nicholson S., Talathoti N., Klaristenfeld D., Biffl W., Marsh C., Schaffer K., Berndtson A.E., Averbach S., Curry T., Kwan-Feinberg R., Consorti E., Gonzalez R., Grolman R., Liu T., Merzlikin O., Abel M.K., Ozgediz D., Boeck M., Kornblith L.Z., Nunez-Garcia B., Robinson B., Park P., Utria A.F., Rice-Townsend S.E., Javid P., Hauptman J., Kieran K., Nehra D., Walters A., Cuschieri J., Davidson G.H., Cosker R., Eckhouse S., Choudhry A., Marx W., Jamil T., Seegert S., Al-Embideen S., Quintana M., Jackson H., Wexner S.D., Kent I., Martins P.N., Alshehari M., Al-Naggar H., Alsayadi M., Alyazidi M., Shream S., Alhaddad W., Maqus A., Abu Hamra'a M., Alsayadi R., Ghannam R., Al-Maqtari S., Masdoos S., Al-Harazi Y., Bajjah H., Al-ameri S., Aldawbali M., Gwini G.P., Collaborative, Cardiothoracic Interdisciplinary Research Network and COVIDSurg, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The Cardiothoracic Interdisciplinary Research Network and COVIDSurg Collaborative, Akowuah, E, Benson, R, Caruana, E, Chetty, G, Edwards, J, Forlani, S, Gradinariu, G, Murphy, G, Oo, A, Patel, A, Ridley, B, Rogers, L, Sanders, J, Tyson, N, Vaja, R, Siaw-Acheampong, K, Argus, L, Chaudhry, D, Dawson, B, Glasbey, J, Gujjuri, R, Jones, C, Kamarajah, S, Khatri, C, Keatley, J, Lawday, S, Li, E, Mann, H, Marson, E, Mclean, K, Picciochi, M, Taylor, E, Tiwari, A, Simoes, J, Trout, I, Venn, M, Wilkin, R, Bhangu, A, Nepogodiev, D, Dajti, I, Gjata, A, Boccalatte, L, Modolo, M, Cox, D, Pockney, P, Townend, P, Aigner, F, Kronberger, I, Hossain, K, Vanramshorst, G, Lawani, I, Ataide, G, Baiocchi, G, Buarque, I, Gohar, M, Slavchev, M, Agarwal, A, Brar, A, Martin, J, Olivos, M, Calvache, J, Perez Rivera, C, Hadzibegovic, A, Kopjar, T, Mihanovic, J, Klat, J, Novysedlak, R, Christensen, P, El-Hussuna, A, Batista, S, Lincango, E, Emile, S, Mengesha, M, Hailu, D, Tamiru, H, Kauppila, J, Laukkarinen, J, Arnaud, A, Albertsmeiers, M, Lederhuber, H, Loffler, M, Tabiri, S, Metallidis, S, Tsoulfas, G, Lorena, M, Grecinos, G, Mersich, T, Wettstein, D, Ghosh, D, Kembuan, G, Brouk, P, Khosravi, M, Mozafari, M, Adil, A, Mohan, H, Zmora, O, Fiore, M, Gallo, G, Pata, F, Pellino, G, Satoi, S, Ayasra, F, Chaar, M, Fakhradiyev, I, Jamal, M, Elhadi, M, Gulla, A, Roslani, A, Martinez, L, Ramos De La Medina, A, Outani, O, Jonker, P, Kruijff, S, Noltes, M, Steinkamp, P, van der Plas, W, Ademuyiwa, A, Osinaike, B, Seyi-olajide, J, Williams, E, Pejkova, S, Augestad, K, Soreide, K, Al Balushi, Z, Qureshi, A, Sayyed, R, Mohsen Daraghmeh, M, Abukhalaf, S, Cukier, M, Gomez, H, Shu, S, Vasquez, X, Parreno-Sacdalan, M, Major, P, Azevedo, J, Cunha, M, Santos, I, Zarour, A, Bonci, E, Negoi, I, Efetov, S, Litvin, A, Ntirenganya, F, Alameer, E, Radenkovic, D, Hong Xiang, F, Hoe, C, Chi Yong, J, Moore, R, Nhlabathi, N, Colino, R, Bravo, A, Minaya-Bravo, A, Jayarajah, U, Wickramasinghe, D, Elmujtaba, M, Jebril, W, Rutegard, M, Sund, M, Isik, A, Leventoglu, S, Abbott, T, Caruna, E, Chakrabortee, S, Demetriades, A, Desai, A, Drake, T, Evans, J, Ford, S, Fotopoulou, C, Griffiths, E, Hutchinson, P, Jenkinson, M, Khan, T, Knight, S, Kolias, A, Leung, E, Mckay, S, Norman, L, Ots, R, Raghavan, V, Roberts, K, Schache, A, Shaw, R, Shaw, K, Smart, N, Stewart, G, Sundar, S, Vimalchandran, D, Wright, N, Alshryda, S, Alser, O, Breen, K, Ganly, I, Kaafarani, H, Kendall, B, Mashbari, H, Al Naggar, H, Mazingi, D, Valenzuela, J, Gemelli, N, Smith, D, Dudi-Venkata, N, Kroon, H, Sammour, T, Roberts, M, Mitchell, D, Lah, K, Pearce, A, Morton, A, Dawson, A, Drane, A, Sharpin, C, Nataraja, R, Pacilli, M, Muralidharan, V, Riddiough, G, Clarke, E, Jamel, W, Qin, K, Cope, D, Egoroff, N, Lott, N, Putnis, S, De Robles, S, Ang, Z, Mitteregger, M, Uranitsch, S, Stiegler, M, Seitinger, G, Lumenta, D, Nischwitz, S, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, T, Messner, F, Ofner, D, Presl, J, Varga, M, Weitzendorfer, M, Emmanuel, K, Binder, A, Zimmermann, M, Holawe, S, Nkenke, E, Grimm, C, Kranawetter, M, Rahman Mitul, A, Islam, N, Karim, S, Komen, N, Ang, E, De Praetere, H, Tollens, T, Schols, G, Smets, C, Haenen, L, Quintens, J, Van Belle, K, Van Ramshorst, G, Pattyn, P, Desender, L, Martens, T, Van de putte, D, Lerut, P, Grimonprez, A, Janssen, M, De Smul, G, Wallaert, P, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Duchateau, N, De Gheldere, C, Flamey, N, Christiano, A, Guidi, B, Minussi, A, Castro, S, Okoba, W, Maldonado, F, Oliveira, P, Baldasso, T, Santos, L, Gomes, G, Pol-Fachin, L, Bezerra, T, Barros, A, da Silva, A, Leite, A, Silvestre, D, Ferro, C, Araujo, M, Lopes, L, Damasceno, P, Araujo, D, Laporte, G, Salem, M, Guimaraes-Filho, M, Nacif, L, Flumignan, R, Nakano, L, Kuramoto, D, Aidar, A, Pereda, M, Correia, R, Santos, B, Carvalho, A, Amorim, J, Guedes Neto, H, Areias, L, Sousa, A, Flumignan, C, Lustre, W, Moreno, D, Barros, N, Baptista-Silva, J, Matos, L, Kowaski, L, Kulcsar, M, Nunes, K, Teixeira, M, Nunes, R, Ijichi, T, Kim, N, Marreiro, A, Muller, B, Barakat Awada, J, Kowalski, L, Vartanian, J, Makdissi, F, Aguiar, S, Marques, N, Carvalho, G, Marques, T, Abdallah, E, Zurstrassen, C, Gross, J, Zequi, S, Goncalves, B, Santos, S, Duprat, J, Coimbra, F, Cicco, R, Takeda, F, Cecconello, I, Ribeiro, U, Gatti, A, Oliva, R, Nardi, C, Atanasov, B, Belev, N, Dell, A, Bigam, D, Dajani, K, Al Riyami, S, Cheng, D, Yang, H, Fayad, A, Carrier, F, Amzallag, E, Desroches, J, Ruel, M, Caminsky, N, Boutros, M, Moon, J, Wong, E, Vanounou, T, Pelletier, J, Wong, S, Girsowicz, E, Bayne, J, Obrand, D, Gill, H, Steinmetz, O, Mackenzie, K, Lukaszewski, M, Jamjoum, G, Richebe, P, Verdonck, O, Discepola, S, Godin, N, Idrissi, M, Briatico, D, Sharma, S, Talwar, G, Bailey, K, Lecluyse, V, Cote, G, Demyttenaere, S, Garfinkle, R, Kouyoumdjian, A, Dumitra, S, Khwaja, K, Luo, L, Berry, G, Liberman, A, Schmid, S, Spicer, J, Al Farsi, M, Abou-Khalil, J, Couture, E, Mohammadi, S, Tremblay, H, Gagne, N, Bergeron, A, Turgeon, A, Costerousse, O, Bellemare, D, Babin, C, Blier, C, Wood, M, Persad, A, Groot, G, Pham, H, D'Aragon, F, Carbonneau, E, Bouchard, M, Masse, M, Pesant, F, Heroux, J, Karanicolas, P, Hallet, J, Nadler, A, Nathens, A, Ko, M, Mayson, K, Kidane, B, Srinathan, S, Escudero, M, Reyes, J, Ramirez Nieto, P, Sepulveda, R, Bolbaran, A, Molero, A, Ruiz, I, Reyes, G, Salas, R, Suazo, C, Munoz, R, Grasset, E, Inzunza, M, Besser, N, Irarrazaval, M, Jarry, C, Bellolio, F, Romero Manqui, C, Ruiz Esquide, M, Fuentes, T, Campos, J, Cabrera, P, Pinilla, R, Guevara, O, Jimenez Ramirez, L, Velasquez Cuasquen, B, Herrera Mora, D, Bonilla, A, Diaz, S, Manrique, E, Facundo, H, Velez Bernal, J, Angel, J, Garcia, M, Guzman, L, Lehmann, C, Cervera, S, Trujillo Sanchez, L, Guevara, R, Valbuena, D, Suarez, L, Jimenez, G, Velandia, A, Vargas, J, Espinosa, J, Rey, S, Mendoza Quevedo, J, Orozco-Chamorro, C, Sanchez-Gomez, T, Rojas-Tejada, D, Bakmaz, B, Rakvin, I, Sulen, N, Andabaka, T, Luksic, I, Mamic, M, Martinek, L, Skrovina, M, Zatecky, J, Peteja, M, Kristensen, H, Mekhael, M, Westh, L, Smith, H, Haugstvedt, A, Jonsson, M, Crespo, A, Rodriguez-Abreu, J, Tactuk, N, Diaz-Delgado, P, Rivas, R, Sarmiento-Bobadilla, J, Ashoush, F, Samir Abdelaal, A, Qatora, M, Elsayed Hewalla, M, Metwalli, M, Atta, R, Abdelmajeed, A, Abosamak, N, Sabry, A, Shehata, S, Sallam, I, Amira, G, Sherief, M, Sherif, A, Salem, H, Hamdy, R, Aboulkassem, H, Ghaly, G, Sherif, G, Morsi, A, Abdelrahman, A, Omnia, A, Tawheed, A, El Kassas, M, Omar, W, Abdelsamed, A, Seleim, A, Azzam, A, Elfiky, M, Nabil, A, Ibraheem, M, Eldeeb, M, Fawzy, M, Hamed, H, Elfallal, A, Elfeki, H, Shalaby, M, Sakr, A, Alrahawy, M, Atif, H, Soltan, H, Sayed, A, Salah, A, Atiya, A, Wassim, K, Abbas, A, Abd Elazeem, H, Abd-Elkariem, A, Abd-Elkarem, M, Alaa, S, Ali, A, Ashraf, M, Ayman, A, Azizeldine, M, Elkhayat, H, Emad Mashhour, A, Gaber, M, Hamza, H, Hawal, I, Hetta, H, Elghazaly, S, Mohammed, M, Monib, F, Nageh, M, Saad, A, Saad, M, Shahine, M, Yousof, E, Youssef, A, Esmail, E, Khalaf, M, Eldaly, A, Ghoneim, A, Hawila, A, Badr, H, Elhalaby, I, Abdel-bari, M, Elbahnasawy, M, Hamada, M, Morsy, M, Hammad, M, Essa, M, Fayed, M, Elzoghby, M, Rady, M, Hamad, O, Salman, S, Sarsik, S, Abd-elsalam, S, Gamal Badr, S, El-Masry, Y, Moahmmed, M, Hailu, S, Wolde, A, Nida, S, Workneh, M, Y Ahmed, M, Fisseha, T, Kassa, D, Zeleke, H, Admasu, A, Laeke, T, Tirsit, A, Gessesse, M, Addissie, A, Bekele, D, Sarjanoja, E, Testelin, S, Dakpe, S, Devauchelle, B, Bettoni, J, Lavagen, N, Schmitt, F, Lemee, J, Boucher, S, Breheret, R, Kun-Darbois, J, Kahn, A, Gueutier, A, Bigot, P, Borraccino, B, Lakkis, Z, Doussot, A, Heyd, B, Manfredelli, S, Mathieu, P, Paquette, B, Turco, C, Barrabe, A, Louvrier, A, Moszkowicz, D, Giovinazzo, D, Bretagnol, F, Police, A, Charre, L, Volpin, E, Braham, H, El Arbi, N, Villefranque, V, Bendjemar, L, Girard, E, Abba, J, Trilling, B, Chebaro, A, Lecolle, K, Truant, S, El Amrani, M, Zerbib, P, Pruvot, F, Mathieu, D, Surmei, E, Mattei, L, Marin, H, Christou, N, Ballouhey, Q, Ferrero, P, Coste Mazeau, P, Tricard, J, Barrat, B, Taibi, A, Usseglio, J, 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Gjata, Arben, Boccalatte, Lui, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohane, Hailu, Dr.Samuel, Tamiru, Hailu, Kauppila, Joona, Laukkarinen, Johanna, Arnaud, Alexi, Albertsmeiers, Marku, Lederhuber, Han, Loffler, Marku, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgio, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tama, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Fari, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moise, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andrea, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelo, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Denni, Simoes, Joana F.F., Dajti, I., Valenzuela, J.I., Boccalatte, L.A., Gemelli, N.A., Smith, D.E., Dudi-Venkata, N.N., Kroon, H.M., Sammour, T., Roberts, M., Mitchell, D., Lah, K., Pearce, A., Morton, A., Dawson, A.C., Drane, A., Sharpin, C., Nataraja, R.M., Pacilli, M., Cox, D.R.A., Muralidharan, V., Riddiough, G.E., Clarke, E.M., Jamel, W., Qin, K.R., Pockney, P., Cope, D., Egoroff, N., Lott, N., Putnis, S., De Robles, S., Ang, Z., Mitteregger, M., Uranitsch, S., Stiegler, M., Seitinger, G., Aigner, F., Lumenta, D.B., Nischwitz, S.P., Richtig, E., Pau, M., Srekl-Filzmaier, P., Eibinger, N., Michelitsch, B., Fediuk, M., Papinutti, A., Seidel, G., Kahn, J., Cohnert, T.U., Messner, F., Öfner, D., Presl, J., Varga, M., Weitzendorfer, M., Emmanuel, K., Binder, A.D., Zimmermann, M., Holawe, S., Nkenke, E., Grimm, C., Kranawetter, M., Rahman Mitul, A., Islam, N., Karim, S., Komen, N., Ang, E., De Praetere, H., Tollens, T., Schols, G., Smets, C., Haenen, L., Quintens, J., Van Belle, K., Van Ramshorst, G.H., Pattyn, P., Desender, L., Martens, T., Van de putte, D., Lerut, P., Grimonprez, A., Janssen, M., De Smul, G., Wallaert, P., Van den Eynde, J., Oosterlinck, W., Van den Eynde, R., Sermon, A., Boeckxstaens, A., Cordonnier, A., De Coster, J., Jaekers, J., Politis, C., Miserez, M., Duchateau, N., De Gheldere, C., Flamey, N., Christiano, A., Guidi, B., Minussi, A.L., Castro, S., Okoba, W., Maldonado, F.H.R., Oliveira, P., Baldasso, T., Santos, L., Gomes, G.M.A., Buarque, I.L., Pol-Fachin, L., Bezerra, T.S., Barros, A.V., da Silva, A.M.R., Leite, A.L.S., Silvestre, D.W.A., Ferro, C.C., Araujo, M.S., Lopes, L.M., Damasceno, P.D., Araujo, D.H.S., Laporte, G., Salem, M.C., Guimaraes-Filho, M.A.C., Nacif, L., Flumignan, R.L.G., Nakano, L.C.U., Kuramoto, D.A.B., Aidar, A.L.S., Pereda, M.R., Correia, R.M., Santos, B.C., Carvalho, A.A., Amorim, J.E., Guedes Neto, H.J., Areias, L.L., Sousa, A.F., Flumignan, C.D.Q., Lustre, W.G., Moreno, D.H., Barros, N., Baptista-Silva, J.C.C., Matos, L.L., Kowaski, L.P., Kulcsar, M.A.V., Nunes, K.S., Teixeira, M.F., Nunes, R.L., Ijichi, T.R., Kim, N.J., Marreiro, A., Muller, B., Barakat Awada, J., Baiocchi, G., Kowalski, L.P., Vartanian, J.G., Makdissi, F.B., Aguiar, S., Marques, N., Carvalho, G.B., Marques, T.M.D.M., Abdallah, E.A., Zurstrassen, C.E., Gross, J.L., Zequi, S.C., Gonçalves, B.T., Santos, S.S., Duprat, J.P., Coimbra, F.J.F., Cicco, R., Takeda, F., Cecconello, I., Ribeiro, U., Gatti, A., Oliva, R., Nardi, C., Slavchev, M., Atanasov, B., Belev, N., Dell, A., Bigam, D., Dajani, K., Al