1. How to get away with liver innate immunity? A viruses’ tale
- Author
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Manon Desmares, Mathias Heikenwalder, Svenja Schuehle, Suzanne Faure-Dupuy, Marion Delphin, David Durantel, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Heidelberg University, Développement Cancer et Thérapies Ciblées [Lyon] (LabEx DEVweCAN), and Université de Lyon
- Subjects
PRR ,[SDV]Life Sciences [q-bio] ,Biology ,Major histocompatibility complex ,NF-κB ,chemistry.chemical_compound ,Immune system ,Interferon ,medicine ,innate immunity ,hepatic viruses ,anti-inflammatory ,Innate immune system ,Hepatology ,Pattern recognition receptor ,interferon ,biochemical phenomena, metabolism, and nutrition ,Phenotype ,Immunity, Innate ,pro-inflammatory ,Immune recognition ,Liver ,chemistry ,Receptors, Pattern Recognition ,Viruses ,Immunology ,biology.protein ,bacteria ,Interferons ,MHC ,medicine.drug - Abstract
International audience; In their never-ending quest towards persistence within their host, hepatitis viruses have developed numerous ways to counteract the liver innate immunity. This review highlights the different and common mechanisms employed by these viruses to (i) establish in the liver (passive entry or active evasion from immune recognition) and (ii) actively inhibit the innate immune response (ie modulation of pattern recognition receptor expression and/or signalling pathways, modulation of interferon response and modulation of immune cells count or phenotype).
- Published
- 2021