1. In vitro and in vivo comparison of eravacycline- and tigecycline-based combination therapies for tigecycline-resistant Acinetobacter baumannii
- Author
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Ti Yin, Tsung-Ta Chiang, Shu-Chen Kuo, Jiun-Ji Lai, Ya-Sung Yang, and Wei-Cheng Huang
- Subjects
Pharmacology ,Imipenem ,biology ,business.industry ,medicine.drug_class ,Antibiotics ,Tigecycline ,Drug resistance ,biochemical phenomena, metabolism, and nutrition ,Acinetobacter ,bacterial infections and mycoses ,biology.organism_classification ,Eravacycline ,Acinetobacter baumannii ,chemistry.chemical_compound ,Infectious Diseases ,Oncology ,chemistry ,medicine ,Colistin ,Pharmacology (medical) ,business ,medicine.drug - Abstract
Several antimicrobial combination therapies are used to treat multiple drug resistant (MDR) and extensively drug resistant (XDR) Acinetobacter baumannii infections. A novel antibiotic, eravacycline, shows a higher potency than tigecycline. The efficacies of eravacycline-based therapies have not yet been evaluated. We demonstrated the effectiveness of eravacycline- and tigecycline-based combination therapies in XDR and especially tigecycline resistant A. baumannii. Thirteen eligible isolates were selected from 642 non-duplicate Acinetobacter blood isolates from four medical centres in 2010-2014. Tigecycline/imipenem and eravacycline/imipenem combinations were simultaneously effective against some isolates in vitro with fractional inhibitory concentration index of 0.5. In contrast, eravacycline- and tigecycline-based combination therapies provided no additional benefits in mouse survival compared to those for monotherapy. In summary, colistin is still the final resort for XDR-A. baumannii treatment according to the sensitivities. Owning to rapid development of resistance in A. baumannii, novel antibiotics are urgently needed.
- Published
- 2021