1. Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
- Author
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Sung-Kyun Ko, Min Cheol Kwon, Toshihiko Nogawa, Jun-Pil Jang, Shunji Takahashi, Jong Seog Ahn, Jae-Hyuk Jang, and Hiroyuki Osada
- Subjects
biology ,Stereochemistry ,Neurotoxicity ,General Medicine ,biology.organism_classification ,medicine.disease ,Applied Microbiology and Biotechnology ,Neuroprotection ,Streptomyces ,Homocysteine-thiolactone ,chemistry.chemical_compound ,chemistry ,Neuroblastoma ,medicine ,Literature study ,Hydrogen peroxide ,Derivative (chemistry) ,Biotechnology - Abstract
A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Biological evaluation studies revealed that both 1 and 2 exhibit neuroprotective activity against 6-hydroxydopamine (6-OHDA) mediated neurotoxicity by blocking generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
- Published
- 2021