Riyami, S., Martin, J., Cheng, D., Yang, H., Fayad, A., Carrier, F.M., Amzallag, E., Desroches, J., Ruel, M., Caminsky, N.G., Boutros, M., Moon, J., Wong, E.G., Vanounou, T., Pelletier, J., Wong, S., Girsowicz, E., Bayne, J., Obrand, D., Gill, H., Steinmetz, O., MacKenzie, K., Lukaszewski, M., Jamjoum, G., Richebé, P., Verdonck, O., Discepola, S., Godin, N., Idrissi, M., Briatico, D., Sharma, S., Talwar, G., Bailey, K., Lecluyse, V., Côté, G., Demyttenaere, S., Garfinkle, R., Kouyoumdjian, A., Dumitra, S., Khwaja, K., Luo, L., Berry, G., Liberman, A.S., Schmid, S., Spicer, J., Al Farsi, M., Abou-Khalil, J., Couture, E., Mohammadi, S., Tremblay, H., Gagné, N., Bergeron, A., Turgeon, Af, Costerousse, O., Bellemare, D., Babin, C., Blier, C., Wood, M.L., Persad, A., Groot, G., Pham, H., D'Aragon, F., Carbonneau, E., Bouchard, M., Masse, M., Pesant, F., Héroux, J., Karanicolas, P., Hallet, J., Nadler, A., Nathens, A., Ko, M., Brar, A., Mayson, K., Kidane, B., Srinathan, S., Escudero, M.I., Reyes, J.T., Modolo, M.M., Ramirez Nieto, P., Sepulveda, R., Bolbarán, A., Molero, A., Ruiz, I., Reyes, G.P., Salas, R., Suazo, C., Muñoz, R., Grasset, E., Inzunza, M., Besser, N., Irarrázaval, M.J., Jarry, C., Bellolio, F., Romero Manqui, C.A., Ruiz Esquide, M., Fuentes, T., Campos, J., Perez Rivera, C.J., Cabrera, P.A., Pinilla, R.E., Guevara, O., Jimenez Ramirez, L.J., Velasquez Cuasquen, B.G., Herrera Mora, D.R., Bonilla, A., Diaz, S., Manrique, E., Facundo, H., Velez Bernal, J.L., Ángel, J., García, M., Guzmán, L., Lehmann, C., Cervera, S., Trujillo Sanchez, L.M., Guevara, R., Valbuena, D., Suarez, L., Jimenez, G., Velandia, A., Vargas, J., Espinosa, J., Rey, S., Mendoza Quevedo, Jairo, Calvache, J.A., Orozco-Chamorro, C.M., Sánchez-Gómez, T.A., Rojas-Tejada, D.A., Mihanovic, J., Bakmaz, B., Rakvin, I., Sulen, N., Andabaka, T., Luksic, I., Mamic, M., Martinek, L., Skrovina, M., Žatecký, J., Peteja, M., Kristensen, H.Ø., Mekhael, M., Christensen, P., Westh, L., Smith, H., Haugstvedt, A.F., Jönsson, M.L., Crespo, A., Batista, S., Rodriguez-Abreu, J., Tactuk, N., Diaz-Delgado, P.J., Rivas, R., Sarmiento-Bobadilla, J.A., Ashoush, F., Samir Abdelaal, A., Qatora, M.S., Elsayed Hewalla, M.E., Metwalli, M., Atta, R., Abdelmajeed, A., Abosamak, N.E., Sabry, A., Shehata, S., Sallam, I., Amira, G., Sherief, M., Sherif, A., Salem, H., Hamdy, R., Aboulkassem, H., Ghaly, G., Sherif, G., Morsi, A., Abdelrahman, A., Omnia, Ahmed, Tawheed, A., El Kassas, M., Omar, W., Abdelsamed, A., Seleim, A., Azzam, A.Y., ElFiky, M., Nabil, A., Ibraheem, M., ELDeeb, M., Fawzy, M., Hamed, H., Emile, S., Elfallal, A., Elfeki, H., Shalaby, M., Sakr, A., Alrahawy, M., Atif, H., Soltan, H., Sayed, A.K., Salah, A., Atiya, A., Wassim, K., Abbas, A.M., Abd Elazeem, H.A.S., Abd-Elkariem, A.Y., Abd-Elkarem, M.M., Alaa, S., Ali, A.K., Ashraf, M., Ayman, A., Azizeldine, M.G., Elkhayat, H., Emad Mashhour, A., Gaber, M., Hamza, H.M., Hawal, I., Hetta, H.F., Elghazaly, S.M., Mohammed, M.M., Monib, F.A., Nageh, M.A., Saad, A., Saad, M.M., Shahine, M., Yousof, E.A., Youssef, A., Esmail, E., Khalaf, M., Eldaly, A., Ghoneim, A., Hawila, A., Badr, H., Elhalaby, I., Abdel-bari, M., Elbahnasawy, M., Hamada, M.K., Morsy, M.S., Hammad, M., Essa, M., Fayed, M.T., Elzoghby, M., Rady, M., Hamad, O., Salman, S., Sarsik, S., Abd-elsalam, S., Gamal Badr, S., El-Masry, Y., Moahmmed, M.M.H., Hailu, S., Wolde, A., Mengesha, M., Nida, S., Workneh, M., Y Ahmed, M., Fisseha, T., Kassa, D., Zeleke, H., Admasu, A., Laeke, T., Tirsit, A., Gessesse, M., Addissie, A., Bekele, D., Kauppila, J.H., 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Kantor, E., Gossot, D., Seguin-Givelet, A., Fuks, D., Grigoroiu, M., Sanchez Salas, R., Cathelineau, X., Macek, P., Barbé, Y., Rozet, F., Barret, E., Mombet, A., Cathala, N., Brian, E., Zadegan, F., Conso, C., Blanc, T., Broch, A., Sarnacki, S., Ali, L., Bonnard, A., Peycelon, M., Hervieux, E., Clermidi, P., Maisonneuve, E., Aubry, E., Thomin, A., Langlais, T., Passot, G., Glehen, O., Cotte, E., Lifante, J.C., De Simone, B., Chouillard, E., Arnaud, A.P., Violas, P., Bergeat, D., Merdrignac, A., Scalabre, A., Perotto, L.O., Le Roy, B., Haddad, E., Vermersch, S., Ezanno, A.C., Barbier, O., Vigouroux, F., Malgras, B., Aime, A., Seeliger, B., Mutter, D., Philouze, G., Pessaux, P., Germain, A., Chanty, H., Ayav, A., Kassir, R., Von theobald, P., Sauvat, F., O'Connor, J., Mayombo Idiata, M., O'Connor, Z., Tchoba, S., Modabber, A., Winnand, P., Hölzle, F., Sommer, B., Shiban, E., Wolf, S., Anthuber, M., Sommer, F., Kaemmerer, D., Schreiber, T., Kamphues, C., Lauscher, J.C., Schineis, C., 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F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C.V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M.N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A.L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M.G., Lippa, L., 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Cenciarelli, S., Adamoli, L., Ansarin, M., Fumagalli Romario, U., Mastrilli, F., Mariani, N.M., Nicastro, V., Cellerino, P., Colombo, F., Frontali, A., Bondurri, A., Guerci, C., Maffioli, A., Ferrario, L., Candiani, M., Bonavina, G., Ottolina, J., Valsecchi, L., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Negri, G., Bandiera, A., De Nardi, P., Sileri, P., Carlucci, M., Pelaggi, D., Rosati, R., Vignali, A., Parise, P., Elmore, U., Tamini, N., Nespoli, L.C., Rennis, M., Pitoni, L., Chiappetta, M.F., Vico, E., Fruscio, R., Grassi, T., Sasia, D., Migliore, M., Gattolin, A., Rimonda, R., Travaglio, E., Olearo, E., Tufo, A., Marra, E., Maida, P., Marte, G., Tammaro, P., Incollingo, P., Izzo, F., Belli, A., Patrone, R., Albino, V., Leongito, M., Granata, V., Piccirillo, M., Palaia, R., Francone, E., Gentilli, S., Nikaj, H., Fiorini, A., Norcini, C., Chessa, A., Marino, M.V., Mirabella, A., Vaccarella, G., Musini, L., Ampollini, L., Bergonzani, M., Varazzani, A., Bellanti, L., Domenichini, M., Cabrini, E., Fornasari, A., Freyrie, A., Dejana, D.O., D'Angelo, G., Bertoli, G., Di Lella, F., Bocchialini, G., Falcioni, M., Lanfranco, D., Poli, T., Giuffrida, M., Annicchiarico, A., Perrone, G., Catena, F., Raffaele, A., De Manzoni Garberini, A., Baldini, E., Conti, L., Ribolla, M., Capelli, P., Isolani, S.M., Maniscalco, P., Cauteruccio, M., Ciatti, C., Puma Pagliarello, C., Gattoni, S., Galleano, R., Malerba, M., Ciciliot, M., Farnesi, F., Calabrò, M., Pipitone Federico, N.S., Lunghi, E.G., Muratore, A., Di Franco, G., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Simoncini, T., Gadducci, A., Caretto, M., Giannini, A., Perutelli, A., Domenici, L., Garibaldi, S., Capanna, R., Andreani, L., Furbetta, N., Guadagni, S., Bianchini, M., Gianardi, D., Pinotti, E., Montuori, M., Carissimi, F., Baronio, G., Zizzo, M., Castro Ruiz, C., Annessi, V., Montella, M.T., Falco, G., Mele, S., Ferrari, G., Mastrofilippo, V., Mandato, V.D., Aguzzoli, L., Corbellini, C., Baldi, C., Sampietro, G.M., Palini, G.M., Zanini, N., Garulli, G., Barone, R., Murgese, A., Mungo, S., Grasso, M., Marafante, C., Birolo, S.L., Moggia, E., Caccetta, M., Masciandaro, A., Deirino, A., Garino, M., Perinotti, R., Maiello, F., Gordini, L., Lombardi, C.P., Marzi, F., Marra, A.A., Ratto, C., Di Muro, M., Litta, F., De Simone, V., Cozza, V., Rosa, F., Agnes, A., Parello, A., Alfieri, S., Sganga, G., Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G.B., Cicerchia, P.M., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Sagnotta, A., Marino Cosentino, L., Mancini, S., Lisi, G., Spoletini, D., Bellato, V., Campanelli, M., Sica, G., Siragusa, L., Bonavina, L., Asti, E., Bernardi, D., Lovece, A., Perra, T., Porcu, A., Fancellu, A., Feo, C.F., Scanu, A.M., Tuminello, F., Franceschi, A., Langone, A., Fleres, F., Spolini, A., Bordoni, P., Franzini, M., Clarizia, G., Grechi, A., Longhini, A., Guaitoli, E., Manca, G., Grossi, U., Novello, S., Zanus, G., Romano, M., Rossi, S., Ferrara, F., La Torre, M., Pirozzolo, G., Recordare, A., Paiella, S., Turri, G., Rattizzato, S., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Ruzzenente, A., Poletto, E., Conci, S., Casetti, L., Fontana, M., Salvia, R., Malleo, G., Esposito, A., Landoni, L., De Pastena, M., Bassi, C., Tuveri, M., Nobile, S., Marchegiani, G., Bortolasi, L., Sambugaro, E., Malavolta, M., Moretto, G., Impellizzeri, H., Inama, M., Barugola, G., Ascari, F., Ruffo, G., Granieri, S., Cotsoglou, C., Berselli, M., Desio, M., Marchionini, V., Cocozza, E., Di Saverio, S., Ietto, G., Iovino, D., Carcano, G., Ayasra, F., Qasem, A., Ayasra, Y., Al-Masri, M., Abou Chaar, M.K., Al-Najjar, H., Ghandour, K., Alawneh, F., Abdel Jalil, R., Abdel Al, S., Elayyan, M., Ghanem, R., Lataifeh, I., Alsaraireh, O., Abu Za’nouneh, F.J., Fahmawee, T., Ibrahim, A., Obeidat, K., Lee, K.J., Shin, S.J., Chung, H., Albader, I., Alabbad, J., Albader, M.A.S., Bouhuwaish, A., Taher, A.S., Omar, M.S.M., Abdulwahed, E., Biala, M., Morgom, M., Elhadi, A., Alarabi, A., Msherghi, A., Elhajdawe, F., Alsoufi, A., Salamah, A., Salama, H., Bulugma, M., Almabrouk, H., Venskutonis, D., Dainius, E., Kubiliute, E., Bradulskis, S., Parseliunas, A., Kutkevicius, J., Subocius, A., Cheong, Y.J., Masood, M.S., Ngo, C.W., Saravanan, R., Abdul Maei, N., Hayati, F., Amin Sahid, N., Yanowsky Reyes, G., Orozco Perez, J., Damian, R., Santana Ortiz, R., Colunga Tinajero, C.A., Cordera, F., Gómez-Pedraza, A., Maffuz-Aziz, A., Posada, J.A., De la Rosa Abaroa, M.A., Alvarez, M.R., Arrangoiz, R., Hernández, R., Bozada Gutierrez, K., Trejo-Avila, M., Valenzuela-Salazar, C., Herrera-Esquivel, J., Moreno-Portillo, M., Pinto-Angulo, V.M., Sosa-Duran, E.E., Ziad-Aboharp, H., Jimenez Villanueva, X., Soulé Martínez, C.E., Lupián-Angulo, A.I., Martínez Zarate J, Jacobo, Reyes Rodriguez, E., Montalvo Dominguez, G., Becerra García, F.C., Melchor-Ruan, J., Vilar-Compte, D., Romero-Bañuelos, E., Herrera-Gomez, A., Meneses-Garcia, A., Isla-Ortiz, D., Salcedo-Hernández, R.A., Hernández-Nava, J.M., Morales-Castelan, J.E., Posadas-Trujillo, O.E., Buerba, G.A., Alfaro-Goldaracena, A., Pena Gomez-Portugal, E., Lopez-Pena, G., Hinojosa, C.A., Mercado, M.A., Ramos-De la Medina, A., Martinez, L., Duran, I., Gonzalez, D.S., Martinez, M.J., Nayen Sainz de la Fuente, A., Miguelena, L., Hernández Miguelena, L., Louraoui, S.M., El Azhari, A., Rghioui, M., Khya, E., Ghannam, A., Souadka, A., El Ahmadi, B., Belkhadir, Z.H., Majbar, M.A., Benkabbou, A., Mohsine, R., Oudrhiri, M.Y., Bechri, H., Arkha, Y., El Ouahabi, A., Frima, H., Bachiri, S., Groen, L.C., Verhagen, T., ter Brugge, F.M., Scheijmans, J.C.G., Boermeester, M.A., Hompes, R., Meima-van Praag, E.M., Sharabiany, S., Borgstein, A.B.J., Gisbertz, S.S., van Berge Henegouwen, M.I., Gans, S., Van Duijvendijk, P., Herklots, T., De Hoop, T., De Graaff, M.R., Sloothaak, 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Sudarsanam, A., Rolls, A., Lyons, O., Onida, S., Shalhoub, J., Sugand, K., Park, C., Sarraf, K.M., Erridge, S., Kinross, J., Denning, M., Yalamanchili, S., Abuown, A., Ibrahim, M., Martin, G., Davenport, D., Wheatstone, S., Kasivisvanathan, V., Kapriniotis, K., Elhamshary, A., Imam, S.M.B., Kalavrezos, N., Sinha, D., Chand, M., Green, L., Beech, N., McEwen, R., Kiconco, H., Andreani, S.M., Bath, M.F., Sahni, A., Judkins, N., Rigueros Springford, L., Bacarese-Hamilton, J., Taylor, F.G., Parmar, C., Mccluney, S., Shah, S., Talwar, R., Patel, K., Askari, A., Jambulingam, P.S., Shaw, S., Maity, A., Hatzantonis, C., Sagar, J., Kudchadkar, S., Cirocchi, N., Chan, C.H., Reynolds, J., Alexander, M.E., Smart, C.J., Jayasankar, B., Balasubramaniam, D., Abdelsaid, K., Mundkur, N., Gallagher, B., Shah, J., Anthoney, J., Emmerson, O., Stylianides, N., Abdalla, M., Newton, K., Bhatia, K., Edmondson, R., Abdeh, L., Jones, D., Zeiton, M., Ismail, O., Naseem, H., Advani, R., Duff, S., Moura, F., Brown, B.C., Khan, A., Asaad, P., Wadham, B., Aneke, I.A., Collis, J., Warburton, H., Fell, A., Smith, A., Halkias, C., Nikolaou, S., English, C., Kristinsson, S., Oni, T., Ilahi, N., Ballantyne, K., Woodward, Z., Merh, R., Dunning, J., Viswanath, Y., Freystaetter, K., Dixon, J., Hadfield, J.N., Hilley, A., Egglestone, A., Smith, B., Hine, T., Keeler, B., Soulsby, R.E., Taylor, A., Davies, E., Ryska, O., Raymond, T., Rogers, S., Tong, A., Hawkin, P., Tingle, S., Abbadessa, F., Sachdeva, A., Rai, B., Chan, C.D., McPherson, I., Booth, K., Mahmoud