1. Functional MRI reveals activation of a subcortical network in a 5-year-old girl with genetically confirmed myoclonus-dystonia.
- Author
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Nitschke MF, Erdmann C, Trillenberg P, Sprenger A, Kock N, Sperner J, and Klein C
- Subjects
- Child, Preschool, Dystonia genetics, Dystonia pathology, Female, Hand, Humans, Magnetic Resonance Imaging, Myoclonus genetics, Myoclonus pathology, Brain pathology, Brain physiopathology, Dystonia physiopathology, Movement physiology, Myoclonus physiopathology
- Abstract
We investigated a five-year-old girl suffering from genetically confirmed, action-induced myoclonus-dystonia (M-D) with functional magnetic resonance imaging (MRI). We compared the activation pattern by movements of her right hand as if drawing a picture, which elicited M-D, with simple snapping movements (without overt M-D). The drawing and snapping conditions resulted in activation of a motor network including the motor cortex, the putamen, and the cerebellar hemispheres. The direct comparison of the drawing condition with snapping as control revealed specific activations within the thalamus and the dentate nucleus. An age matched healthy control did not show significant activation within the thalamus or dentate nucleus.
- Published
- 2006
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