1. The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats.
- Author
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Danilova RA, Rud'ko OI, Korotkova TM, Obukhova MF, and Ashmarin IP
- Subjects
- Alcohol Drinking immunology, Animals, Anxiety physiopathology, Conditioning, Operant drug effects, Depression psychology, Exploratory Behavior physiology, Fear physiology, Immunoenzyme Techniques, Male, Motor Activity physiology, Pain Measurement drug effects, Peptide Fragments immunology, Rats, Rats, Wistar, Swimming psychology, Anxiety immunology, Behavior, Animal physiology, Tetragastrin immunology
- Abstract
Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.
- Published
- 2002
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