Ali, F., Pandanaboyana, S., Grainger, T., Nandhra, S., Patience, A., Roy, C., Williams, T., Dawe, N., McCaffer, C., Riches, J., Bhattacharya, S., Moir, J., Kalson, N.S., Elamin Ahmed, H., Mellor, C., Saleh, C., Koshy, R.M., Hammond, J., Sanderson, L., Wahed, S., Phillips, A.W., Ghosh, K., Tang, A., Beamish, A.J., Price, C., Bosanquet, D., Magowan, D., Solari, F., Williams, G., Nassa, H., Smith, L., Robertson-Smith, B., Mahmoud, A., Ameerally, P., Finch, J.G., Gnanachandran, C., Pop, I., Rogers, M., Yousef, Y., Mohamed, I., Woods, R., Zahid, H., Mundy, G., Sreedharan, L., Baskaran, D., Shaikh, I., Seebah, K., Reid, J., Watts, D., Kouritas, V., Chrastek, D., Maryan, G., Gill, D.F., Khatun, F., Gajjar, K., Williamson, K., Bratt, D., Konstantinidi, K., Walton, T., Burnside, N., Weaver, H., Hawari, M., Addae-Boateng, E., Rollett, R.A., Collins, M.L., Tamimy, M.S., Riyat, H., Wen, J., Neil-Dwyer, J., Brewer, H., Humes, D., Worku, D., Chowdhury, A., Oyende, O., Lewis-Lloyd, C., Adiamah, A., Koh, A., Jackman, J., Vohra, R., Navarro, A., Reilly, J., Aujayeb, A., Townshend, D., McLarty, N., Shenfine, A., Jackson, K., Johnson, C., Dass, D., Ford, D., Winter, S.C., Belcher, E., Stavroulias, D., Di Chiara, F., Wallwork, K., Qureishi, A., Lami, M., Sravanam, S., Mastoridis, S., Shah, K., Chidambaram, S., Smillie, R., Shaw, A.V., Bandyopadhyay, S., Cernei, C., Bretherton, C., Jeyaretna, D., Ganau, M., Piper, R.J., Duck, E., Brown, S., Jelley, C., Tucker, S.C., Bond-Smith, G., Griffin, X.L., Tebala, G.D., Neal, N., Vatish, M., Noton, T.M., Ghattaura, H., Maher, M., Fu, H., Risk, O.B.F., Soleymani majd, H., Sinha, S., Shankar, S., Aggarwal, A., Kharkar, H., Lakhoo, K., Verberne, C., Dean, B., Luney, C., Myatt, R., Williams, M.A., McVeigh, J., Rogers, L.J., Labib, P.L., Miller, D., Minto, G., Hope, N., Marchbank, A., Emslie, K., Panahi, P., Ho, B., Perkins, C., Clough, E., Roy, H., Enemosah, I., Campbell, R., Natale, J., Gohil, K., Rela, M., Raza, N., Biliatis, I., Khan, J., Thiruchandran, G., Toh, S.K.C., Ahmad, Y., Allana, A., Bellis, C., Babawale, O., Phan, Y.C., Lokman, U., Ismail, M., Koc, T., Witek, A., Duggleby, L., Shamoon, S., Stefan, S., Clancy, H., Chadha, R., Middleton, S.B., Wilmott, K., Hayden, C., Mclaren, C., Sutton, J., Whyte, A., Belgaumkar, A., Day, A., Gilbert, C., Oyewole, B., Narayan, P., Dent, H., Sandhya, A., De Silva, T., Waheed, S., Kapoor, K., Belgaumkar, A.P., Fahim, M., Gala, T., Mithany, R., Morgan, R., Abdelkarim, M., Maw, A., Asqalan, A., Sundaram Venkatesan, G., Singh, S., Mukherjee, S., Ferguson, D., Mansuri, A., Thakrar, A., Wickramarachchi, L., Cuthbert, R., Sivayoganathan, S., Chui, K., Karam, E., Dott, C., Madhvani, K., Hampton, M., Hormis, A.P., Fountain, D.M., Laurente, R., Sigamoney, K.V., Dasa, M., George, K., Naqui, Z., Galhoum, M., Lipede, C., Gabr, A., Radhakrishnan, A., Hasan, M.T., Kalenderov, R., Pathmanaban, O., Chelva, R., Branagan, G., Longstaff, L., Ding, D., Barlow, C., Foster, J., Edwards, J., Ward, A., Tadross, D., Majkowski, L., Blundell, C., Forlani, S., Nair, R., Guha, S., Brown, S.R., Steele, C., Kelty, C.J., Newman, T., Lee, M., Chetty, G., Lye, G., Balasubramanian, S.P., Sureshkumar Shah, N., Sherif, M., Al-mukhtar, A., Whitehall, E., Giblin, A., Sharkey, A., Adamec, A., Madan, S., Narice, B., Sterrenburg, M., Thompson, A., Varley, I., Stavrakas, M., Rominiyi, O., Ray, J., Crank, M., Bacon, A., Al-Tamimi, Y., Catto, J., Saad, S., Abd Kahar, N.N., Sou, A., Simpson, D., Hamilton, E., Blair, J., Jallad, S., Lord, J., Anderson, C., El Kafsi, J., Logishetty, K., Saadya, A., Midha, R., Ip, M., Subbiah Ponniah, H., Stockdale, T., Bacarese-Hamilton, T., Foster, L., James, A., Anjarwalla, N., Marujo Henriques, D., Hettige, R., Baban, C., Tenovici, A., Salerno, G., Lane, J., Colvin, H.V., Badran, A., Cadersa, A., Cumpstey, A., Hamady, Z., Aftab, R., Wensley, F., Byrne, J., Morrison-Jones, V., Sekhon, G.K., Shields, H., Shakoor, Z., Yener, A., Talbot, T., Alzetani, A., Cresner, R., Babu, B.H.B., Liyanage, A.S.D., Newman, S., Blake, I., Weerasinghe, C., Baumber, R., Parry, J., Menakaya, C., Webb, J.I., Antar, M., Modi, N., Sofat, R., Noel, J., Nunn, R., Adegbola, S., Eriberto, F., Sharma, V., Tanna, R., Lodhia, S., Johnson, D., Hughes, I., Hall, J., Rooney, J., Chatterji, S., Zhang, Y., Owen, R., Rudic, M., Hunt, J., Zakai, D., Aladeojebi, A., Ali, M., Gaunt, A., Barmayehvar, B., Kitchen, M., Gowda, M., Mansour, F., Jarvis, M., Halliday, E., Lefroy, R., Nanjaiah, P., Lin, D.J., Rajgor, A.D., Scurrah, R.J., Kang, C., Watson, L.J., Harris, G., Royle, T., Cunningham, Y., Steel, B., Luk, A.C.O., Boulton, A.J., Khan, T., Bakolas, G., Herrod, P., Gemmill, E., Boyd-Carson, H., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Li, Z., Parkins, K., Spencer, N., Harries, R., Egan, R.J., Motter, D., Jenvey, C., Mahoney, R., Fine, N., Minto, T., Henry, A., Hollyman, M., Grieco, C., Gemmell, C., Whitmore, H., Babar, M.S., Goodrum, S., Scott, R., Collard, B., Lau, K., Thomas, E., Patel, A., Allison, J., Bowen, J., Dias, A., Mahendran, B., Gopalswamy, S., Patil, S., Scott, L., Sarveswaran, J., Michel, M., Ravindran, S., Subba, K., Abou-Foul, A.K., Khalefa, M., Hossain, F., Moores, T., Pickering, L., Stables, G., Doorgakant, A., Thiruvasagam, V.G., Carter, J., Reid, S., Mohammed, R., Marlow, W., Ferguson, H., Wilkin, R., Konstantinou, C., Yershov, D., Vatish, J., Denning, A., Shah, H.B., Cross, G.W.V., Seyed-Safi, P., Smart, Y.W., Kuc, A., Al-Yaseen, M., Olivier, J., Hanna, M., Eskander, P., Duncan, R., Halaseh, S., Das, R., Wynn Jones, H., Divecha, H., Whelton, C., Board, T., Powell, S., Magee, C., Agarwal, K., Mangos, E., Nambirajan, T., Vidya, R., Chauhan, G., Kaur, J., Burahee, A., Bleibleh, S., Pigadas, N., Snee, D., Bhasin, S., Crichton, A., Habeebullah, A., Bodla, A.S., Yassin, N., Mondragon, M., Dewan, V., Flindall, I., Mahendran, V., Hanson, A., Jenner, E., Richards, J., Thomas-Fernandez, K., Wall, R., Alqallaf, A., Ben-Sassi, A., Mellor, K., Joshi, P., Joshi, Y., Young, R., Miu, V., Sheridan, K., MacDonald, L., Green, S., Onos, L., Wong, J.J., Napolitano, L., Hemmila, M., Amin, D., Abramowicz, S., Roser, S.M., Olson, K.A., Riley, C., Heron, C., Cardenas, T., Leede, E., Thornhill, M., Haynes, A.B., McElhinney, K., Roward, S., Trust, M.D., Hill, C.E., Teixeira, P.G., Etchill, E., Stevens, K., Ladd, M.R., Long, C., Rose, J., Kent, A., Yesantharao, P., Vervoort, D., Jenny, H., Gabre-Kidan, A., Margalit, A., Tsai, L., Malapati, H., Yesantharao, L., Abdou, H., Diaz, J., Richmond, M., Clark, J., O'Meara, L., Hanna, N., Ying, Y., Fleming, J., Ovaitt, A., Gigliotti, J., Fuson, A., Cooper, Z., Salim, A., Hirji, S.A., Chung, C., Hansen, L., Okafor, B.U., Roxo, V., Raut, C.P., Jolissaint, J.S., Mahvi, D.A., Kaafarani, H., Breen, K., Bankhead-Kendall, B., Alser, O., Mashbari, H., Velmahos, G., Maurer, L.R., El Moheb, M., Gaitanidis, A., Naar, L., Christensen, M.A., Kapoen, C., Langeveld, K., El Hechi, M., Mokhtari, A., Haqqani, M.H., Drake, F.T., Goldenberg-Sandau, A., Galbreath, B., Reinke, C., Ross, S., Thompson, K., Manning, D., Perkins, R., Eriksson, E., Evans, H., Masrur, M., Giulianotti, P., Benedetti, E., Chang, G., Ourieff, J., Dehart, D., Dorafshar, A., Price, T., Bhama, A.R., Torquati, A., Cherullo, E., Kennedy, R., Myers, J., Rubin, K., Ban, V.S., Aoun, S.G., Batjer, H.H., Caruso, J., Carmichael, H., Velopulos, C.G., Wright, F.L., Urban, S., McIntyre, R.C., Schroeppel, T.J., Hennessy, E.A., Dunn, J., Zier, L., Burlew, C., Coleman, J., Colling, K.P., Hall, B., Rice, H.E., Hwang, E.S., Olson, S.A., Moris, D., Verma, R., Hassan, R., Volpe, A., Merola, S., O'Banion, L.A., Lilienstein, J., Dirks, R., Marwan, H., Almasri, M., Kulkarni, G., Mehdi, M., Abouassi, A., Abdallah, M., San Andrés, M., Eid, J., Aigbivbalu, E., Sundaresan, J., George, B., Ssentongo, A., Ssentongo, P., Oh, J.S., Hazelton, J., Maines, J., Gusani, N., Garner, M., Horvath, S., Zheng, F., Ujiki, M., Kinnaman, G., Meagher, A., Sharma, I., Holler, E., McKenzie, K., Chan, J., Fretwell, K., Nugent, W., Khalil, A., Chen, D., Post, N., Rostkowski, T., Brahmbhatt, D., Huynh, K., Hibbard, M.L., Schellenberg, M., Martin, R.C.G., Bhutiani, N., Giorgakis, E., Laryea, J., Bhavaraju, A., Sexton, K., Kost, M., Kimbrough, M., Burdine, L., Kalkwarf, K., Robertson, R., Gosain, A., Camp, L., Lewit, R., Kronenfeld, J.P., Urrechaga, E., Goel, N., Rattan, R., Hart, V., Gilna, G., Cioci, A., Ruiz, G., Rakoczy, K., Pavlis, W., Saberi, R., Morris, R., Karam, B.S., Brathwaite, C.E.M., Liu, H., Petrone, P., Hakmi, H., Sohail, A.H., Baltazar, G., Heckburn, R., Nygaard, R.M., Colonna, E.T., Endorf, F.W., Hill, M.J., Maiga, A., Dennis, B., Levin, J.H., Lallemand, M., Choron, R., Peck, G., Soliman, F., Rehman, S., Glass, N., Juthani, B., Deisher, D., Ruzgar, N.M., Ullrich, S.J., Sion, M., Paranjape, C., Kar, A.R., Gillezeau, C., Rapp, J., Taioli, E., Miles, B.A., Alpert, N., Podolsky, D., Coleman, N.L., Callahan, M.P., Ganly, I., Brown, L., Monson, J.R.T., Dehal, A., Abbas, A., Soliman, A., Kim, B., Jones C Dauer, M.D.E., Renza-Stingone, E., Hernandez, E., Gokcen, E., Kropf, E., Sufrin, H., Hirsch, H., Ross, H., Engel, J., Sewards, J., Poggio, J., Sanserino, K., Rae, L., Philp, M., Metro, M., McNelis, P., Petrov, R., Pazionis, T., Till, B., Lamm, R., Rios-Diaz, A.J., Palazzo, F., Rosengart, M., Nicholson, K., Carrick, M.M., Rodkey, K., Suri, A., Callcut, R., Nicholson, S., Talathoti, N., Klaristenfeld, D., Biffl, W., Marsh, C., Schaffer, K., Berndtson, A.E., Averbach, S., Curry, T., Kwan-Feinberg, R., Consorti, E., Gonzalez, R., Grolman, R., Liu, T., Merzlikin, O., Abel, M.K., Ozgediz, D., Boeck, M., Kornblith, L.Z., Nunez-Garcia, B., Robinson, B., Park, P., Utria, A.F., Rice-Townsend, S.E., Javid, P., Hauptman, J., Kieran, K., Nehra, D., Walters, A., Cuschieri, J., Davidson, G.H., Nunez, J., Cosker, R., Eckhouse, S., Choudhry, A., Marx, W., Jamil, T., Seegert, S., Al-Embideen, S., Quintana, M., Jackson, H., Wexner, S.D., Kent, I., Martins, P.N., Alshehari, M., Al-Naggar, H., Alsayadi, M., Alyazidi, M., Shream, S., Alhaddad, W., Maqus, A., Abu Hamra'a, M., Alsayadi, R., Ghannam, R., Al-Maqtari, S., Masdoos, S., Al-Harazi, Y., Bajjah, H., Al-ameri, S., Aldawbali, M., Gwini, G.P., and Mazingi, D.
Subjects: Pulmonary and Respiratory Medicine, Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), complication, Article, NO, Cohort Studies, outcomes, complications, following cardiac surgery, coronavirus disease 2019, Postoperative Complications, Cardiovascular Diseases, Female, Humans, Middle Aged, SARS-CoV-2, COVID-19, Cardiac Surgical Procedures, Internal medicine, Cardiovascular Disease, medicine, Cardiac Surgical Procedure, In patient, LS7_4, business.industry, Cardiac surgery, outcome, Surgery, Cohort Studie, Cardiology and Cardiovascular Medicine, business, cardiac surgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study, Human
Abstract: The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection was associated with an overall mortality of 24% and postoperative pulmonary complications in half of all patients.3 Cardiac surgery arguably represents a higher risk population than general or orthopedic surgery due to the high American Society of Anesthesiologists grades and multiple comorbidities usually seen. We present a subgroup analysis of COVIDSurg data, including patients who underwent cardiac surgery between March 1, 2020, and July 31, 2020, across 13 countries, with a confirmed perioperative (7 days preoperative up to 30 days postoperative) diagnosis of COVID-19 infection. This is presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology statement for cohort studies.4 Categorical variables were expressed as frequency and percentages and c2 or Fisher exact test was used to compare categorical variables. Only anonymized data were collected. Patient consent was obtained unless it was waived by local research committees. In the United Kingdom, the study was registered at each site as either a clinical audit or service evaluation and consent was waived. In other countries, local investigators were responsible for contacting research ethics committees to obtain local or national approvals in line with applicable regulations.
Published: 2021
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23. Die Wirkung der Verarbeitungsflüssigkeit repetitiver Online-Produktwerbung auf die Produktbewertung

