1. Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus
- Author
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Siow H. Teo, Chan Kiang Lim, Gwendoline Cheng Lian Ee, Choon Fah Joseph Bong, Yang Mooi Lim, and Mawardi Rahmani
- Subjects
Antioxidant ,food.ingredient ,biology ,Stereochemistry ,DPPH ,medicine.medical_treatment ,Organic Chemistry ,Cancer ,medicine.disease ,Moraceae ,biology.organism_classification ,Biochemistry ,Artocarpus odoratissimus ,chemistry.chemical_compound ,food ,chemistry ,medicine ,Two-dimensional nuclear magnetic resonance spectroscopy ,Lead compound ,Derivative (chemistry) - Abstract
Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).
- Published
- 2010
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