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Your search keyword '"Spirastrella coccinea"' showing total 4 results
Start Over Descriptor "Spirastrella coccinea" Topic biology
4 results on '"Spirastrella coccinea"'

1. Isolation of Spirastrellolides A and B from a Marine Sponge Epipolasis sp. and Their Cytotoxic Activities

Author

Shigeru Okada, Kentaro Takada, Shigeki Matsunaga, Reiko Ueoka, Masashi Suzuki, Susumu Ohtsuka, and Yuji Ise

Subjects
Stereochemistry, Oceans and Seas, Pharmaceutical Science, Antineoplastic Agents, Marine Biology, Analytical Chemistry, Epipolasis, Drug Discovery, Botany, Animals, Humans, Cytotoxic T cell, Spiro Compounds, Spirastrella coccinea, China sea, Pharmacology, Marine biology, Molecular Structure, biology, Organic Chemistry, biology.organism_classification, Porifera, Sponge, Caribbean Region, Complementary and alternative medicine, Molecular Medicine, Macrolides, Drug Screening Assays, Antitumor, HeLa Cells
Abstract

Spirastrellolides A (1) and B (3) have been isolated as free acids from a marine sponge Epipolasis sp. collected in the East China Sea. These compounds had been isolated from the Caribbean marine sponge Spirastrella coccinea after conversion to the methyl ester. We examined the cytotoxic activities of 1 and 3 and found that the activities of the free acids are comparable to those of the corresponding methyl esters.

Published
2012

2. Spirastrellolide A: Revised Structure, Progress toward the Relative Configuration, and Inhibition of Protein Phosphatase 2A

Author

Raymond J. Andersen, Michel Roberge, Tamsin Tarling, Xidong Feng, David E. Williams, and Marshall Lapawa

Subjects
Phosphoprotein phosphatase, Chemical transformation, Molecular Structure, biology, Chemistry, Stereochemistry, Organic Chemistry, General Medicine, Protein phosphatase 2, biology.organism_classification, Biochemistry, Porifera, Inhibitory Concentration 50, Sponge, Phosphoprotein Phosphatases, Animals, Molecule, Inhibitory concentration 50, Spiro Compounds, Macrolides, Protein Phosphatase 2, Enzyme Inhibitors, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular, Spirastrella coccinea
Abstract

[structure: see text] The structure of spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been revised to accommodate new MS and chemical transformation data. Relative configurations of three major fragments of the molecule have been elucidated from ROESY and coupling constant data. Spirastrellolide A has been shown to be a potent and fairly selective inhibitor of protein phosphatase 2A.

Published
2004

3. ChemInform Abstract: Spirastrellolides C to G: Macrolides Obtained from the Marine Sponge Spirastrella coccinea

Author

Robert A. Keyzers, Raymond J. Andersen, Jenna L. Riffell, David E. Williams, Michel Roberge, Kaoru Warabi, and Kelsey Desjardine

Subjects
Sponge, biology, Stereochemistry, Chemistry, General Medicine, biology.organism_classification, Spirastrella coccinea
Abstract

Five new macrolides, spirastrellolides C (3) to G (7), have been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Their structures have been elucidated by a combination of spectroscopic analysis and chemical transformations.

Published
2008

4. Spirastrellolides C to G: macrolides obtained from the marine sponge Spirastrella coccinea

Author

Jenna L. Riffell, Michel Roberge, Robert A. Keyzers, Raymond J. Andersen, David E. Williams, Kaoru Warabi, and Kelsey Desjardine

Subjects
Magnetic Resonance Spectroscopy, biology, Chemistry, Organic Chemistry, Molecular Conformation, Stereoisomerism, Reference Standards, biology.organism_classification, Animal origin, Porifera, Sponge, Botany, Animals, Macrolides, Enzyme Inhibitors, Spirastrella coccinea
Abstract

Five new macrolides, spirastrellolides C (3) to G (7), have been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Their structures have been elucidated by a combination of spectroscopic analysis and chemical transformations.

Published
2007

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