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2 results on '"Bahbahani H."'

1. Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia.

Author

Mastrangelo S, Bahbahani H, Moioli B, Ahbara A, Al Abri M, Almathen F, da Silva A, Belabdi I, Portolano B, Mwacharo JM, Hanotte O, Pilla F, and Ciani E

Subjects
Africa, Animals, Asia, Genome-Wide Association Study, Genotype, Homozygote, Phenotype, Polymorphism, Single Nucleotide, Body Fat Distribution, Breeding, Selection, Genetic, Sheep genetics
Abstract

Genomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations. In this study, we analyzed 50K SNP genotype data of 373 animals belonging to 23 sheep breeds of different geographic origins using the Rsb (extended haplotype homozygosity) and FST statistical approaches, to identify loci associated with the fat-tail phenotype. We also checked if these putative selection signatures overlapped with regions of high-homozygosity (ROH). The analyses identified novel signals and confirmed the presence of selection signature in genomic regions that harbor candidate genes known to affect fat deposition. Several genomic regions that frequently appeared in ROH were also identified within each breed, but only two ROH islands overlapped with the putative selection signatures. The results reported herein provide the most complete genome-wide study of selection signatures for fat-tail in African and Eurasian sheep breeds; they also contribute insights into the genetic basis for the fat tail phenotype in sheep, and confirm the great complexity of the mechanisms that underlie quantitative traits, such as the fat-tail., Competing Interests: The authors have declared that no competing interests exist.

Published
2019
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2. Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia

Author

Abulgasim Ahbara, Elena Ciani, Baldassare Portolano, Anne Da Silva, Salvatore Mastrangelo, Faisal Almathen, Ibrahim Belabdi, Olivier Hanotte, B. Moioli, Hussain Bahbahani, Fabio Pilla, Joram M. Mwacharo, Mohammed Al Abri, University of Palermo, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), University Park, Misurata University, Sultan Qaboos University (SQU), King Faisal University - College of Agriculture and Food Sciences, King Faisal University (KFU), Génomique AniMale, Amélioration, Adaptation (GAMAA), PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Université de Saâd Dahlab [Blida] (USDB ), International Center for Agricultural Research in the Dry Areas [Jordanie] (ICARDA), Università degli Studi del Molise (Unimol), Università degli Studi di Bari Aldo Moro, Mastrangelo S., Bahbahani H., Moioli B., Ahbara A., Al Abri M., Almathen F., Da Silva A., Belabdi I., Portolano B., Mwacharo J.M., Hanotte O., Pilla F., and Ciani E.

Subjects
0301 basic medicine, Candidate gene, Topography, European People, Heredity, [SDV]Life Sciences [q-bio], Social Sciences, Genome-wide association study, Breeding, Biochemistry, Homozygosity, Nucleotide diversity, Fats, Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico, Cell Signaling, Genotype, Psychology, Ethnicities, Body Fat Distribution, 2. Zero hunger, Mammals, Islands, sheep, fat tail, SNP, selection sigantures, candidate genes, Multidisciplinary, Animal Behavior, Homozygote, Eukaryota, Single Nucleotide, 04 agricultural and veterinary sciences, Ruminants, Phenotype, Lipids, Breed, Italian People, Africa, Animals, Asia, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Sheep, Selection, Genetic, Vertebrates, Medicine, Genomic Signal Processing, Research Article, Signal Transduction, Science, Single-nucleotide polymorphism, Genomics, Quantitative trait locus, Biology, Animal Sexual Behavior, Molecular Genetics, 03 medical and health sciences, Genetic, Genetics, SNP, Polymorphism, Selection, Molecular Biology, Selection (genetic algorithm), Behavior, Landforms, 0402 animal and dairy science, Organisms, Biology and Life Sciences, Geomorphology, Cell Biology, 040201 dairy & animal science, 030104 developmental biology, Evolutionary biology, Amniotes, People and Places, Earth Sciences, Population Groupings, Zoology
Abstract

International audience; Genomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations. In this study, we analyzed 50K SNP genotype data of 373 animals belonging to 23 sheep breeds of different geographic origins using the Rsb (extended haplotype homozygosity) and FST statistical approaches, to identify loci associated with the fat-tail phenotype. We also checked if these putative selection signatures overlapped with regions of high-homozygosity (ROH). The analyses identified novel signals and confirmed the presence of selection signature in genomic regions that harbor candidate genes known to affect fat deposition. Several genomic regions that frequently appeared in ROH were also identified within each breed, but only two ROH islands overlapped with the putative selection signatures. The results reported herein provide the most complete genome-wide study of selection signatures for fat-tail in African and Eurasian sheep breeds; they also contribute insights into the genetic basis for the fat tail phenotype in sheep, and confirm the great complexity of the mechanisms that underlie quantitative traits, such as the fat-tail.

Published
2019
Full Text
View/download PDF

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