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Objective: To compare the safety and efficacy of anti-leukotrienes and inhaled glucocorticoids as monotherapy in people with asthma. Design: Systematic review of randomised controlled trials comparing anti-leukotrienes with inhaled glucocorticoids for 28 days or more in children and adults. Main outcome measure: Rate of exacerbations that required treatment with systemic glucocorticoids. Results: 13 trials (12 in adults, one in children) met the inclusion criteria; all were in people with mild and moderate asthma. Leukotriene receptor antagonists were compared with inhaled glucocorticoids at a daily dose equivalent to 400–450 μg beclometasone dipropionate. Patients treated with leukotriene receptor antagonists were 60% more likely to suffer an exacerbation requiring systemic glucocorticoids (relative risk 1.6, 95% confidence interval 1.2 to 2.2; number needed to treat 27, 13 to 81). A 130 ml greater improvement (80 ml to 170 ml) in forced expiratory volume in one second and a 19 l/min greater increase (14 l to 24 l) in morning peak expiratory flow rate were noted in favour of inhaled glucocorticoids. Differences in favour of inhaled glucocorticoids were also observed for nocturnal awakenings, use of rescue β2 agonists, and days without symptoms. Risk of side effects was no different between groups, but leukotriene receptor antagonists were associated a 2.5-fold increase risk of withdrawals due to poor asthma control (relative risk 2.5, 1.8 to 3.5). Conclusions: Inhaled glucocorticoids doses equivalent to 400 μg/day beclometasone are more effective than leukotriene receptor antagonists in the treatment of adults with mild or moderate asthma. There is insufficient evidence to conclude on the efficacy of anti-leukotrienes in children. What is already known on this topic In 2000 a Cochrane systematic review tentatively concluded that control of asthma was better in patients treated with inhaled glucocorticoids as single agents than with anti-leukotrienes The 2002 Global Initiative for Asthma guidelines still classify the role of anti-leukotrienes as “under investigation” What this study adds Anti-leukotrienes as single agent are less effective than low doses of inhaled glucocorticoids for patients with mild and moderate persistent asthma

The sufficient utilization of the mega data acquired from operative power units is a promising way leading to high efficient, clean and safe operation of power plant. Hereinto, data filtering is a critical link to the data-driven dynamic model identification aiming at optimizing the process control. The machine learning is an advantageous approach for filtering usable data from mega databases for identification due to its effective statistical learning strategy to the field data with noises, disturbances and coupling quantities. Therefore, a data filtering method of combining Gaussian Naive Bayesian classifier and prediction error method (Gaussian NB-PEM) is proposed in this paper. Firstly, variables associated with identification model are selected by analyzing the characteristics of the process. Secondly, the GaussianNB classifier is used for coarse data filtering by calculating the priori probability of each attribute from training sample set and the probability with all possible values of the known categories for testing sample set. Thirdly, the prediction error method is used for further data filtering based on model fitting. By using the filtered closed-loop data, the dynamic characteristics of the superheated steam temperature is modeled and verified by closed-loop control simulation, showing the validity of the Gaussian NB-PEM data filtering method.

Essentially, the difficulty in dehydration technology of lignite depends on the energy state of water in lignite. The fundamental understanding of the water occurrence and energy state in lignite as well as its physical-chemical interaction with coal structure is helpful to the upgrading of lignite. In this paper, the water occurrence in lignite and the changes of oxygen-containing functional groups, pore structure, and water holding capacities at different drying temperatures were researched by DSC, NMR, FTIR and BET, respectively. The binding energies (calculated by DFT using model compounds) of different forms of water in lignite were also summarized. The relationships between energy state and occurrence mode of water in lignite as well as dehydration difficulty and structural changes during dewatering were clarified. The Results show that the energy state of water in lignite divided into three levels. The water in free and pore is in the lowest energy level. Its binding force with coal is pretty weak. So this type of water is easily vaporized and re-adsorbed. It is the main in removed moisture. Generally, the temperature removed free water mainly focused on below 100 °C, and the dehydration temperature of pore water mainly focused on 100–200 °C. The water bonded in hydrogen-bond and capillary confinement is in the middle energy level. The dehydration temperature mainly focused on 200–400 °C. The oxygen-containing functional groups of samples change a little and the re-adsorbed property improves a little after dehydrated. The water mainly produced by chemical reaction above 400 °C is in the highest energy level. Though this type of water does not belong to the natural occurrence of water in lignite, the re-adsorbed property improves much, and it plays the key role in stabilizing the dehydrated lignite interface.

