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Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2012 May 15; Vol. 683 (1-3), pp. 226-30. Date of Electronic Publication: 2012 Mar 23. - Publication Year :
- 2012
-
Abstract
- Cardiovascular baroreceptor responsiveness of conscious rats treated with selective inhibitors of monoamine oxidase (MAO) types A and B was determined by measurement of blood pressure (BP) and heart rate (HR) responses to intravenous injection of phenylephrine and sodium nitroprusside. Treatment with selegiline (1 or 5 mg/kg p.o. daily for 7 days) did not significantly modify resting levels of BP and HR, lower or upper HR plateau levels, or HR/BP gain. Treatment with clorgyline (2 mg/kg p.o. daily for 7 days) increased HR/BP gain but also did not modify resting BP or HR, or lower and upper plateau levels of HR. The results are compatible with an effect of MAO-A inhibition to modify monoamine levels in medullary areas participating in CNS control of blood pressure.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Blood Pressure drug effects
Cardiovascular System enzymology
Cardiovascular System metabolism
Clorgyline adverse effects
Clorgyline pharmacology
Dose-Response Relationship, Drug
Heart Rate drug effects
Hypertension chemically induced
Hypotension chemically induced
Injections, Intravenous
Isoenzymes antagonists & inhibitors
Isoenzymes metabolism
Male
Monoamine Oxidase chemistry
Monoamine Oxidase Inhibitors administration & dosage
Monoamine Oxidase Inhibitors adverse effects
Pressoreceptors chemistry
Rats
Rats, Sprague-Dawley
Selegiline administration & dosage
Selegiline adverse effects
Selegiline pharmacology
Vasoconstrictor Agents administration & dosage
Vasoconstrictor Agents pharmacology
Vasodilator Agents administration & dosage
Vasodilator Agents pharmacology
Baroreflex drug effects
Cardiovascular System drug effects
Monoamine Oxidase metabolism
Monoamine Oxidase Inhibitors pharmacology
Pressoreceptors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 683
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22465184
- Full Text :
- https://doi.org/10.1016/j.ejphar.2012.03.026