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Your search keyword '"Du, Wenpei"' showing total 2 results
Start Over Author "Du, Wenpei" Topic breast neoplasms
2 results on '"Du, Wenpei"'

1. 3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells.

Author

Lei K, Du W, Lin S, Yang L, Xu Y, Gao Y, Xu B, Tan S, Xu Y, Qian X, Liang X, and Liu J

Subjects
Adenosine Triphosphate metabolism, Base Sequence, Breast Neoplasms genetics, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic drug effects, Glucose, Heterocyclic Compounds, 4 or More Rings chemistry, Humans, Janus Kinases metabolism, L-Lactate Dehydrogenase metabolism, Lactic Acid metabolism, Models, Biological, Photosensitizing Agents chemistry, STAT3 Transcription Factor metabolism, Suppressor of Cytokine Signaling Proteins metabolism, Breast Neoplasms pathology, Feedback, Physiological drug effects, Glycolysis drug effects, Heterocyclic Compounds, 4 or More Rings pharmacology, Inflammation pathology, MicroRNAs metabolism, Photosensitizing Agents pharmacology, Signal Transduction
Abstract

Compared to normal cells, most cancer cells produce ATP by glycolysis under aerobic conditions rather than via the tricarboxylic acid cycle (TCA). This study is intended to determine whether 3B, a novel photosensitizer, can inhibit glycolysis and inflammation in breast cancer cells. We showed that 3B had the ability to repress glucose consumption as well as the generation of ATP, lactate and lactate dehydrogenase. 3B-PDT not only inhibited the expression of IL-1β and IL-6 but also affected the JAK-STAT3 inflammatory pathway in vitro. The present study showed that 3B featured a significant inhibitory effect on the expression of microRNA-155-5p and SOCS1 might serve as a target gene. In vivo studies revealed that 3B inhibited tumor growth and exhibited almost no side effects. Therefore, through the anti-glycolytic effect and breakage of the JAK/STAT3/SOCS1 feedback loop via miR-155-5p, 3B may potentially serve as a potential therapeutic agent against breast cancer., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)

Published
2016
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2. 3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells.

Author

Lei K, Tan S, Du W, Xu Y, Lin S, Zheng Y, Zou F, Xu Y, and Liu J

Subjects
Animals, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Cell Proliferation drug effects, Female, Humans, MCF-7 Cells, Mice, Mitochondria drug effects, Mitochondria pathology, Proto-Oncogene Proteins c-bcl-2 biosynthesis, Signal Transduction drug effects, Xenograft Model Antitumor Assays, Apoptosis drug effects, Breast Neoplasms genetics, Imides administration & dosage, Phenalenes administration & dosage, Photochemotherapy, Photosensitizing Agents administration & dosage
Abstract

Photodynamic therapy (PDT) has been recognized as an innovated therapeutic modality for the treatment of various cancers. In this study, we evaluated the anticancer effect of a new photosensitizer 3B in breast cancer, which was considered one of the most common cancers in women worldwide. Here, we determined the effect of 3B not only on the cell growth, apoptosis, and Bcl-2 signal pathway in vitro but also on the anti-cancer effect in nude mice in vivo. Our results showed that 3B was primarily accumulated in mitochondria, increased the level of ROS, induced apoptotic cells death via Bcl-2 family, and its activity could be blocked by the caspase inhibitor (Z-VAD-FMK). In vivo study, 3B made a significant opening inhibition of tumor growth and showed drug toxicity hardly. TUNEL assay indicated that PDT group showed more positive cells (green) than other groups. These data supported that 3B might develop as potential therapeutic drug for the treatment of breast cancer.

Published
2015
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