1. Isolation of Spirastrellolides A and B from a Marine Sponge Epipolasis sp. and Their Cytotoxic Activities
- Author
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Shigeru Okada, Kentaro Takada, Shigeki Matsunaga, Reiko Ueoka, Masashi Suzuki, Susumu Ohtsuka, and Yuji Ise
- Subjects
Stereochemistry ,Oceans and Seas ,Pharmaceutical Science ,Antineoplastic Agents ,Marine Biology ,Analytical Chemistry ,Epipolasis ,Drug Discovery ,Botany ,Animals ,Humans ,Cytotoxic T cell ,Spiro Compounds ,Spirastrella coccinea ,China sea ,Pharmacology ,Marine biology ,Molecular Structure ,biology ,Organic Chemistry ,biology.organism_classification ,Porifera ,Sponge ,Caribbean Region ,Complementary and alternative medicine ,Molecular Medicine ,Macrolides ,Drug Screening Assays, Antitumor ,HeLa Cells - Abstract
Spirastrellolides A (1) and B (3) have been isolated as free acids from a marine sponge Epipolasis sp. collected in the East China Sea. These compounds had been isolated from the Caribbean marine sponge Spirastrella coccinea after conversion to the methyl ester. We examined the cytotoxic activities of 1 and 3 and found that the activities of the free acids are comparable to those of the corresponding methyl esters.
- Published
- 2012