Back to Search
Start Over
High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis - a randomized controlled trial.
- Source :
-
BMC neurology [BMC Neurol] 2017 Apr 04; Vol. 17 (1), pp. 67. Date of Electronic Publication: 2017 Apr 04. - Publication Year :
- 2017
-
Abstract
- Background: People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression and to maintain bone health.<br />Methods: We assessed the effect of 20,000 IU vitamin D <subscript>3</subscript> weekly compared to placebo on biochemical markers of bone metabolism in 68 persons with relapsing remitting multiple sclerosis.<br />Results: Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group, and parathyroid hormone decreased in the vitamin D group compared to the placebo group at week 48 and week 96. There was however no effect on bone formation as measured by procollagen type I N propeptide (PINP), or on bone resorption as measured by C-terminal cross-linking telopeptide of type I collagen (CTX1). Neither PINP nor CTX1 predicted bone loss from baseline to week 96.<br />Conclusions: These findings corroborate the previously reported lack of effect of weekly high dose vitamin D supplementation on bone mass density in the same patients, and suggest that such vitamin D supplementation does not prevent bone loss in persons with MS who are not vitamin D deficient.<br />Trial Registration: The trial was registered at ClinicalTrials.gov on April 4 2008, registration number NCT00785473 .
- Subjects :
- Adult
Biomarkers blood
Bone Density Conservation Agents administration & dosage
Cholecalciferol administration & dosage
Dietary Supplements
Female
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting blood
Osteoporosis blood
Treatment Outcome
Vitamin D blood
Young Adult
Bone Density Conservation Agents pharmacology
Cholecalciferol pharmacology
Multiple Sclerosis, Relapsing-Remitting drug therapy
Osteoporosis prevention & control
Vitamin D analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2377
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28376767
- Full Text :
- https://doi.org/10.1186/s12883-017-0851-0