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1. STRUCTURE-ACTIVITY RELATIONSHIPS OF APIO NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS.

Author

Jeong, LakShin, Moon, HyungRyong, Hong, JunHee, Yoo, SuJeong, Choi, WonJun, Kim, HeaOk, Ahn, HeeSung, Baek, HyeWoo, Chun, MoonWoo, Kim, Hee-Doo, Kim, Jeongmin, and Choi, Jong-Ryoo

Subjects
NUCLEOSIDES, BIOSYNTHESIS, ANTIVIRAL agents, HIV
Abstract

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity. [ABSTRACT FROM AUTHOR]

Published
2001
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2. SYNTHESIS AND ANTIVIRAL ACTIVITY OF D- AND L-2′-AZIDO-2′,3′-DIDEOXY-4′-THIOPYRIMIDINE AND PURINE NUCLEOSIDES.

Author

Jeong, LakShin, Kim, YunHa, Kim, HeaOk, Yoo, SuJeong, Park, YongHee, Yeon, SookHee, Chun, MoonWoo, and Kim, Hee-Doo

Subjects
NUCLEOSIDES, BIOSYNTHESIS, ANTIVIRAL agents, HIV, HERPES simplex virus
Abstract

Novel D- and L-2′-azido-2′,3′-dideoxy-4′-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 μg/ml. [ABSTRACT FROM AUTHOR]

Published
2001
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