Back to Search
Start Over
Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334
- Source :
- Journal of natural products. 81(4)
- Publication Year :
- 2018
-
Abstract
- Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher’s method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.
- Subjects :
- Lipopolysaccharides
Lipopolysaccharide
Interleukin-1beta
Pharmaceutical Science
Nitric Oxide Synthase Type II
Fungus
Nitric Oxide
01 natural sciences
Analytical Chemistry
Nitric oxide
Cell Line
Dothideomycetes sp
chemistry.chemical_compound
Biological Factors
Mice
Drug Discovery
Animals
Pharmacology
biology
010405 organic chemistry
Interleukin-6
Tumor Necrosis Factor-alpha
Organic Chemistry
Anti-Inflammatory Agents, Non-Steroidal
Fungi
Interleukin
biology.organism_classification
Molecular biology
Pyrone
0104 chemical sciences
Nitric oxide synthase
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
Cyclooxygenase 2
Pyrones
biology.protein
Molecular Medicine
Tumor necrosis factor alpha
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 81
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....012603cd3bfc2e57545214bdf6293b63