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The authors examined internalizing behavior problems at middle childhood, adolescence, and young adulthood and brain-based measures of stress vulnerability in 154 right-handed, nonimpaired young adults (M age = 23 years): 71 (30 males, 41 females) born at extremely low birth weight (ELBW; less than 1,000 g) and 83 (35 males, 48 females) controls born at normal birth weight (NBW). Internalizing behavior problems increased from adolescence to young adulthood among ELBW individuals. ELBW adults exhibited greater relative right frontal electroencephalogram activity at rest and more concurrent internalizing behavior problems than NBW controls. Being born at ELBW may have subtle influences on brain-behavior relations even in survivors without major impairments and evidence of these influences may not emerge until young adulthood. (Contains 5 tables and 2 figures.)

The article presents a study which aims to examine the effectiveness of Levofloxacin in treating cystic fibrosis (CF) patients. Numerous data revealed that CF levofloxacin pharmacokinetics corrected for body weight are similar to non-CF but the standard levofloxacin dosing is unlikely to produce maximum therapeutic effectiveness. Thus, further levofloxacin CF studies are essential to assess its phlegm concentrations for coping Pseudomonas Aeruginosa pulmonary infections.