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1. A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid.

Author

Tai A, Aburada M, and Ito H

Subjects
Animals, Ascorbic Acid chemical synthesis, Ascorbic Acid chemistry, Ascorbic Acid pharmacology, Bromides chemistry, Bucladesine metabolism, Calcium metabolism, Cell Survival drug effects, PC12 Cells, Rats, Ascorbic Acid analogs & derivatives, Neurites drug effects
Abstract

A single-step synthesis of 3-O-ethyl-l-ascorbic acid was performed without the induction of protecting groups. Sodium l-ascorbate reacted with ethyl bromide in DMSO to give 3-O-ethylascorbic acid in a yield of 51.0%. 3-O-Ethylascorbic acid enhanced dibutyryl cyclic AMP-induced neurite outgrowth in PC12 cells.

Published
2014
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