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Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury
- Source :
- Glia. 57:884-897
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Progesterone is emerging as a myelinizing factor for central nervous system injury. Successful remyelination requires proliferation and differentiation of oligodendrocyte precursor cells (OPC) into myelinating oligodendrocytes (OL), but this process is incomplete following injury. To study progesterone actions on remyelination, we administered progesterone (16 mg/kg/day) to rats with complete spinal cord injury. Rats were euthanized 3 or 21 days after steroid treatment. Short progesterone treatment: a) increased the number of OPC without effect on the injury-induced reduction of mature OL; b) increased mRNA and protein expression for the myelin basic protein (MBP) without effects on proteolipid protein (PLP) or myelin oligodendrocyte glycoprotein (MOG) and c) increased the mRNA for Olig2 and Nkx2.2 transcription factors involved in specification and differentiation of the OL lineage. Furthermore, long progesterone treatment: a) reduced OPC with a concomitant increase of OL; b) promoted differentiation of cells that incorporated bromodeoxyuridine, early after injury, into mature OL; c) increased mRNA and protein expression of PLP without effects on MBP or MOG and d) increased mRNA for the Olig1 transcription factor involved in myelin repair. These results suggest that early progesterone treatment enhanced the density of OPC and induced their differentiation into mature OL by increasing the expression of Olig2 and Nkx2.2. Twenty one days after injury, progesterone favors remyelination by increasing Olig1 (involved in repair of demyelinated lesions), PLP expression and enhancing OL maturation. Thus, progesterone effects on oligodendrogenesis and myelin proteins may constitute fundamental steps for repairing traumatic injury inflicted to the spinal cord. Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Roig, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Guennoun, Rachida. Inserm; Francia Fil: Schumacher, Michael. Inserm; Francia Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
- Subjects :
- Male
Pathology
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Time Factors
Neurociencias
Nerve Tissue Proteins
Biology
SPINAL CORD INJURY
REMYELINATION
Rats, Sprague-Dawley
OLIG2
Cellular and Molecular Neuroscience
Myelin
Basic Helix-Loop-Helix Transcription Factors
medicine
Animals
RNA, Messenger
Progenitor cell
Remyelination
Myelin Proteolipid Protein
Spinal cord injury
Transcription factor
Progesterone
Spinal Cord Injuries
TRAUMA
Homeodomain Proteins
PROGESTERONE
Zebrafish Proteins
medicine.disease
Oligodendrocyte
Rats
Medicina Básica
Adult Stem Cells
Disease Models, Animal
Myelin-Associated Glycoprotein
Oligodendroglia
STEROID
Homeobox Protein Nkx-2.2
medicine.anatomical_structure
Gene Expression Regulation
Neurology
Myelin-Oligodendrocyte Glycoprotein
Progestins
Orchiectomy
Neuroscience
Myelin Proteins
Transcription Factors
Subjects
Details
- ISSN :
- 10981136 and 08941491
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Glia
- Accession number :
- edsair.doi.dedup.....da8e003fa051250d73e51d2091b5ef24