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[Effect of immunization to cholecystokinin fragment (30-33) on the behavior of albino rats].
- Source :
-
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2000 Sep; Vol. 86 (9), pp. 1167-74. - Publication Year :
- 2000
-
Abstract
- Active immunisation of albino rats by the BSA-conjugated CCK-4 induced formation of antibodies to the CCK-4 and some long-term changes of the rat behaviour. These changes were contrary to anxiogenic effect of the CCK-4 and demonstrated an anxiolytic effect of the immunisation. The data obtained suggest a possibility of an immunocorrection of pathological anxiety and fear by an inverse immunoregulation.
- Subjects :
- Alcohol Drinking
Animals
Antibodies blood
Antibodies chemistry
Avoidance Learning drug effects
Enzyme-Linked Immunosorbent Assay
Exploratory Behavior drug effects
Maze Learning drug effects
Motor Activity drug effects
Pain Threshold
Rats
Rats, Wistar
Serum Albumin chemistry
Tetragastrin pharmacology
Vaccination
Antibodies pharmacology
Behavior, Animal drug effects
Tetragastrin immunology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-8139
- Volume :
- 86
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 11081222