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A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid.

Authors :
Tai A
Aburada M
Ito H
Source :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2014; Vol. 78 (12), pp. 1984-7. Date of Electronic Publication: 2014 Aug 15.
Publication Year :
2014

Abstract

A single-step synthesis of 3-O-ethyl-l-ascorbic acid was performed without the induction of protecting groups. Sodium l-ascorbate reacted with ethyl bromide in DMSO to give 3-O-ethylascorbic acid in a yield of 51.0%. 3-O-Ethylascorbic acid enhanced dibutyryl cyclic AMP-induced neurite outgrowth in PC12 cells.

Details

Language :
English
ISSN :
1347-6947
Volume :
78
Issue :
12
Database :
MEDLINE
Journal :
Bioscience, biotechnology, and biochemistry
Publication Type :
Academic Journal
Accession number :
25127395
Full Text :
https://doi.org/10.1080/09168451.2014.946396