Author: Howald, Annika, Olga, Rose, Grossenbacher, Maria, Kunz, Adrian, Linder, Mirjam, and Mengestabe, Abileather
Subjects: Business, Social and Behavioral Sciences
Abstract: Dieses Forschungsprojekt untersucht den Effekt der Verarbeitungsflüssigkeit auf die Produktbewertung.
Published: 2022
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24. Die Wirkung repetitiver Online-Produktwerbung auf die Verarbeitungsflüssigkeit und die Produktbewertung

Author: Grossenbacher, Maria, Rose, Olga, Howald, Annika, Mengestabe, Abileather, Linder, Mirjam, and Kunz, Adrian
Subjects: Behavioral Economics, FOS: Psychology, Business Intelligence, Economics, Psychology, Business, Experimental Analysis of Behavior, Social and Behavioral Sciences
Abstract: BACS - Business Academic Skills / Klasse 2z / Gruppe 2 Dieses Forschungsexperiment untersucht den Effekt der Wiederholung von Produktwerbung auf die Verarbeitungsflüssigkeit und auf die Produktbewertung.
Published: 2022
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25. Die Wirkung von der repetitiven Online-Produktwerbung auf die Verarbeitungsflüssigkeit der Produktbewertung

Author: Mengestabe, Abileather, Howald, Annika, Grossenbacher, Maria, Linder, Mirjam, Kunz, Adrian, and Olga, Rose
Subjects: Marketing, FOS: Economics and business, Advertising and Promotion Management, Business
Abstract: BACS (3z): Gruppe 2 Das Forschungsprojekt untersucht die Wirkung von repetitiven Produktwerbungen auf die Verarbeitungsflüssigkeit und dessen Produktbewertung von Testpersonen.
Published: 2022
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26. Processing Fluency

