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Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection

Authors :
Einari A. Niskanen
Maija Vihinen-Ranta
Elina Mäntylä
Teemu O. Ihalainen
Faculty of Health Sciences
Publication Year :
2015
Publisher :
American Society for Microbiology, 2015.

Abstract

Article<br />Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection.<br />published version<br />http://purl.org/eprint/status/PeerReviewed

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....ad97d786a61945d5bfbcd9cf4018112e