MARK-AGE biomarkers of ageing.

Authors :: Bürkle A
Moreno-Villanueva M
Bernhard J
Blasco M
Zondag G
Hoeijmakers JH
Toussaint O
Grubeck-Loebenstein B
Mocchegiani E
Collino S
Gonos ES
Sikora E
Gradinaru D
Dollé M
Salmon M
Kristensen P
Griffiths HR
Libert C
Grune T
Breusing N
Simm A
Franceschi C
Capri M
Talbot D
Caiafa P
Friguet B
Slagboom PE
Hervonen A
Hurme M
Aspinall R
Source :: Mechanisms of ageing and development [Mech Ageing Dev] 2015 Nov; Vol. 151, pp. 2-12. Date of Electronic Publication: 2015 Mar 24.
Publication Year :: 2015
Abstract: Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.<br /> (Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)