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Isolation of Spirastrellolides A and B from a Marine Sponge Epipolasis sp. and Their Cytotoxic Activities
- Source :
- Journal of Natural Products. 75:1192-1195
- Publication Year :
- 2012
- Publisher :
- American Chemical Society (ACS), 2012.
-
Abstract
- Spirastrellolides A (1) and B (3) have been isolated as free acids from a marine sponge Epipolasis sp. collected in the East China Sea. These compounds had been isolated from the Caribbean marine sponge Spirastrella coccinea after conversion to the methyl ester. We examined the cytotoxic activities of 1 and 3 and found that the activities of the free acids are comparable to those of the corresponding methyl esters.
- Subjects :
- Stereochemistry
Oceans and Seas
Pharmaceutical Science
Antineoplastic Agents
Marine Biology
Analytical Chemistry
Epipolasis
Drug Discovery
Botany
Animals
Humans
Cytotoxic T cell
Spiro Compounds
Spirastrella coccinea
China sea
Pharmacology
Marine biology
Molecular Structure
biology
Organic Chemistry
biology.organism_classification
Porifera
Sponge
Caribbean Region
Complementary and alternative medicine
Molecular Medicine
Macrolides
Drug Screening Assays, Antitumor
HeLa Cells
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....b210004b7564678ebb6fdaafee558ff9