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Clinical and molecular characterization of Acinetobacter seifertii in Taiwan
- Source :
- Journal of Antimicrobial Chemotherapy. 76:312-321
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Objectives Acinetobacter seifertii, a new member of the Acinetobacter baumannii group, has emerged as a cause of severe infections in humans. We investigated the clinical and molecular characteristics of A. seifertii. Patients and methods This retrospective study enrolled 80 adults with A. seifertii bloodstream infection (BSI) at four medical centres over an 8 year period. Species identification was confirmed by MALDI-TOF MS, rpoB sequencing and WGS. Molecular typing was performed by MLST. Clinical information, antimicrobial susceptibility and the mechanisms of carbapenem and colistin resistance were analysed. Transmissibility of the carbapenem-resistance determinants was examined by conjugation experiments. Results The main source of A. seifertii BSI was the respiratory tract (46.3%). The 28 day and in-hospital mortality rates of A. seifertii BSI were 18.8% and 30.0%, respectively. High APACHE II scores and immunosuppressant therapy were independent risk factors for 28 day mortality. The most common MLST type was ST553 (58.8%). Most A. seifertii isolates were susceptible to levofloxacin (86.2%), and only 37.5% were susceptible to colistin. Carbapenem resistance was observed in 16.3% of isolates, mostly caused by the plasmid-borne ISAba1-blaOXA-51-like genetic structure. A. seifertii could transfer various carbapenem-resistance determinants to A. baumannii, Acinetobacter nosocomialis and other A. seifertii isolates. Variations of pmrCAB and lpxCAD genes were not associated with colistin resistance of A. seifertii. Conclusions Levofloxacin and carbapenems, but not colistin, have the potential to be the drug of choice for A. seifertii infections. A. seifertii can transfer carbapenem-resistance determinants to other species of the A. baumannii group and warrants close monitoring.
- Subjects :
- Acinetobacter baumannii
Adult
Microbiology (medical)
Carbapenem
Taiwan
Microbial Sensitivity Tests
Acinetobacter seifertii
medicine.disease_cause
beta-Lactamases
Microbiology
Levofloxacin
polycyclic compounds
Humans
Medicine
Pharmacology (medical)
Retrospective Studies
Pharmacology
Acinetobacter
biology
business.industry
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
rpoB
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
Colistin
bacteria
Multilocus sequence typing
business
Acinetobacter Infections
Multilocus Sequence Typing
medicine.drug
Acinetobacter nosocomialis
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....4a37a3057e1987d01cf7815eff77ff3a