Author: Linder, Mirjam, Olga, Rose, Grossenbacher, Maria, Howald, Annika, Kunz, Adrian, and Mengestabe, Abileather
Subjects: Business
Abstract: Dieses Forschungsprojekt untersucht, wie sich die Repetition von Produktewerbung auf die Produktebewertung auswirkt.
Published: 2022
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27. Quantifying Raptors’ Flight Behavior to Assess Collision Risk and Avoidance Behavior to Wind Turbines

Author: Cino Pertoldi, Anne Cathrine Linder, Dan Bruhn, Bjarke Laubek, and Henriette Lyhne
Subjects: red kite, Wind power, Physics and Astronomy (miscellaneous), business.industry, General Mathematics, flight behavior, flight symmetry, wind turbine curtailment, Avoidance response, IdentiFlight, Collision risk, Chemistry (miscellaneous), White-tailed eagle, Computer Science (miscellaneous), Environmental science, white-tailed eagle, ecology, business, avoidance response, golden eagle, Marine engineering
Abstract: Some wind farms have implemented automated camera-based monitoring systems, e.g., IdentiFlight to mitigate the impact of wind turbines on protected birds. These systems have promoted the collection of large amounts of unique data that can be used to describe flight behavior in a novel way. The aim of this study was to evaluate how this unique data can be used to create a robust quantitative behavioral analysis, that can be used to identify risk-prone flight behavior and avoidance behavior and thereby used to assess collision risk in the future. This was achieved through a case study at a wind farm on the Swedish island Gotland, where golden eagles (Aquila chrysaetos), white-tailed eagles (Haliaeetus albicilla), and red kites (Milvus milvus), were chosen as the bird species. These three species are generally rare breeds in Europe and have also been shown to be particularly vulnerable to collisions with wind turbines. The results demonstrate that data from the IdentiFlight system can be used to identify risk-prone flight behaviors, e.g., tortuous flight and foraging behavior. Moreover, it was found that these flight behaviors were affected by both weather conditions, but also their distance to the nearest wind turbine. This data can, thus, be used to evaluate collision risk and avoidance behavior. This study presents a promising framework for future research, demonstrating how data from camera-based monitoring systems can be utilized to quantitatively describe risk-prone behavior and thereby assess collision risk and avoidance behavior.
Published: 2022
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28. Effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in atrial fibrillation:a scandinavian population-based cohort study

Author: Stefan H. Hohnloser, Marie Linder, Aaron Jenkins, Faris Al-Khalili, Grethe S. Tell, Sigrun Halvorsen, Morten Madsen, Vera Ehrenstein, Søren Paaske Johnsen, Gunnar Gislason, Waleed Ghanima, and Gerhard Sulo
Subjects: Male, medicine.medical_specialty, medicine.drug_class, Population, Embolism, Hemorrhage, 030204 cardiovascular system & hematology, VALIDATION, Dabigatran, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Rivaroxaban, WORLD, Internal medicine, Atrial Fibrillation, medicine, MANAGEMENT, Humans, QUALITY, 030212 general & internal medicine, education, PATIENT REGISTRY, Stroke, Aged, education.field_of_study, business.industry, Health Policy, Bleeding, Warfarin, DABIGATRAN, RIVAROXABAN, Anticoagulants, Atrial fibrillation, Vitamin K antagonist, medicine.disease, EFFICACY, APIXABAN, Apixaban, Female, Cardiology and Cardiovascular Medicine, business, Cohort study, medicine.drug
Abstract: Aims Using Scandinavian population-based registries, we assessed risk of stroke/systemic embolism (SE) and bleeding with non-vitamin K antagonist oral anticoagulants compared with warfarin in anticoagulation-naïve patients with atrial fibrillation (AF). Methods and results This historical cohort study included 219 545 AF patients [median age 74 years; 43% women; mean CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke or transient ischaemic attack, vascular disease, age 65–74 years, sex category) score 3.3] initiating apixaban, dabigatran, rivaroxaban, or warfarin in Denmark, Norway, and Sweden (1 January 2013 to 31 December 2016). The primary endpoints were stroke/SE and major bleeding. The median follow-up times were 9.7 (3.9–21.5) months for stroke/SE and 9.6 (3.8–21.3) months for bleeding. Apixaban and warfarin initiators were older and had higher CHA2DS2-VASc scores compared with dabigatran and rivaroxaban initiators. After 1:1 propensity score matching, three cohorts were created: apixaban–warfarin (n = 111 162), dabigatran–warfarin (n = 56 856), and rivaroxaban–warfarin (n = 61 198). Adjusted hazard ratios (HRs) were estimated using a Cox regression. For stroke/SE, adjusted HRs against warfarin were 0.96 [95% confidence interval (CI): 0.87–1.06] for apixaban, 0.89 (95% CI: 0.80–1.00) for dabigatran, and 1.03 (95% CI: 0.92–1.14) for rivaroxaban. For major bleeding, the HRs against warfarin were 0.73 (95% CI: 0.67–0.78) for apixaban, 0.89 (95% CI: 0.82–0.97) for dabigatran, and 1.15 (95% CI: 1.07–1.25) for rivaroxaban. The results in the dabigatran cohort did not hold in all dose-defined subgroups. Conclusion In this large Scandinavian study among AF patients initiating oral anticoagulation, those initiating dabigatran, apixaban, and rivaroxaban had similar rates of stroke/SE to patients initiating warfarin. Rates of major bleeding were lower with apixaban and dabigatran and higher with rivaroxaban, each compared with warfarin.
Published: 2022
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29. The Role of Electronic Health Records in Advancing Genomic Medicine

Author: Jodell E. Linder, Lisa Bastarache, Jacob J. Hughey, and Josh F. Peterson
Subjects: business.industry, MEDLINE, Genomics, Computational biology, Phenome, Health records, Research findings, Phenotype, Risk Factors, Genomic technology, Genetics, Electronic Health Records, Humans, Genomic medicine, Medicine, Translational genomics, business, Molecular Biology, Genetics (clinical), Genome-Wide Association Study
Abstract: Recent advances in genomic technology and widespread adoption of electronic health records (EHRs) have accelerated the development of genomic medicine, bringing promising research findings from genome science into clinical practice. Genomic and phenomic data, accrued across large populations through biobanks linked to EHRs, have enabled the study of genetic variation at a phenome-wide scale. Through new quantitative techniques, pleiotropy can be explored with phenome-wide association studies, the occurrence of common complex diseases can be predicted using the cumulative influence of many genetic variants (polygenic risk scores), and undiagnosed Mendelian syndromes can be identified using EHR-based phenotypic signatures (phenotype risk scores). In this review, we trace the role of EHRs from the development of genome-wide analytic techniques to translational efforts to test these new interventions to the clinic. Throughout, we describe the challenges that remain when combining EHRs with genetics to improve clinical care.
Published: 2021
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30. <scp>DNase</scp> Treatment Prevents <scp>Cerebrospinal Fluid</scp> Block in Early Experimental Pneumococcal Meningitis

Author: Chiara Pavan, Anna L. R. Xavier, Marta Ramos, Jane Fisher, Marios Kritsilis, Adam Linder, Peter Bentzer, Maiken Nedergaard, and Iben Lundgaard
Subjects: Pathology, medicine.medical_specialty, medicine.drug_class, Antibiotics, Cisterna magna, Extracellular Traps, Meningitis, Bacterial, Cerebral edema, Rats, Sprague-Dawley, Cerebrospinal fluid, Parenchyma, medicine, Animals, Cerebrospinal Fluid, Deoxyribonucleases, Meningitis, Pneumococcal, business.industry, Brain, Neutrophil extracellular traps, medicine.disease, Neurology, Glymphatic system, Neurology (clinical), business, Glymphatic System, Meningitis
Abstract: Objective S. pneumoniae is the most common cause of bacterial meningitis, a disease that, despite treatment with antibiotics, still is associated with a high mortality and morbidity worldwide. Diffuse brain swelling is a leading cause of morbidity in S. pneumoniae meningitis. We hypothesized that neutrophil extracellular traps (NETs) disrupt CSF transport by the glymphatic system and contribute to edema formation in S. pneumoniae meningitis. Methods We used DNase I treatment to disrupt NETs and then assessed glymphatic function by cisterna magna injections of CSF tracers in a rat model of S. pneumoniae meningitis. Results Our analysis showed that CSF influx into the brain parenchyma, as well as CSF drainage to the cervical lymph nodes, were significantly reduced in the rat model of S. pneumoniae meningitis. Degrading neutrophil extracellular traps (NETs) by DNase treatment restored glymphatic transport and eliminated the increase in brain weight in the rats. In contrast, first-line antibiotic treatment had no such effect on restoring fluid dynamics. Interpretation This study suggests that CSF accumulation is responsible for cerebral edema formation and identifies the glymphatic system and NETs as possible new treatment targets in S. pneumoniae meningitis. This article is protected by copyright. All rights reserved.
Published: 2021
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31. Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score With Implications for the Sepsis-3 Criteria

Author: Christian Unge, Kristoffer Strålin, Logan Ward, John Karlsson Valik, Aron Henriksson, Lisa Mellhammar, Pontus Naucler, Jonas Sundén-Cullberg, Hercules Dalianis, and Adam Linder
Subjects: Male, medicine.medical_specialty, Organ Dysfunction Scores, Critical Care and Intensive Care Medicine, Cohort Studies, Sepsis, Oxygen Consumption, Internal medicine, medicine, Humans, Respiratory function, Hospital Mortality, Respiratory system, Aged, Retrospective Studies, Receiver operating characteristic, business.industry, Emergency department, Odds ratio, Middle Aged, medicine.disease, Systemic Inflammatory Response Syndrome, Oxygen, Intensive Care Units, Oxygen Saturation, Cohort, Female, business, Cohort study
Abstract: OBJECTIVES Sequential Organ Failure Assessment score is the basis of the Sepsis-3 criteria and requires arterial blood gas analysis to assess respiratory function. Peripheral oxygen saturation is a noninvasive alternative but is not included in neither Sequential Organ Failure Assessment score nor Sepsis-3. We aimed to assess the association between worst peripheral oxygen saturation during onset of suspected infection and mortality. DESIGN Cohort study of hospital admissions from a main cohort and emergency department visits from four external validation cohorts between year 2011 and 2018. Data were collected from electronic health records and prospectively by study investigators. SETTING Eight academic and community hospitals in Sweden and Canada. PATIENTS Adult patients with suspected infection episodes. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS The main cohort included 19,396 episodes (median age, 67.0 [53.0-77.0]; 9,007 [46.4%] women; 1,044 [5.4%] died). The validation cohorts included 10,586 episodes (range of median age, 61.0-76.0; women 42.1-50.2%; mortality 2.3-13.3%). Peripheral oxygen saturation levels 96-95% were not significantly associated with increased mortality in the main or pooled validation cohorts. At peripheral oxygen saturation 94%, the adjusted odds ratio of death was 1.56 (95% CI, 1.10-2.23) in the main cohort and 1.36 (95% CI, 1.00-1.85) in the pooled validation cohorts and increased gradually below this level. Respiratory assessment using peripheral oxygen saturation 94-91% and less than 91% to generate 1 and 2 Sequential Organ Failure Assessment points, respectively, improved the discrimination of the Sequential Organ Failure Assessment score from area under the receiver operating characteristics 0.75 (95% CI, 0.74-0.77) to 0.78 (95% CI, 0.77-0.80; p < 0.001). Peripheral oxygen saturation/FIO2 ratio had slightly better predictive performance compared with peripheral oxygen saturation alone, but the clinical impact was minor. CONCLUSIONS These findings provide evidence for assessing respiratory function with peripheral oxygen saturation in the Sequential Organ Failure Assessment score and the Sepsis-3 criteria. Our data support using peripheral oxygen saturation thresholds 94% and 90% to get 1 and 2 Sequential Organ Failure Assessment respiratory points, respectively. This has important implications primarily for emergency practice, rapid response teams, surveillance, research, and resource-limited settings.
Published: 2021
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32. Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease‐specific treatments: a French nationwide cohort study

