1. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes T
- Author
-
Sevgi, Keles, Louis Marie, Charbonnier, Venkataraman, Kabaleeswaran, Ismail, Reisli, Ferah, Genel, Nesrin, Gulez, Waleed, Al-Herz, Narayanaswamy, Ramesh, Antonio, Perez-Atayde, Neslihan E, Karaca, Necil, Kutukculer, Hao, Wu, Raif S, Geha, and Talal A, Chatila
- Subjects
Male ,STAT3 Transcription Factor ,Immunologic Deficiency Syndromes ,Infant ,Cell Differentiation ,Article ,Jurkat Cells ,Protein Transport ,Child, Preschool ,Mutation ,Guanine Nucleotide Exchange Factors ,Humans ,Th17 Cells ,Female ,Phosphorylation ,Child ,Autoantibodies - Abstract
The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES because of signal transducer and activator of transcription 3 (STAT3) mutations, including recurrent infections and mucocutaneous candidiasis, which are suggestive of TWe sought to elucidate common mechanisms operating in the different forms of HIES.We analyzed the differentiation of CD4There was a profound block in the differentiation of DOCK8-deficient naive CD4DOCK8 interacts with STAT3 and regulates its activation and the outcome of STAT3-dependent T
- Published
- 2016