1. [Lipoprotein(a) and Apo-A isoforms in patients with intermittent claudication].
- Author
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Britareva VV, Afanas'eva OI, Dobrovol'skiĭ AB, Ezhov MV, Titaeva EV, Karpov IuA, and Pokrovskiĭ SN
- Subjects
- Aged, Apolipoproteins A genetics, Arteriosclerosis blood, Chi-Square Distribution, Data Interpretation, Statistical, Female, Humans, Intermittent Claudication etiology, Lipoprotein(a) genetics, Male, Middle Aged, Molecular Weight, Phenotype, Apolipoproteins A blood, Intermittent Claudication blood, Lipoprotein(a) blood
- Abstract
Aim: To study a correlation between lipoprotein(a) [LP(a)], as well as the phenotype of apoprotein(a) [apo(a)] and the presence of intermittent claudication (IC)., Materials and Methods: The study included 25 patients (9 females, 16 males; mean age, 63.4 +/- 8.2 years) and 50 individuals (21 females, 29 males; mean age, 61.3 +/- 6.1 years) of a control group., Results: In the patients, the level of LP(a) was 3 times higher than in the controls (median 39 and 13 mg/dl, respectively; p < 0.01). The low molecular-weight phenotypes of apo(a) occurred significantly more frequently in the patients than those in the controls (62 and 28%, respectively; p = 0.02)., Conclusion: Multifactorial analysis has shown that the level of Lp(a) is an independent and important factor associated with the presence of IC.
- Published
- 2002