1. Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
- Author
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Bar-Am O, Gross A, Friedman R, and Finberg JP
- Subjects
- Animals, Blood Pressure drug effects, Cardiovascular System enzymology, Cardiovascular System metabolism, Clorgyline adverse effects, Clorgyline pharmacology, Dose-Response Relationship, Drug, Heart Rate drug effects, Hypertension chemically induced, Hypotension chemically induced, Injections, Intravenous, Isoenzymes antagonists & inhibitors, Isoenzymes metabolism, Male, Monoamine Oxidase chemistry, Monoamine Oxidase Inhibitors administration & dosage, Monoamine Oxidase Inhibitors adverse effects, Pressoreceptors chemistry, Rats, Rats, Sprague-Dawley, Selegiline administration & dosage, Selegiline adverse effects, Selegiline pharmacology, Vasoconstrictor Agents administration & dosage, Vasoconstrictor Agents pharmacology, Vasodilator Agents administration & dosage, Vasodilator Agents pharmacology, Baroreflex drug effects, Cardiovascular System drug effects, Monoamine Oxidase metabolism, Monoamine Oxidase Inhibitors pharmacology, Pressoreceptors metabolism
- Abstract
Cardiovascular baroreceptor responsiveness of conscious rats treated with selective inhibitors of monoamine oxidase (MAO) types A and B was determined by measurement of blood pressure (BP) and heart rate (HR) responses to intravenous injection of phenylephrine and sodium nitroprusside. Treatment with selegiline (1 or 5 mg/kg p.o. daily for 7 days) did not significantly modify resting levels of BP and HR, lower or upper HR plateau levels, or HR/BP gain. Treatment with clorgyline (2 mg/kg p.o. daily for 7 days) increased HR/BP gain but also did not modify resting BP or HR, or lower and upper plateau levels of HR. The results are compatible with an effect of MAO-A inhibition to modify monoamine levels in medullary areas participating in CNS control of blood pressure., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
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