1. Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection
- Author
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Einari A. Niskanen, Maija Vihinen-Ranta, Elina Mäntylä, Teemu O. Ihalainen, and Faculty of Health Sciences
- Subjects
Parvovirus, Canine ,animal diseases ,viruses ,nuclear pore complexes ,Immunology ,Microbiology ,Parvoviridae Infections ,Capsid ,Dogs ,Virology ,medicine ,otorhinolaryngologic diseases ,Animals ,Dog Diseases ,Nuclear pore ,parvovovirus ,Cell Nucleus ,Nuclear Lamina ,Lamin Type B ,biology ,Parvovirus ,Parvovirus infection ,Canine parvovirus ,Lamin Type A ,biology.organism_classification ,medicine.disease ,Virus-Cell Interactions ,Cell biology ,Nuclear Pore Complex Proteins ,Cell nucleus ,stomatognathic diseases ,medicine.anatomical_structure ,Insect Science ,Nuclear Pore ,Nuclear lamina ,Nucleus ,Lamin - Abstract
Article, Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection., published version, http://purl.org/eprint/status/PeerReviewed
- Published
- 2015