1. Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies
- Author
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Quanyi Guo, Xu Li, Shuyun Liu, Zhiqiang Sun, Guangzhao Tian, Yu Yang, Jinmin Zhao, Zhen Yang, Xiang Sui, and Kangkang Zha
- Subjects
0301 basic medicine ,mesenchymal stem/stromal cell ,Cell type ,Medicine (General) ,Stromal cell ,Angiogenesis ,Receptors, Nerve Growth Factor ,Tropomyosin receptor kinase A ,Biology ,Concise Reviews ,nerve growth factor ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Humans ,Receptor, trkA ,Receptor ,P75NTR ,Neurons ,QH573-671 ,Concise Review ,TrkA ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,Cell Biology ,General Medicine ,cellular therapy ,Cell biology ,030104 developmental biology ,Nerve growth factor ,nervous system ,Cytology ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate the biological behaviors of MSCs. The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis. The regulatory effect of NGF on MSCs is thought to be achieved mainly through its binding to TrkA. p75NTR, another receptor of NGF, is regarded as a novel surface marker of MSCs. This review provides an overview of advances in understanding the roles of NGF and its receptors in MSCs as well as the effects of MSC‐derived NGF on other cell types, which will provide new insight for the optimization of MSC‐based therapy., In this study, the modulatory effect of exogenous nerve growth factor (NGF) on mesenchymal stem/stromal cell (MSC) functions and the paracrine effects of MSC‐derived NGF on other cell types are discussed. In particular, the cytological functions and superiority of p75NTR+ MSCs as the basis for utilizing p75NTR as a surface marker to identify MSCs is presented.
- Published
- 2021