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3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Jul; Vol. 36 (7), pp. 5597-606. Date of Electronic Publication: 2015 Feb 27. - Publication Year :
- 2015
-
Abstract
- Photodynamic therapy (PDT) has been recognized as an innovated therapeutic modality for the treatment of various cancers. In this study, we evaluated the anticancer effect of a new photosensitizer 3B in breast cancer, which was considered one of the most common cancers in women worldwide. Here, we determined the effect of 3B not only on the cell growth, apoptosis, and Bcl-2 signal pathway in vitro but also on the anti-cancer effect in nude mice in vivo. Our results showed that 3B was primarily accumulated in mitochondria, increased the level of ROS, induced apoptotic cells death via Bcl-2 family, and its activity could be blocked by the caspase inhibitor (Z-VAD-FMK). In vivo study, 3B made a significant opening inhibition of tumor growth and showed drug toxicity hardly. TUNEL assay indicated that PDT group showed more positive cells (green) than other groups. These data supported that 3B might develop as potential therapeutic drug for the treatment of breast cancer.
- Subjects :
- Animals
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Cell Proliferation drug effects
Female
Humans
MCF-7 Cells
Mice
Mitochondria drug effects
Mitochondria pathology
Proto-Oncogene Proteins c-bcl-2 biosynthesis
Signal Transduction drug effects
Xenograft Model Antitumor Assays
Apoptosis drug effects
Breast Neoplasms genetics
Imides administration & dosage
Phenalenes administration & dosage
Photochemotherapy
Photosensitizing Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 36
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25722114
- Full Text :
- https://doi.org/10.1007/s13277-015-3231-7