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3 results on '"Straticell, Science Park Crealys"'

1. Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Author

Kananen L, Enroth L, Raitanen J, Jylhävä J, Bürkle A, Moreno-Villanueva M, Bernhardt J, Toussaint O, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom PE, Talbot DCS, Libert C, Koskinen S, Bruunsgaard H, Hansen ÅM, Lund R, Hurme M, and Jylhä M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Young Adult, Biomarkers blood, Biomarkers urine, Diagnostic Self Evaluation, Health Status, Self Report
Abstract

Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a comprehensive measure of health status and may even reflect the condition of the human organism beyond clinical diagnoses. Yet the biological basis of SRH is poorly understood. We used data from three independent European population samples (N approx. 15,000) to investigate the associations of SRH with 150 biomolecules in blood or urine (biomarkers). Altogether 57 biomarkers representing different organ systems were associated with SRH. In almost half of the cases the association was independent of disease and physical functioning. Biomarkers weakened but did not remove the association between SRH and mortality. We propose three potential pathways through which biomarkers may be incorporated into an individual's subjective health assessment, including (1) their role in clinical diseases; (2) their association with health-related lifestyles; and (3) their potential to stimulate physical sensations through interoceptive mechanisms. Our findings indicate that SRH has a solid biological basis and it is a valid but non-specific indicator of the biological condition of the human organism.

Published
2021
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2. MARK-AGE biomarkers of ageing.

Author

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, and Aspinall R

Subjects
European Union, Female, Humans, Male, Aging metabolism, Biomarkers metabolism
Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation., (Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)

Published
2015
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3. MARK-AGE biomarkers of ageing

Author

Jürgen Bernhard, Mikko Hurme, P. Eline Slagboom, Paola Caiafa, Tilman Grune, Alexander Bürkle, Olivier Toussaint, Michel Salmon, Daniela Gradinaru, Eugenio Mocchegiani, Efstathios S. Gonos, Ewa Sikora, Antti Hervonen, Claudio Franceschi, Peter Kristensen, Martijn E.T. Dollé, Sebastiano Collino, Beatrix Grubeck-Loebenstein, Maria A. Blasco, Duncan Talbot, Andreas Simm, Richard Aspinall, Claude Libert, Helen R. Griffiths, Jan H.J. Hoeijmakers, Gerben Zondag, Bertrand Friguet, Miriam Capri, Nicolle Breusing, Maria Moreno-Villanueva, University of Konstanz, BioTeSys GmbH, Esslingen, Spanish National Cancer Research Center (CNIO), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Université de Namur [Namur] (UNamur), Institute for Biomedical Aging Research, University of Innsbruck, Translational Research Center of Nutrition and Ageing (IRCCS-INRCA), Nestlé Institute of Health Sciences SA [Lausanne, Switzerland], National Hellenic Research Foundation, Nencki Institute of Experimental Biology, National Institute of Geriatrics and Gerontology 'Ana Aslan', National Institute for Public Health and the Environment [Bilthoven] (RIVM), Straticell, Science Park Crealys, Department of Engineering – BCE Protein Engineering, School of Life and Health Sciences, Aston University [Birmingham], Department for Molecular Biomedical Research (DFMBR), Universiteit Gent = Ghent University [Belgium] (UGENT)-VIB, University of Hohenheim, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], University Hospital Halle, CIG - Interdepartmental Center 'L.Galvani', Leiden University Medical Center (LUMC), Department of Cellular Biotechnologies and Hematology, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Medical School, University of Tampere [Finland], The MARK-AGE project has received funding from the European Union’s FP7 research and innovation programme under grant agreement HEALTH-F4-2008-200880, European Project: 200880,EC:FP7:HEALTH,FP7-HEALTH-2007-A,MARK-AGE(2008), Leopold Franzens Universität Innsbruck - University of Innsbruck, Universiteit Gent = Ghent University (UGENT)-VIB, Universiteit Leiden, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bürkle, Alexander, Moreno-Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H.J., Toussaint, Olivier, Grubeck-Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andrea, Franceschi, Claudio, Capri, Miriam, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard, Molecular Genetics, Spanish National Cancer Research Centre (CNIO), Université de Namur [Namur], Ghent University [Belgium] (UGENT)-VIB, Friedrich-Schiller-Universität Jena, Università degli Studi di Roma 'La Sapienza' [Rome], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Gerontology, Aging, MITOCHONDRIAL-DNA, Biological age, Single measurement, Scientific literature, Biology, 03 medical and health sciences, OLD-AGE, 0302 clinical medicine, Ageing biomarker, T-CELL SUBSETS, ddc:570, Humans, Ageing biomarkers, European commission, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, European Union, OXIDATIVE STRESS, 030304 developmental biology, Genetics, 0303 health sciences, INDUCED PREMATURE SENESCENCE, Human studies, Biology and Life Sciences, Human studie, APOLIPOPROTEIN-E GENOTYPE, REPLICATIVE SENESCENCE, MARK-AGE, Ageing, C-REACTIVE-PROTEIN, Human longevity, TELOMERE LENGTH, Female, Biomarkers, HUMAN LONGEVITY, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Published
2015
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