The paper presents a project of a prototype solution of a device for making inseparable crimped joints consisting in forming the material of two elements to be joined to each other with the use of punches. The work contains the assessment and analysis of the joints made in the stand with the use of various forming tools. Furthermore, the paper presents the analysis of the characteristic features of the new joints, as well as dependences in strength tests. The elements joined on the machine had been made of 5754 aluminium. This material and the presented joint are used in the construction of heat exchangers, such as water, oil coolers or condensers in the automotive or aircraft branch.

In this paper we present a parametric method for the identification of a horizontal positioning system for a billets unloading machine. The input-output models are obtained on the experimental models and on the priori information of the process. The obtained models are represented as second-order underdamped systems. The assessment of the models is made via simulation and a best fit model follows. In order to improve the current process performances, new automatic control structures for the positioning process can be derived using the determined model

Machining of highly abrasive carbon fibre reinforced polymer (CFRP) in the aerospace industry requires processes with excellent machining quality, sufficient tool lifetime and short cycle times. To reach these goals a detailed understanding of the physics of cutting and chip formation based on the tool geometry is necessary. This paper presents a fundamental study in milling of unidirectional CFRP focussing on variable process parameters, tool geometries and fibre orientations. A single-edged tool with cemented carbide inserts of variable macro geometry is utilised. The experiments are evaluated by 3D microscopy of the milled edges, detailed tool wear analyses and interpretation of cutting forces. The key conclusions from the experimental results are drawn to reach a better machining quality and increased tool lifetime. The delamination of top layer fibres from the ply below up to a certain distance from the milled edge, which depends on the forces at fibre cutting angle ϕ = 90°, has been identified as main quality issue. Force and tool wear models based on the measurement data are presented.

The classification of color image that contain skin pixel is a challenging process. It is challenging due to certain factor such as brightness, background similar to human skin represent the obstacles thereof. The basic approach of skin detection is color based classification. The human skin image is the composition of RGB color. The data values of skin is calculated by randomly sampling RGB color values of different face images which have different age, race, genders sets. However, its performance has not really been high because of the high overlapped degree between “skin” and “non-skin” pixels. This paper describes the linear norm fuzzy based twin support vector machine (LN-FTSVM)) approach for discriminate skin and non-skin data values of skin dataset and to enhance the skin recognition performance. The concept of fuzzy is resolved the unclassified and overlapped data region problems. If no decision function is positive for a data set, this data set is classified into a class with the large membership value. By computational experiments shows that Experiments result shows that the accuracy is improved by linear norm fuzzy based TSVM (LN-FTSVM)) over the conventional methods.

A medical genetics clinic is a unique and complex environment in which care requires a combination of medical knowledge, social intelligence, and emotional sensitivity. We offer a few pearls from our medical genetics clinic that we hope will help the pediatric or general dermatologist when caring for patients with known or suspected genetic disorders. This paper addresses five main topics: When is it more than just atopic dermatitis? How should the clinician approach blistering in the newborn period? What is mosaicism? When is genetic testing useful? Where can clinician, patients, and families turn for available resources?

Software frameworks are difficult for plugin developers to use, even when they are well designed and documented. Some of these difficulties stem from the many constraints that frameworks impose on plugin code. These constraints might restrict operations from being called on certain objects, or they might restrict how long an object is available. Additionally, the constraints are relative to the current context of the plugin, and they can involve multiple, interacting framework objects. This paper proposes a lightweight specification system and analysis to check plugins from a semantic perspective, rather than a purely structural view.

