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We describe in this work the syntheses, characterization and antifungal activity of the complexes: [Ni{S 2 CNMe(R 1 )} 2 ] (1) , [Pd{S 2 CNMe(R 1 )} 2 ] (2) , [Pt{S 2 CNMe(R 1 )} 2 ] (3) , [Ni{S 2 CNMe(R 2 )} 2 ] (4) , [Pd{S 2 CNMe(R 2 )} 2 ] (5) , [Pt{S 2 CNMe(R 2 )} 2 ] (6) , {R 1 = CH 2 CH(OMe) 2 and R 2 = 2-methyl-1,3-dioxolane}. Complexes (1) – (6) have been characterized by IR and 1 H and 13 C NMR spectroscopy. In addition, the structures of (1) , (2) and (3) have been authenticated by X-ray diffraction. The antifungal activities of (1) – (6) have been screened against Aspergillus flavus , Aspergillus niger , Aspergillus parasiticus and Penicillium citrinum and the results, in the form of the minimum inhibition concentration (MIC), and compared with those of nystatin and miconazole nitrate, used as control drugs. All complexes had greater activity than nystatin. Palladium containing complexes, (2) and (5) , were the more active against A. flavus . The growth of A. niger , were more efficiently affected by Ni(II) complexes (1) and (4) and complex (6) was effective in reducing the colonies of A. parasiticus . [ABSTRACT FROM AUTHOR]

The two novel dithiocarbamate salts, [Na{S 2 CNR(R 1 )}] (i) , [Na{S 2 CNR(R 2 )}] (ii) , R = methyl, R 1 = CH 2 CH(OMe) 2 , R 2 = 2-methyl-1,3-dioxolane, previously synthesized by us, have been used in chemical reactions with triorganotin halides. Hence, five new complexes: [SnPh 3 {S 2 CNR(R 1 )}] (1) , [SnCy 3 {S 2 CNR(R 1 )}] (2) , [SnMe 3 {S 2 CNR(R 2 )}] (3) , [SnPh 3 {S 2 CNR(R 2 )}] (4) and [SnCy 3 {S 2 CNR(R 2 )}] (5) , [R = methyl, R 1 = CH 2 CH(OMe) 2 , and R 2 = 2-methyl-1,3-dioxolane], have been isolated. All compounds were authenticated in terms of infrared, 1 H and 13 C NMR, and the complexes were also characterized using 119 Sn NMR, 119 Sn Mössbauer and X-ray crystallography, in the case of complexes (1) , (4) and (5) . The biological activity of all derivatives has been screened in terms of IC 90 (μmol L −1 ) and IC 50 (μmol L −1 ) against Aspergillus flavus , Aspergillus niger , Aspergillus parasiticus and Penicillium citrinum , and the results correlated well with a performed study of structure–activity relationship (SAR). Complexes (1) and (4) displayed nanomolar inhibition concentration in terms of IC 50 . [ABSTRACT FROM AUTHOR]