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STRUCTURE-ACTIVITY RELATIONSHIPS OF APIO NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS.
- Source :
- Nucleosides, Nucleotides & Nucleic Acids; Apr2001, Vol. 20 Issue 4-7, p657-660, 4p
- Publication Year :
- 2001
-
Abstract
- Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- NUCLEOSIDES
BIOSYNTHESIS
ANTIVIRAL agents
HIV
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 20
- Issue :
- 4-7
- Database :
- Complementary Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 8824605
- Full Text :
- https://doi.org/10.1081/NCN-100002344