1. Placental endocrine function shapes cerebellar development and social behavior
- Author
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Jacob Ellegood, Sonia Sebaoui, Aaron Sathyanesan, Kazue Hashimoto-Torii, Vittorio Gallo, Anastas Popratiloff, Yuka Imamura, Helene Lacaille, Jason P. Lerch, Michael Schumacher, Jacquelyn Salzbank, Panagiotis Kratimenos, Jiaqi J. O’Reilly, Dana Bakalar, Claire Marie Vacher, Philippe Liere, Cheryl Clarkson-Paredes, Anna A. Penn, and Toru Sasaki
- Subjects
Agonist ,Male ,Cerebellum ,medicine.medical_specialty ,medicine.drug_class ,Offspring ,Autism Spectrum Disorder ,Neurogenesis ,Placenta ,Pregnanolone ,Biology ,Article ,chemistry.chemical_compound ,Mice ,Aldehyde Reductase ,Pregnancy ,Internal medicine ,Endocrine Glands ,medicine ,Animals ,Humans ,Receptor ,GABA Modulators ,Social Behavior ,GABA Agonists ,Sex Characteristics ,Muscimol ,General Neuroscience ,Allopregnanolone ,Infant, Newborn ,Infant ,Development of the nervous system ,Receptors, GABA-A ,White Matter ,Trophoblasts ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Diseases of the nervous system ,Female ,Neuroscience ,Gene Deletion ,Hormone ,Signal Transduction - Abstract
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in a sex-linked manner. A new conditional mouse model, in which the gene encoding ALLO’s synthetic enzyme (akr1c14) is specifically deleted in trophoblasts, directly demonstrated that placental ALLO insufficiency led to cerebellar white matter abnormalities that correlated with autistic-like behavior only in male offspring. A single injection of ALLO or muscimol, a GABAAR agonist, during late gestation abolished these alterations. Comparison of male and female human preterm infant cerebellum also showed sex-linked myelination marker alteration, suggesting similarities between mouse placental ALLO insufficiency and human preterm brain development. This study reveals a new role for a placental hormone in shaping brain regions and behaviors in a sex-linked manner. Placental hormone replacement might offer novel therapeutic opportunities to prevent later neurobehavioral disorders., Placental dysfunction has been implicated in abnormal neurodevelopment. Vacher et al. found that loss of a neuroactive hormone from the placenta alters brain development in a regional and sex-linked manner, resulting in autism-like behaviors in male offspring.
- Published
- 2021