Design, structural and spectroscopic elucidation, and the in vitro biological activities of new triorganotin dithiocarbamates – Part II.

The two novel dithiocarbamate salts, [Na{S 2 CNR(R 1 )}] (i) , [Na{S 2 CNR(R 2 )}] (ii) , R = methyl, R 1 = CH 2 CH(OMe) 2 , R 2 = 2-methyl-1,3-dioxolane, previously synthesized by us, have been used in chemical reactions with triorganotin halides. Hence, five new complexes: [SnPh 3 {S 2 CNR(R 1 )}] (1) , [SnCy 3 {S 2 CNR(R 1 )}] (2) , [SnMe 3 {S 2 CNR(R 2 )}] (3) , [SnPh 3 {S 2 CNR(R 2 )}] (4) and [SnCy 3 {S 2 CNR(R 2 )}] (5) , [R = methyl, R 1 = CH 2 CH(OMe) 2 , and R 2 = 2-methyl-1,3-dioxolane], have been isolated. All compounds were authenticated in terms of infrared, 1 H and 13 C NMR, and the complexes were also characterized using 119 Sn NMR, 119 Sn Mössbauer and X-ray crystallography, in the case of complexes (1) , (4) and (5) . The biological activity of all derivatives has been screened in terms of IC 90 (μmol L −1 ) and IC 50 (μmol L −1 ) against Aspergillus flavus , Aspergillus niger , Aspergillus parasiticus and Penicillium citrinum , and the results correlated well with a performed study of structure–activity relationship (SAR). Complexes (1) and (4) displayed nanomolar inhibition concentration in terms of IC 50 . [ABSTRACT FROM AUTHOR]