Author: Agnès Sommet, Margaux Lafaurie, Mette Nørgaard, Charlotta Ekstrand, Bérangère Baricault, Shahram Bahmanyar, Julien Maquet, Christian Fynbo Christiansen, Maryse Lapeyre-Mestre, Marie Linder, Laurent Sailler, and Guillaume Moulis
Subjects: Male, pharmacoepidemiology, medicine.medical_treatment, Comorbidity, corticosteroids, Adrenal Cortex Hormones, Risk Factors, intravenous immunoglobulin, hemic and lymphatic diseases, education.field_of_study, Hazard ratio, Age Factors, Immunoglobulins, Intravenous, Hematology, Middle Aged, Combined Modality Therapy, Hospitalization, Venous thrombosis, immune thrombocytopenia, Cardiovascular Diseases, Cohort, Splenectomy, Female, France, Receptors, Thrombopoietin, Cohort study, Adult, medicine.medical_specialty, Adolescent, Population, splenectomy, Young Adult, Sex Factors, Internal medicine, medicine, Humans, education, thrombosis, Aged, Proportional Hazards Models, Purpura, Thrombocytopenic, Idiopathic, Proportional hazards model, business.industry, Thrombosis, medicine.disease, Thrombocytopenia, Confidence interval, thrombopoietin-receptor agonists, Anemia, Hemolytic, Autoimmune, business
Abstract: We aimed to assess the risk factors of venous thrombosis (VT) and arterial thrombosis (AT) in adults with primary immune thrombocytopenia (ITP), particularly in relation to treatments. The population comprised all incident primary ITP adults in France between 2009 and 2017 (FAITH cohort; NCT03429660) built in the national health database. Outcomes were the first hospitalisation for VT and AT. Multivariable Cox regression models included baseline risk factors, time-varying exposure to ITP drugs, splenectomy and to cardiovascular drugs. The cohort included 10 039 patients. A higher risk of hospitalisation for VT was observed with older age, history of VT, history of cancer, splenectomy [hazard ratio (HR) 3·23, 95% confidence interval (CI) 2·26-4·61], exposure to corticosteroids (HR 3·55, 95% CI 2·74-4·58), thrombopoietin-receptor agonists (TPO-RAs; HR 2·28, 95% CI 1·59-3·26) and intravenous immunoglobulin (IVIg; HR 2·10, 95% CI 1·43-3·06). A higher risk of hospitalisation for AT was observed with older age, male sex, a history of cardiovascular disease, splenectomy (HR 1·50, 95% CI 1·12-2·03), exposure to IVIg (HR 1·85, 95% CI 1·36-2·52) and TPO-RAs (HR 1·64, 95% CI 1·26-2·13). Rituximab was not associated with an increased risk. These findings help to estimate the risk of thrombosis in adult patients with ITP and to select treatment.
Published: 2021
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33. Transcatheter aortic valve implantation in patients with a small aortic annulus: performance of supra-, intra- and infra-annular transcatheter heart valves

Author: Matthias Renker, Lisa Voigtländer, Won-Keun Kim, Tobias Schmidt, Niklas Schofer, M. Linder, Hermann Reichenspurner, Matti Adam, Georg Nickenig, Dirk Westermann, Victor Mauri, Atsushi Sugiura, Lenard Conradi, Alina Goßling, Jan-Malte Sinning, Moritz Seiffert, Stefan Blankenberg, and Christian W. Hamm
Subjects: Male, medicine.medical_specialty, Transcatheter aortic, Hemodynamics, Regurgitation (circulation), Prosthesis Design, Transcatheter Aortic Valve Replacement, Internal medicine, Multidetector Computed Tomography, medicine, Humans, In patient, Heart valve, Cardiac skeleton, Aged, Retrospective Studies, Annulus (mycology), Aged, 80 and over, Original Paper, Transcatheter aortic valve implantation, business.industry, Aortic stenosis, Calcinosis, General Medicine, Aortic Valve Stenosis, Small aortic annulus, medicine.anatomical_structure, Increased risk, Treatment Outcome, Aortic Valve, Fluoroscopy, Heart Valve Prosthesis, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Background A small aortic annulus is associated with increased risk of prosthesis–patient mismatch (PPM) after transcatheter aortic valve implantation (TAVI). Whether specific transcatheter heart valve (THV) designs yield superior hemodynamic performance in these small anatomies remains unclear. Methods Data from 8411 consecutive patients treated with TAVI from May 2012 to April 2019 at four German centers were retrospectively evaluated. A small aortic annulus was defined as multidetector computed tomography-derived annulus area 2. TAVI was performed with a balloon-expanding intra-annular (Sapien-3, n = 288), self-expanding intra-annular (Portico, n = 110), self-expanding supra-annular (Evolut, n = 179 and Acurate-Neo, n = 428) and mechanically expanding infra-annular (Lotus, n = 64) THV according to local practice. PPM was defined as indexed effective orifice area ≤ 0.85cm2/m2. Results A small annulus was found in 1069 (12.7%) patients. PPM was detected in 38.3% overall with a higher prevalence after implantation of a balloon-expanding intra-annular or mechanically expanding infra-annular THV compared to self-expanding intra- and supra-annular THV. Multivariable analysis linked self-expanding THV (Evolut: Odds ratio [OR] 0.341, Acurate-Neo: OR 0.436, Portico: OR 0.291), postdilatation (OR 0.648) and age (OR 0.968) to lower rates of PPM, while aortic valve calcification was associated with an increased risk (OR 1.001). Paravalvular regurgitation > mild was more frequent after TAVI with self-expanding THV (p = 0.04). Conclusion In this large contemporary multicenter patient population, a substantial number of patients with a small aortic anatomy were left with PPM after TAVI. Self-expanding supra- and intra-annular THV demonstrated superior hemodynamics in these patients at risk, however at the cost of higher rates of residual paravalvular regurgitation. Graphic abstract
Published: 2021

34. Current and future challenges in quality assurance in molecular diagnostics

Author: Mark W. Linder, Katarina Baluchova, Deborah A. Payne, Aldo Vacaflores Salinas, Parviz Ahmad-Nejad, Jim F. Huggett, Werner Steimer, Tester F. Ashavaid, and Kathryn A. Harris
Subjects: Quality Control, 0301 basic medicine, Quality management, Quality Assurance, Health Care, Computer science, media_common.quotation_subject, Clinical Biochemistry, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Humans, Quality (business), Pathology, Molecular, media_common, business.industry, Test procedures, Biochemistry (medical), General Medicine, Guideline, Molecular diagnostics, 030104 developmental biology, Risk analysis (engineering), 030220 oncology & carcinogenesis, Laboratories, business, Quality assurance
Abstract: The development and performance of molecular genetic assays has required increasingly complex quality assurance in recent years and continues to pose new challenges. Quality management officers, as well as academic and technical personnel are confronted with new molecular genetic parameters, methods, changing regulatory environments, questions regarding appropriate validation, and quality control for these innovative assays that are increasingly applying quantification and/or multiplex formats. Yet, quality assurance and quality control guidelines are still not widely available or in some circumstances have become outdated. For these reasons, the need for solutions to provide test confidence continues to grow. In order to integrate new test procedures into existing quality assurance measures, the ISO 15189 guideline can serve as an orientation. The ISO 15189 guideline describes requirements for medical laboratories and thus includes those performing molecular diagnostics. This article gives an overview of the possibilities and challenges in quality assurance of molecular parameters and shows possible solutions.
Published: 2021
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35. Urinary Symptoms and Bladder Voiding Dysfunction Are Common in Young Men with Defecatory Disorders: A Retrospective Evaluation

Author: Brian J. Linder, David O. Prichard, Lawrence A. Szarka, and Bradley A White
Subjects: medicine.medical_specialty, Pelvic floor, Constipation, Physiology, business.industry, Anorectal manometry, Urinary bladder neck obstruction, Gastroenterology, Odds ratio, medicine.disease, Frequent urination, medicine.anatomical_structure, Lower urinary tract symptoms, Internal medicine, medicine, medicine.symptom, Prospective cohort study, business
Abstract: Lower urinary tract symptoms (LUTS) are frequently reported by constipated patients. Prospective studies investigating the association between defecatory disorders (DDs) and voiding dysfunction, predominantly in women, have reported conflicting results. This study investigated (1) the prevalence of LUTS in young men with DDs and (2) the association between objectively documented DDs and voiding dysfunction in constipated young men with LUTS. We reviewed the medical records, including validated questionnaires, of men aged 18–40 with confirmed DDs treated with pelvic floor physical therapy (PT) at our institution from May 2018 to November 2020. In a separate group of constipated young men with LUTS who underwent high-resolution anorectal manometry (HRM), rectal balloon expulsion test (BET), and uroflowmetry, we explored the relationship between DDs and voiding dysfunction. A total of 72 men were evaluated in the study. Among 43 men receiving PT for a proven DD, 82% reported ≥ 1 LUTS, most commonly frequent urination. Over half of these men experienced a reduction in LUTS severity after bowel-directed pelvic floor PT. Among 29 constipated men with LUTS who had undergone HRM/BET and uroflowmetry, 28% had concurrent defecatory and voiding dysfunction, 10% had DD alone, 14% had only voiding dysfunction, and 48% had neither. The presence of DD was associated with significantly increased odds of concurrent voiding dysfunction (odds ratio 9.3 [95% CI 1.7–52.7]). Most young men with DDs experience LUTS, which may respond to bowel-directed physical therapy. Patients with DD and urinary symptoms have increased odds of voiding dysfunction.
Published: 2021
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36. Characteristics of laparoscopic and open hernia repair simulation models: a systematic review

Author: J. Vance-Daniel, C. Linder, and T. Pelly
Subjects: medicine.medical_specialty, Hernia, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Hernia, Inguinal, Review, Education, Synthetic materials, law.invention, Randomized controlled trial, law, medicine, Animals, Humans, Medical physics, Simulation Training, Herniorrhaphy, business.industry, Construct validity, medicine.disease, Hernia repair, Surgery, Inguinal hernia, Learning curve, Laparoscopy, business, Simulation
Abstract: Purpose Barriers to education in open and laparoscopic hernia repair technique include a steep learning curve and reduced theatre time for junior surgical trainees. This is particularly evident during the current COVID-19 pandemic. Simulation models may provide further opportunities for training in hernia repair outside of the traditional surgical apprenticeship model. Methods A systematic review was carried out following PRISMA guidelines to identify and evaluate simulation models in hernia repair. Of the 866 records screened, 27 were included in the analysis. These were assessed for face, content and construct validity, as well as their attempt to measure educational impact. Results Simulation models were identified comprising of animal tissues, synthetic materials and virtual reality (VR) technology. Models were designed for instruction in repair of inguinal, umbilical, incisional and diaphragmatic hernias. Twenty-one laparoscopic hernia repair models were described. Many models demonstrated validity across several domains, and three showed transferability of skills from simulation to the operating room. Of the six open hernia repair simulation models, none were found to have demonstrated an educational impact in addition to assessing validity. Conclusion Few models individually were able to demonstrate validity and educational impact. Several novel assessment tools have been developed for assessment of progress when performing simulated and real laparoscopic inguinal hernia repair. More study is required, particularly for open hernia repair, including randomized controlled trials with large sample sizes to assess the transferability of skills.
Published: 2021
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37. Uncertainty in the 'New Normal': Understanding the Role of Climate Change Beliefs and Risk Perceptions in Michigan Tree Fruit Growers’ Adaptation Behaviors

Author: Julia Linder and Victoria Campbell-Arvai
Subjects: Atmospheric Science, Global and Planetary Change, business.industry, media_common.quotation_subject, Environmental resource management, Climate change, Tree (data structure), New normal, Geography, Perception, Adaptation (computer science), business, Social Sciences (miscellaneous), media_common
Abstract: In the midwestern United States, intensifying impacts from climate change necessitate adaptation by the agricultural sector. Tree fruit agriculture is uniquely vulnerable to climate change due to the long-lived nature of perennial systems, yet very few studies have addressed how fruit growers perceive climate change and are responding to climate risks. For this study, 16 semistructured interviews were conducted with Michigan tree fruit growers to understand how their climate change beliefs, beliefs about adaptive actions, and climate-related risk perceptions influence adaptation behaviors. While there was a great deal of uncertainty about the anthropogenic nature of climate change, growers generally agreed that unprecedented changes in climate and weather patterns were occurring. Because of a perception of little control over future climate impacts, most growers reactively adapted to climate risks that negatively impacted their orchards by implementing measures such as frost protection, irrigation, pesticides, and crop insurance. This study highlighted that while proactive adaptations such as crop diversification, planting new varieties, and improving soil health will be necessary to increase farm resilience in the future, growers were unable to justify making these changes due to their uncertainty about future climate changes. The findings from this study highlight the need for future outreach efforts by university extension agents, private agricultural advisors, and federal and state agency advisors to provide educational information on the long-term impacts of climate change in order to help growers increase the resilience of their farm in the face of future climate impacts.
Published: 2021
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38. Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation

