1. High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis - a randomized controlled trial.
- Author
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Holmøy T, Lindstrøm JC, Eriksen EF, Steffensen LH, and Kampman MT
- Subjects
- Adult, Biomarkers blood, Bone Density Conservation Agents administration & dosage, Cholecalciferol administration & dosage, Dietary Supplements, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting blood, Osteoporosis blood, Treatment Outcome, Vitamin D blood, Young Adult, Bone Density Conservation Agents pharmacology, Cholecalciferol pharmacology, Multiple Sclerosis, Relapsing-Remitting drug therapy, Osteoporosis prevention & control, Vitamin D analogs & derivatives
- Abstract
Background: People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression and to maintain bone health., Methods: We assessed the effect of 20,000 IU vitamin D
3 weekly compared to placebo on biochemical markers of bone metabolism in 68 persons with relapsing remitting multiple sclerosis., Results: Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group, and parathyroid hormone decreased in the vitamin D group compared to the placebo group at week 48 and week 96. There was however no effect on bone formation as measured by procollagen type I N propeptide (PINP), or on bone resorption as measured by C-terminal cross-linking telopeptide of type I collagen (CTX1). Neither PINP nor CTX1 predicted bone loss from baseline to week 96., Conclusions: These findings corroborate the previously reported lack of effect of weekly high dose vitamin D supplementation on bone mass density in the same patients, and suggest that such vitamin D supplementation does not prevent bone loss in persons with MS who are not vitamin D deficient., Trial Registration: The trial was registered at ClinicalTrials.gov on April 4 2008, registration number NCT00785473 .- Published
- 2017
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