1. Does rotavirus turn on type 1 diabetes?
- Author
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Harrison, Leonard C., Perrett, Kirsten P., Jachno, Kim, Nolan, Terry M., and Honeyman, Margo C.
- Subjects
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TYPE 1 diabetes , *AUTOANTIBODIES , *CYTOLOGY , *MOLECULAR biology , *VACCINE effectiveness , *LIFE sciences , *ROTAVIRUS vaccines - Abstract
Recently, we observed a 15% decrease in the incidence of type 1 diabetes (T1D) in Australian 0-4-year-old children following the introduction of RV vaccination [[2], [3]], suggesting that RV vaccination could contribute to the primary prevention of this autoimmune disease. Australian surveillance data [[11]] show that the prevalence of RV G3 strains increased slightly along with an increase in strain diversity in the post-RV vaccine era, but G3 remains a minor component of disease-causing RV strains. RV was prevalent in nurseries, and the change to rooming-in would have altered the timing of exposure to RV, delaying it until later in the first year of life when, based on NOD mouse studies [[17]-[19]], RV might promote rather than retard development of diabetes. [Extracted from the article]
- Published
- 2019
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