Author: Johannes Kluwe, Stefan Blankenberg, Lisa Voigtländer, Moritz Seiffert, M. Linder, Hermann Reichenspurner, Lenard Conradi, Sebastian Ludwig, Niklas Schofer, Dirk Westermann, Alina Goßling, Andreas Drolz, Lara Waldschmidt, and Paula Heimburg
Subjects: Male, Gastrointestinal bleeding, medicine.medical_specialty, Transcatheter aortic, 030204 cardiovascular system & hematology, Angiodysplasia, TAVI, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Germany, Prevalence, Medicine, Humans, In patient, 030212 general & internal medicine, Aged, Retrospective Studies, Heyde syndrome, Aged, 80 and over, Original Paper, business.industry, General Medicine, Aortic Valve Stenosis, Syndrome, medicine.disease, Surgery, Stenosis, Treatment Outcome, Paravalvular leakage, Aortic Valve, Fluoroscopy, Cardiology, Recurrent bleeding, Female, Cardiology and Cardiovascular Medicine, business, Index hospitalization, Gastrointestinal Hemorrhage, Follow-Up Studies
Abstract: Background Heyde syndrome (HS) is known as the association of severe aortic stenosis (AS) and recurrent gastrointestinal bleeding (GIB) from angiodysplasia. Data on the prevalence of HS and results after TAVI remain scarce. Methods 2548 consecutive patients who underwent TAVI for the treatment of AS from 2008 to 2017 were evaluated for a history of GIB and the presence of HS. The diagnosis of HS was defined as a clinical triad of severe AS, a history of recurrent GIB, and an endoscopic diagnosis of angiodysplasia. These patients (Heyde) were followed to investigate clinical outcomes, bleeding complications and the recurrence of GIB and were compared to patients with GIB unrelated to HS (Non-Heyde). Results A history of GIB prior to TAVI was detected in 190 patients (7.5%). Among them, 47 patients were diagnosed with HS (1.8%). Heyde patients required blood transfusions more frequently compared to Non-Heyde patients during index hospitalization (50.0% vs. 31.9%, p = 0.03). Recurrent GIB was detected in 39.8% of Heyde compared to 21.2% of Non-Heyde patients one year after TAVI (p = 0.03). In patients diagnosed with HS and recurrent GIB after TAVI, the rate of residual ≥ mild paravalvular leakage (PVL) was higher compared to those without recurrent bleeding (73.3% vs. 38.1%, p = 0.05). Conclusion A relevant number of patients undergoing TAVI were diagnosed with HS. Recurrent GIB was detected in a significant number of Heyde patients during follow-up. A possible association with residual PVL requires further investigation to improve treatment options and outcomes in patients with HS. Graphic abstract
Published: 2021

39. Product Labels for the Circular Economy: Are Customers Willing to Pay for Circular?

Author: Robert H. W. Boyer, Marcus Linder, Shiva Habibi, Agnieszka D. Hunka, and Katherine Whalen
Subjects: Environmental Engineering, Renewable Energy, Sustainability and the Environment, 020209 energy, Circular economy, 02 engineering and technology, 010501 environmental sciences, Reuse, Survey experiment, Product type, 01 natural sciences, Industrial and Manufacturing Engineering, Conjoint analysis, Product (business), Work (electrical), Willingness to pay, 0202 electrical engineering, electronic engineering, information engineering, Environmental Chemistry, Business, Marketing, 0105 earth and related environmental sciences
Abstract: While existing research has probed consumer responses to products of different recirculation pathways (recycling, reuse, refurbishment, etc), little work has examined consumer responses to an explicit “circular economy” product label or how willingness to pay is influenced by a continuum of circularity levels. This paper reports on the results of an online survey experiment that tests whether customers are willing to pay more for products with a theoretical multi-level Circular Economy score. Conjoint analysis was used on 800 respondents in the United Kingdom to test their willingness to pay for mobile phones and robot vacuum cleaners at different levels of circularity alongside other product attribute combinations. Results indicate that the average customer almost always prefers a more “circular” product when compared to products with otherwise identical attributes, and that customers are consistently willing to pay more for products with low or moderate levels of circular content. However, analysis suggests that willingness to pay more for products disappears, and in some cases declines, as the proportion of recirculated content increases. Results offer evidence that applying a numerical circular economy label at low levels of recirculated content could be a profitable strategy for producers of mobile phones and robot vacuum cleaners. Such a strategy is less certain for heavily refurbished products, fully reused products, or other product types.
Published: 2021
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40. HLA <scp>‐G</scp> expression correlates with histological grade but not with prognosis in colorectal carcinoma

Author: Hannu Sariola, Satu Wedenoja, Juha Kere, Nina Linder, Johan Lundin, Caj Haglund, Tuomas Kaprio, Department of Surgery, Clinicum, CAN-PRO - Translational Cancer Medicine Program, University of Helsinki, Helsinki University Hospital Area, Faculty of Medicine, Helsinki One Health (HOH), HUSLAB, Hannu Sariola / Principal Investigator, Department of Biochemistry and Developmental Biology, Medicum, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Johan Edvard Lundin / Principal Investigator, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator, Research Programs Unit, HUS Abdominal Center, II kirurgian klinikka, HUS Gynecology and Obstetrics, and Department of Obstetrics and Gynecology
Subjects: HLA CLASS-I, Colorectal cancer, Immunology, Human leukocyte antigen, Immune tolerance, 03 medical and health sciences, 0302 clinical medicine, HLA-G, Genetics, medicine, Humans, Immunology and Allergy, Pathological, Alleles, HLA-G Antigens, Tissue microarray, biology, business.industry, Histology, Prognosis, PREDICTIVE-VALUE, medicine.disease, CANCER, Trophoblasts, 3. Good health, MARKER, 030220 oncology & carcinogenesis, Cancer research, biology.protein, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine, Antibody, Colorectal Neoplasms, business, 030215 immunology
Abstract: Trophoblast-specific expression of human leukocyte antigen G (HLA-G) induces immune tolerance for the developing fetus. Pathological HLA-G expression later in life might contribute to immune escape of various cancers. We studied the still controversial role of HLA-G in colorectal carcinoma (CRC) using the MEM-G/1 antibody and a tissue microarray series of CRC tumors (n=317). HLA-G expression appeared in 20% of the tumors and showed high intratumoral heterogeneity. HLA-G positivity was associated with better differentiation (p=0.002) and non-mucinous histology (p=0.008). However, HLA-G expression alone showed no prognostic value: 5-years disease-specific survival among patients with HLA-G expression was 68.9% (95% CI: 62.7-75.0%) compared to 74.8% (95% CI: 63.2-86.3%) among those without expression. These results support a modulatory role of HLA-G in CRC. This article is protected by copyright. All rights reserved.
Published: 2021
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41. Prevention of coronary obstruction in patients at risk undergoing transcatheter aortic valve implantation: the Hamburg BASILICA experience

Author: Hermann Reichenspurner, Niklas Schofer, Andreas T. Schaefer, Dirk Westermann, Lenard Conradi, Daniel Kalbacher, Sebastian Ludwig, Lisa Voigtländer, M. Linder, Till Demal, Moritz Seiffert, Stefan Blankenberg, Johannes Schirmer, Adam B Greenbaum, Simon Pecha, Oliver D. Bhadra, Lara Waldschmidt, Clemens Spink, and Julius Nikorowitsch
Subjects: Aortic valve, Original Paper, Transcatheter aortic valve implantation, medicine.medical_specialty, Transcatheter aortic, business.industry, BASILICA, General Medicine, Individual risk, Euroscore ii, medicine.anatomical_structure, Internal medicine, Cohort, medicine, Cardiology, In patient, Coronary obstruction, Cardiology and Cardiovascular Medicine, business, Right coronary cusp, Artery
Abstract: Objectives This study aimed to assess the clinical outcome of the bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary obstruction (BASILICA) technique in a single-center patient cohort considered at high or prohibitive risk of transcatheter aortic valve implantation (TAVI)-induced coronary obstruction. Methods Between October 2019 and January 2021, a total of 15 consecutive patients (age 81.0 [78.1, 84.4] years; 53.3% female; EuroSCORE II 10.6 [6.3, 14.8] %) underwent BASILICA procedure prior to TAVI at our institution. Indications for TAVI were degeneration of stented (n = 12, 80.0%) or stentless (n = 1, 6.7%) bioprosthetic aortic valves, or calcific stenosis of native aortic valves (n = 2, 13.3%), respectively. Individual risk of TAVI-induced coronary obstruction was assessed by pre-procedural computed tomography analysis. Procedural and 30-day outcomes were documented in accordance with Valve Academic Research Consortium (VARC)-2 criteria. Results BASILICA was attempted for single left coronary cusp in 12 patients (80.0%), for single right coronary cusp in 2 patients (13.3%), and for both cusps in 1 patient (6.7%), respectively. The procedure was feasible in 13 patients (86.7%) resulting in effective prevention of coronary obstruction, whilst TAVI was performed without prior successful bioprosthetic leaflet laceration in two patients (13.3%). In one of these patients (6.7%), additional chimney stenting immediately after TAVI was performed. No all-cause deaths or strokes were documented after 30 days. Conclusion The BASILICA technique appears to be a feasible, safe and effective concept to avoid iatrogenic coronary artery obstruction during TAVI in both native and bioprosthetic valves of patients at high or prohibitive risk. ClinicalTrials.gov Identifier: NCT04227002 (Hamburg AoRtic Valve cOhoRt).
Published: 2021
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42. COVID-19-Associated Pulmonary Aspergillosis at an Academic Medical Center in the Midwestern United States

Author: Anastasia Wasylyshyn, G Rostyslaw Wasylyshyn, Marisa H. Miceli, and Kathleen A Linder
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Veterinary (miscellaneous), 030106 microbiology, Applied Microbiology and Biotechnology, Microbiology, Midwestern United States, law.invention, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, High morbidity, Galactomannan, chemistry.chemical_compound, 0302 clinical medicine, law, Internal medicine, Epidemiology, medicine, Humans, Aspergillosis, Aged, Retrospective Studies, Aged, 80 and over, Academic Medical Centers, medicine.diagnostic_test, business.industry, COVID-19, CAPA, Pneumonia, Middle Aged, Tracheal aspirate, Intensive care unit, Intensive Care Units, Pulmonary aspergillosis, Bronchoalveolar lavage, chemistry, Female, Original Article, Pulmonary Aspergillosis, business, Agronomy and Crop Science
Abstract: Pulmonary aspergillosis has been reported at high rates in patients with coronavirus disease 2019 (COVID-19) and is associated with high morbidity and mortality. We retrospectively assessed all patients admitted to an intensive care unit during the early COVID-19 surge (3/17/20–5/10/20) at our medical center in the midwestern USA for the presence of COVID-19-associated pulmonary aspergillosis (CAPA). Patients were not routinely screened for CAPA; diagnostic work-up for fungal infections was pursued when clinically indicated. Among 256 patients admitted to the ICU with severe COVID-19, 188 (73%) were intubated and 62 (24%) ultimately expired within 30 days of admission to the ICU. Only three patients (1%) were found to have CAPA; diagnosis was made by tracheal aspirate cultures in two cases and by bronchoalveolar lavage fluid Aspergillus galactomannan in one case. None of the patients who developed CAPA had classic risk factors for invasive fungal infection. The occurrence of CAPA was much lower than that reported at other centers, likely reflecting the local epidemiology.
Published: 2021
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43. Measures to reduce red cell use in patients with sickle cell disease requiring red cell exchange during a blood shortage

Author: Deborah A. Sesok-Pizzini, Stephan Kadauke, Hyun Hyung An, Stella T. Chou, Grace Linder, Haewon C. Kim, David F. Friedman, and Stacey Uter
Subjects: medicine.medical_specialty, Anemia, Cell, Economic shortage, Disease, Anemia, Sickle Cell, 030204 cardiovascular system & hematology, Hematocrit, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Pandemics, medicine.diagnostic_test, Red Cell, business.industry, Transfusion Medicine, SARS-CoV-2, COVID-19, Hematology, medicine.disease, Sickle cell anemia, medicine.anatomical_structure, Emergency medicine, Erythropoiesis, business, Erythrocyte Transfusion, 030215 immunology
Abstract: Key Points Availability of pretransfusion HbS% values before red cell exchange facilitates calculation of precise donor unit numbers required. Raising the red cell exchange end hematocrit can reduce red cell units required as a short-term measure to conserve blood in a shortage., The COVID-19 pandemic has created major disruptions in health care delivery, including a severe blood shortage. The inventory of Rh and K antigen–negative red cell units recommended for patients with hemoglobinopathies became alarmingly low and continues to be strained. Because patients with sickle cell disease requiring chronic red cell exchange (RCE) incur a large demand for red cell units, we hypothesized that implementation of 2 measures could reduce blood use. First, obtaining the pretransfusion hemoglobin S (HbS) results by procedure start time would facilitate calculation of exact red cell volume needed to achieve the desired post-RCE HbS. Second, as a short-term conservation method, we identified patients for whom increasing the targeted end procedure hematocrit up to 5 percentage points higher than the pretransfusion level (no higher than 36%) was not medically contraindicated. The goal was to enhance suppression of endogenous erythropoiesis and thereby reduce the red cell unit number needed to maintain the same target HbS%. These 2 measures resulted in an 18% reduction of red cell units transfused to 50 patients undergoing chronic RCE during the first 6 months of the COVID-19 pandemic. Despite reduction of blood use, pretransfusion HbS% target goals were maintained and net iron accumulation was low. Both strategies can help alleviate a shortage of Rh and K antigen–negative red cells, and, more generally, transfusing red cell units based on precise red cell volume required can optimize patient care and judicious use of blood resources., Visual Abstract
Published: 2021

