Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus

Authors :: Siow H. Teo
Chan Kiang Lim
Gwendoline Cheng Lian Ee
Choon Fah Joseph Bong
Yang Mooi Lim
Mawardi Rahmani
Source :: Letters in Organic Chemistry. 7:240-244
Publication Year :: 2010
Publisher :: Bentham Science Publishers Ltd., 2010.
Abstract: Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).