1. Anti-inflammatory and antiproliferative prenylated chalcones from Hedysarum gmelinii
- Author
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Ran Wen, Yu Ying Zhao, Yi Liu, Hong Liang, Jun Zhang, Hubiao Chen, and Guang Zhong Tu
- Subjects
medicine.drug_class ,Plant composition ,Anti-Inflammatory Agents ,Pharmaceutical Science ,01 natural sciences ,Anti-inflammatory ,Analytical Chemistry ,Mice ,Chalcones ,Prenylation ,Cell Line, Tumor ,Drug Discovery ,medicine ,Hedysarum ,Animals ,Humans ,Pharmacology ,Traditional medicine ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Fabaceae ,General Medicine ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Hedysarum gmelinii ,Molecular Medicine - Abstract
Five new prenylated chalcones hedysarumines C-G (1-5), along with eight known chalcones (6-13) all of which were isolated from the genus Hedysarum for the first time, were isolated from the roots of Hedysarum gmelinii by chromatographic methods. Their structures were determined by extensive spectroscopic techniques. The isolated chalcones (2-13) and previously isolated prenylated chalcones (14-16) were evaluated for antiproliferative activity against five human cancer cell lines (HepG2, A549, Du145, BGC823, and HCT116) and in vitro anti-inflammatory activity. Compounds 5, 10, and 15 inhibited NO production induced by lipopolysaccharide in BV-2 cells, with IC
- Published
- 2018