44. Societal impact for patients with psoriasis: A nationwide Swedish register study

Author: E Christina M Wennerström, David Hägg, Marie Linder, Henrike Häbel, Björn Wettermark, and Reginald Villacorta
Subjects: medicine.medical_specialty, business.industry, NPR, National Patient Register, psoriasis, societal impact, medicine.disease, Comorbidity, ICD, International Classification of Diseases, disease burden, TPR, Total Population Register, Quality of life (healthcare), Psoriasis, Family medicine, Health care, medicine, Marital status, Original Article, PDR, Swedish Prescribed Drug Register, drug utilization, business, SEK, Swedish crowns, Socioeconomic status, Disease burden, Cohort study
Abstract: Background Psoriasis is an immune-mediated chronic inflammatory disease having a significant negative health impact. Psoriasis has societal impact; loss of productivity has been estimated at approximately 10% and it may influence the patient's financial status. Relationships between quality of life, disease severity, and cost of care need exploration. Understanding the disease burden is important for health policy and research allocation. Few studies address the research gaps in socioeconomics, comorbidity, and medication use. Objective Observing differences in education, income, employment status, marital status, health care consumption, and drug utilization between patients with psoriasis and matched controls. Methods Cohort study following socioeconomics and health care consumption for all psoriasis patients from the Swedish patient register. All individuals with a first diagnosis of psoriasis in outpatient or inpatient care from 2002 to 2013 were followed until death, emigration, or end of the study. Results Overall, 109,803 patients were included (mean age 51.2 years, 53% women) and matched with 1.08 million controls. The levels of education and income were similar, but the proportion employed was significantly lower for patients with psoriasis. There was a tendency for fewer patients with psoriasis to be married. Limitations Generalizability, lack of primary care diagnoses, and lack of early treatments (available from 2005). Conclusion Understanding of the socioeconomic impact of psoriasis is extended by showing reductions in employment.
Published: 2021
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45. Examining the Contribution of Dog Walking to Total Daily Physical Activity Among Dogs and Their Owners

Author: Laura B. Balzer, Greg J. Petrucci, Deborah E. Linder, Katie Potter, Robert T. Marcotte, and Caitlin Rajala
Subjects: medicine.medical_specialty, 030505 public health, 040301 veterinary sciences, business.industry, Physical activity, 04 agricultural and veterinary sciences, 0403 veterinary science, 03 medical and health sciences, Physical medicine and rehabilitation, Dog walking, Medicine, 0305 other medical science, business, human activities, health care economics and organizations
Abstract: Given high rates of obesity and chronic disease in both people and dogs, it is important to understand how dogs and dog owners influence each other’s health, including physical activity (PA) levels. Research suggests that dog owners who walk their dogs are more likely to meet PA guidelines than those who do not, but few studies have investigated dog walking intensity or its contribution to dog owners’ total moderate-to-vigorous PA using accelerometry. Furthermore, no studies have examined the contribution of dog walking to dogs’ total PA or the relationship between dog and dog owner PA using accelerometers on dogs. The authors used accelerometers on 33 dog owner–dog pairs to investigate (a) the intensity of dog walking behavior, (b) the contribution of dog walking to dog owners’ overall moderate-to-vigorous PA and dogs’ overall PA, and (c) the correlation between dog and dog owner PA. Dog owners wore an ActiGraph accelerometer and logged all dog walking for 7 days; dogs wore a Fitbark activity monitor. On average, 64.1% (95% confidence interval [55.2, 73.1]) of daily dog walking was moderate to vigorous intensity, and dog walking accounted for 51.2% (95% confidence interval [44.1, 58.3]) of dog owners’ daily moderate-to-vigorous PA. Dog walking accounted for 41.2% (95% confidence interval [36.0, 46.4]) of dogs’ daily PA. Dog owners’ daily steps were moderately correlated (r = .54) with dogs’ daily activity points. These findings demonstrate the interdependence of dog and dog owner PA and can inform interventions that leverage the dog–owner bond to promote PA and health in both species.
Published: 2021
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46. Management of advanced prolapse including a bowel obstruction: expanding the role of transvaginal surgery

Author: Brian J. Linder, Scott R. Kelley, and Cassandra K. Kisby
Subjects: medicine.medical_specialty, Small bowel resection, Bladder cancer, business.industry, Urology, medicine.medical_treatment, digestive, oral, and skin physiology, Obstetrics and Gynecology, medicine.disease, digestive system diseases, Colorectal surgery, Surgery, Cystectomy, Bowel obstruction, Transvaginal surgery, Concomitant, Colpocleisis, medicine, business
Abstract: Introduction and hypothesis We reviewed a case of concomitant advanced pelvic organ prolapse and partial small bowel obstruction managed via transvaginal small bowel resection and native tissue prolapse repair. Methods The patient is an 82-year-old woman with a history of a radical cystectomy and ileal conduit 2 years prior for bladder cancer that was transferred from an outside hospital for incarcerated prolapse including a small bowel obstruction with transition point inside the prolapse. She had previously unsuccessfully tried several pessaries for her prolapse. She was widowed and not sexually active. After conservative management of her bowel obstruction was unsuccessful, she was taken to the operating room for transvaginal prolapse repair. Intraoperatively, we encountered an isolated area of indurated bowel adherent to the prolapse. Colorectal surgery performed a transvaginal small bowel resection with stapled anastomosis, and a modified LeFort colpocleisis was performed to address her prolapse. Her postoperative course was uncomplicated, and at 6 months, she reported normal bowel function and had no evidence of prolapse recurrence. Conclusion We present a case of incidental bowel pathology during vaginal prolapse surgery, requiring a small bowel resection. This case demonstrates the feasibility of this procedure when working with a multi-disciplinary team and localized bowel pathology.
Published: 2021
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47. Myelodysplastic syndrome and immunotherapy novel to next in-line treatments

Author: Katherine Linder and Premal Lulla
Subjects: Oncology, medicine.medical_specialty, Myeloid, medicine.medical_treatment, Immunology, Review, Refractory, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Immunologic Factors, Immunology and Allergy, Pharmacology, business.industry, Myelodysplastic syndromes, Hematopoietic Stem Cell Transplantation, Cancer, Immunotherapy, medicine.disease, Vaccine therapy, Clinical trial, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Hypomethylating agent, Myelodysplastic Syndromes, business
Abstract: Patients with Myelodysplastic syndromes (MDS) have few therapy options for sustainable responses in the frontline setting, and even less after hypomethylating agent (HMA) failure in relapsed and refractory setting. The only potential cure is an allogeneic hematopoietic stem cell transplant which is an unrealistic option for the majority of MDS patients. Immunotherapy with checkpoint inhibition, CAR-T cells, and vaccine therapy few have shown promise in a variety cancer and have now been tested in patients with MDS. Most trials have focused on AML patients and included small numbers of MDS patients. Until now, a dedicated review of immunotherapy outcomes in MDS patients has been lacking. Thus, herein we review outcomes of MDS patients after immunotherapies on a variety of clinical trials reported to date.
Published: 2021
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48. Effect of Aerobic Exercise on Cardiopulmonary Responses and Predictors of Change in Individuals With Parkinson's Disease

Author: Susan M Linder, Nicole M. Zimmerman, Michael H. Crawford, Amanda L. Penko, and Jay L. Alberts
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Parkinson's disease, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Internal medicine, Humans, Medicine, Aerobic exercise, Single-Blind Method, Graded exercise test, Exercise, Aerobic capacity, Aged, Vital Signs, business.industry, Rehabilitation, Parkinson Disease, Middle Aged, Stepwise regression, medicine.disease, Spirometry, Cohort, Exercise Test, Cardiology, Female, Forced exercise, 0305 other medical science, business, Cadence, 030217 neurology & neurosurgery
Abstract: Objective To determine the effect of aerobic exercise on maximal and submaximal cardiopulmonary responses and predictors of change in individuals with Parkinson's disease (PD). Design Single-center, parallel-group, rater-blind study. Setting Research laboratory. Participants Individuals with mild to moderate PD (N=100). Intervention Participants were enrolled in a trial evaluating the effect of cycling on PD and randomized to either voluntary exercise (VE), forced exercise (FE), or a no exercise control group. The exercise groups were time and intensity matched and exercised 3×/wk for 8 weeks on a stationary cycle. Main Outcome Measures Cardiopulmonary responses were collected via gas analysis during a maximal graded exercise test at baseline and post intervention. Results Exercise attendance was 97% and 93% for the FE and VE group, respectively. Average exercise heart rate reserve was 67%±11% for FE and 70%±10% for VE. No significant difference was present for change in peak oxygen consumption (VO2peak) post intervention, even though the FE group had a 5% increase in VO2peak. Both the FE and VE groups had significantly higher percentage oxygen consumption per unit time ( V ˙ o 2) at ventilator threshold (VT) than the control group compared with baseline values (P=.04). Mean V ˙ O 2 at VT was 5% (95% CI, 0.1%-11%) higher in the FE group (P=.04) and 7% (2%, 12%) higher in VE group compared with controls. A stepwise linear regression model revealed that lower age, higher exercise cadence, and lower baseline VO2peak were most predictive of improved VO2peak. The overall model was found to be significant (P Conclusions Peak and submaximal cardiopulmonary function may improve after aerobic exercise in individuals with PD. Lower age, higher exercise cadence, and lower baseline VO2peak were most predictive of improved VO2peak in this exercise cohort. The improvements observed in aerobic capacity were gained after a relatively short aerobic cycling intervention.
Published: 2021
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49. Examining primary care physician rationale for not following geriatric choosing wisely recommendations

Author: Theresa A. Rowe, Tiffany Brown, Stephen D. Persell, Jeffrey A. Linder, and Jason N. Doctor
Subjects: Male, medicine.medical_specialty, Medicine (General), 01 natural sciences, Physicians, Primary Care, 03 medical and health sciences, 0302 clinical medicine, Qualitative analysis, R5-920, Overuse, Medicine, Humans, Mass Screening, 030212 general & internal medicine, 0101 mathematics, Practice Patterns, Physicians', Aged, Oral hypoglycemic, business.industry, 010102 general mathematics, Deference, Primary care physician, Patient preference, Test (assessment), Choosing Wisely, Harm, Geriatrics, Family medicine, Older adults, Female, Family Practice, business, Research Article
Abstract: Background The objective is to understand why physicians order tests or treatments in older adults contrary to published recommendations. Methods Participants: Physicians above the median for ≥ 1 measures of overuse representing 3 Choosing Wisely topics. Measurements: Participants evaluated decisions in a semi-structured interview regarding: 1) Screening men aged ≥ 76 with prostate specific antigen 2) Ordering urine studies in women ≥ 65 without symptoms 3) Overtreating adults aged ≥ 75 with insulin or oral hypoglycemic medications. Two investigators independently coded transcripts using qualitative analysis. Results Nineteen interviews were conducted across the three topics resulting in four themes. First, physicians were aware and knowledgeable of guidelines. Second, perceived patient preference towards overuse influenced physician action even when physicians felt strongly that testing was not indicated. Third, physicians overestimated benefits of a test and underemphasized potential harms. Fourth, physicians were resistant to change when patients appeared to be doing well. Conclusions Though physicians expressed awareness to avoid overuse, deference to patient preferences and the tendency to distort the chance of benefit over harm influenced decisions to order testing. Approaches for decreasing unnecessary testing must account for perceived patient preferences, make the potential harms of overtesting salient, and address clinical inertia among patients who appear to be doing well.
Published: 2021

50. Peri-anastomotic microdialysis lactate assessment after esophagectomy

Author: Magnus Sundbom, Jakob Hedberg, and Gustav Linder
Subjects: medicine.medical_specialty, Leak, Microdialysis, medicine.medical_treatment, Anastomosis, 03 medical and health sciences, 0302 clinical medicine, Esophagus, Postoperative Complications, Anastomotic leaks, medicine, Anastomotic leak, Humans, Lactic Acid, business.industry, Kirurgi, Anastomosis, Surgical, Gastroenterology, Surgery, Esophagectomy, medicine.anatomical_structure, Intrathoracic anastomosis, Cardiothoracic surgery, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, business
Abstract: Background Esophagectomy is the cornerstone in curative treatment for esophageal and gastroesophageal junctional cancer. Esophageal resection is an advanced procedure with many complications, whereof anastomotic leak is the most dreaded. This study aimed to monitor the microcirculation with microdialysis analysis of local lactate levels in real-time on both sides of the esophagogastric anastomosis in totally minimally invasive Ivor-Lewis esophagectomy. Materials and Methods Twenty-five patients planned for esophageal resection with gastric conduit reconstruction and intrathoracic anastomosis were recruited. A sampling device, the OnZurf® Probe, along with the CliniSenz® Analyser (Senzime AB, Uppsala Sweden) was utilized for measurements. Lactate levels from both sides of the anastomosis were analysed in real time, on site, by a transportable analyser device. Measurements were made every 30 min during the first 24 h, and thereafter every 2 hours for up to 4 days. Results All probes could be positioned as planned and on the third postoperative day 19/25 and 15/25 of the esophageal and gastric probes, respectively, continued to deliver measurements. In total, 89.6% (1539/1718) and 72.4% (1098/1516) of the measurements were deemed successful. The average lactate level on the esophageal side of the anastomosis and the gastric conduit ranged between 1.1–11.5 and 0.8–7.0 mM, respectively. Two anastomotic leaks occurred, one of which had persisting high lactate levels on the gastric side of the anastomosis. Conclusion Application and use of the novel CliniSenz® analyser system, in combination with the OnZurf® Probe was feasible and safe. Continuous monitoring of analytes from the perianastomotic area has the potential to improve care after esophageal resection.
Published: 2021

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