1. A Physical Model-Based Approach to One-Point Calibration of Pulse Transit Time to Blood Pressure.
- Author
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Mousavi A, Inan OT, Mukkamala R, and Hahn JO
- Subjects
- Humans, Blood Pressure physiology, Calibration, Pulse Wave Analysis, Blood Pressure Determination, Arteries
- Abstract
Objective: To develop a novel physical model-based approach to enable 1-point calibration of pulse transit time (PTT) to blood pressure (BP)., Methods: The proposed PTT-BP calibration model is derived by combining the Bramwell-Hill equation and a phenomenological model of the arterial compliance (AC) curve. By imposing a physiologically plausible constraint on the skewness of AC at positive and negative transmural pressures, the number of tunable parameters in the PTT-BP calibration model reduces to 1. Hence, as opposed to most existing PTT-BP calibration models requiring multiple (≥2) PTT-BP measurements to personalize, the PTT-BP calibration model can be personalized to an individual subject using a single PTT-BP measurement pair. Equipped with the physically relevant PTT-AC and AC-BP relationships, the proposed approach may serve as a universal means to calibrate PTT to BP over a wide BP range. The validity and proof-of-concept of the proposed approach were evaluated using PTT and BP measurements collected from 22 healthy young volunteers undergoing large BP changes., Results: The proposed approach modestly yet significantly outperformed an empiric linear PTT-BP calibration with a group-average slope and subject-specific intercept in terms of bias (5.5 mmHg vs 6.4 mmHg), precision (8.4 mmHg vs 9.4 mmHg), mean absolute error (7.8 mmHg vs 8.8 mmHg), and root-mean-squared error (8.7 mmHg vs 10.3 mmHg, all in the case of diastolic BP)., Conclusion: We demonstrated the preliminary proof-of-concept of an innovative physical model-based approach to one-point PTT-BP calibration., Significance: The proposed physical model-based approach has the potential to enable more accurate and convenient calibration of PTT to BP.
- Published
- 2024
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