Delivering reliable service requires satisfactory operation of numerous line components, spanning significant geographical areas and subject to environmental, electrical, and mechanical stresses, plus normal aging. Conventional reliability practices use periodic maintenance to minimize failures, coupled with rapid restoration procedures when outages occur. Reliability statistics have shown little change in decades. Newer technologies can shorten outages, by automatically rerouting service to customers on healthy feeder segments, but they: require redundant paths for power flow; react only after outages occur; and often require communications with pole-mounted switches. Over the past decade, Texas A&M University has demonstrated that electrical waveforms, available via conventional substation-based CTs and PTs, contain evidence of failures, incipient failures, and improper operation of feeder equipment, often well before these conditions escalate and cause outages. This provides the basis for conditioned-based maintenance and outage avoidance. This paper provides examples, from operating feeders, demonstrating some of these advances.

Purpose – The purpose of this paper is to explore the issues arising for women and men in senior management in New Zealand and Australian universities where life course and career trajectories intersect, and analyses how the stereotypical masculinist culture of universities can create additional problems for women. Design/methodology/approach – The data presented here comes from 47 interviews undertaken with women (27) and men (20) senior managers – a total of 26 interviews from New Zealand universities and 21 from Australian universities. “Senior Management” was defined in this study as those academic managers with university wide responsibilities, who were currently in senior management positions. Findings – Life-course issues for women aspiring to senior management roles in universities are framed around hegemonic constructions of masculinity; notions of academic careers subsuming personal life in professional roles; and structural constraints making rational choice impossible for many women. Furthermore, the excessive hours worked in such roles equate with the definition of extreme jobs. The paper concludes that the way in which women and men in senior HE endeavour to balance work and family life differs but creates issues for them both. Research limitations/implications – The structure and operation of Australian and New Zealand universities make gender diversity and management difficult to operationalise, given the competing imperatives of work and other life course trajectories. It is crucial to reframe life course and career intersections are conceptualised to ensure that diversity can be maximised. Originality/value – This paper focuses on women and men in senior management positions in New Zealand and Australian universities, but the findings can be generalised to other countries with HE systems based on the British University model. In discussing how institutional culture affects the intersection of career and life course trajectories, this paper highlights the detrimental outcomes for individuals and the resultant lack of diversity in the sector.

The Cygnus Dual Beam Radiographic Facility consists of two identical radiographic sources each with a dose rating of ∼4-rad at 1 m, and a ∼1-mm diameter spot size. The development of the rod pinch diode (RPD) was responsible for the ability to meet these criteria. The RPD in each machine uses a 0.75-mm tungsten diameter tapered anode rod extended through a 9-mm diameter cathode aperture. When properly configured, the electron beam born off the aperture edge can self-insulate and pinch onto the tip of the rod creating an intense, small x-ray source. These sources are utilized in concert with an imaging system on complex experiments, which are single-shot, high-value events. In such an application there is an emphasis on machine performance (reliability and reproducibility). Vacuum quality is a significant determinator for source performance. In this paper we discuss the Cygnus Dual Beam Radiographic Facility, the associated vacuum systems, vacuum monitor calibration and a multi-purpose vacuum chamber. Vacuum system performance, using various enhancements, will be reported. Using the vacuum system enhancements, as well as other machine tweaks, recent source performance has improved. This new level of performance will be presented via dosimetry and electrical measurements.

Pressure regulators have a great impact on the runtime and energy savings of supersonic wind tunnels. In order to investigate this impact quantitatively the theoretical isentropic (ideal) equations for the supersonic wind tunnel flow were compared with viscous CFD computations. The theoretical model was extended include the flow from the outflow from the pressure vessel up to the wind tunnel. This theoretical model was solved with and without pressure regulation valve using a Runge-Kutta method. The differences in runtime and energy consumption for both configurations with and without pressure regulator as well as the derivation of the analytical model and the numerical solution are presented in detail in this paper.

This paper presents a method for characterizing chemical solutions using nanowire field effect transistors. A pulsed gate potential method is used to prevent instabilities related to the dynamics of ions and other charged species present in the solution. Applying this method realizes a significant increase of the stability of the drain current versus gate potential characteristics of the devices, enabling reproducible characterization of chemical solutions with nanowire field effect transistors in aqueous environments.

This paper examines 1,089 private equity (PE) backed and non-PE backed (pure) UK buy-outs, determinants of their survival, and their exit behaviour during the period of 1966-2004. Our results suggest that 56% of the pure sample buy-outs remained in a buy-out organisational form for at least seven years after the original buy-out transaction, thus lending support to views that buy-outs present long rather than short term form. PE backed buy-outs exhibit higher exit rates, fewer early (within 12 months) exits and fewer liquidations than their pure counterparts. Buy-outs sponsored by PE syndicates, those harvested during periods with strong market conditions and greater supply of PE funding, tend to have shorter longevity. The most notable difference between the survival experiences of PE backed and pure buy-outs is documented in IPO exits, where a significant number of pure buy-outs exit early to the Alternative Investment Market (AIM). © 2011 Blackwell Publishing Ltd.

From the point of view of a data warehouse system, collecting and receiving information from source systems is crucial for all subsequent business intelligence applications. Incoming information can generally be classified into two types: (1) the state-oriented data and (2) event-oriented data or transactional data, which contains information about the change performed by processes on the instances of information objects. On the way towards achieving the goal of a full-fledged active data warehouse it becomes more and more important to provide data with minimal latency. In this paper we focus on dimensional data which is provided by general data warehouse applications. The information transfer is performed via messages containing the change of information on the dimension instances. The proposed approach is able to validate the event-messages, reconstruct the complete history of the dimension and provide a well applicable ''comprehensive slowly changing dimension'' (cSCD) interface for queries on the historical and current state of the dimension. A description of the prototype implementation for this kind of an ''active integration'' in a data warehouse and a case study at T-Mobile conclude the paper.

Rework in construction projects can cause significant waste of cost and time. Within lean construction practice, rework minimisation is of most interest among project managers. However, less attention has been paid to investigating rework reduction or avoidance in the housing supply chain. Given the increasing costs incurred due to rework generation, innovative approaches to reduce and avoid rework throughout the housing supply chain has never been more urgently required. Elaborating the root causes of rework is essential as it clearly highlights the role of various supply chain contributors. This paper investigates the root causes of rework in construction projects in general and in housing projects in particular. More specifically, the impact of rework on the entire housing supply chain will be explained.

Purpose The purpose of this paper is to explore how multinationality affects multinational companies’ (MNCs) downside risk and the moderate effects of ownership structure in the setting of emerging markets based on Chinese publicly traded manufacturing MNCs. Design/methodology/approach The author derives hypotheses based on real options theory and agency theory, and tests hypotheses by using Tobit model and a unique data set of Chinese A-shared publicly traded manufacturing MNCs in the period of 2010–2016. Findings The empirical results suggest that multinationality is positively related to downside risk and this effect is subjected to ownership structure for firms in emerging markets. In particular, multinationality of MNCs with a high level of ownership concentration, managerial ownership and institutional ownership is more likely to reduce downside risk. Practical implications The main conclusion of this paper highlights the importance of ownership structure of MNCs in explaining the real options value of multinationality, and conveys to owners of MNCs in China and other emerging markets the need to strengthen firms’ governance if they want to maximize the benefits of multinational operations. Originality/value This study extends existing studies by taking ownership structure into consideration and highlighting the importance of agency problem in the examination of multinationality and downside risk, which provides a potential explanation for previous mixed evidence. This study also provides new evidence for the relationship between multinationality and downside risk by using a unique sample from China, an emerging market country.