[Lipoprotein(a) and Apo-A isoforms in patients with intermittent claudication].

Authors :: Britareva VV
Afanas'eva OI
Dobrovol'skiĭ AB
Ezhov MV
Titaeva EV
Karpov IuA
Pokrovskiĭ SN
Source :: Terapevticheskii arkhiv [Ter Arkh] 2002; Vol. 74 (12), pp. 49-52.
Publication Year :: 2002
Abstract: Aim: To study a correlation between lipoprotein(a) [LP(a)], as well as the phenotype of apoprotein(a) [apo(a)] and the presence of intermittent claudication (IC).<br />Materials and Methods: The study included 25 patients (9 females, 16 males; mean age, 63.4 +/- 8.2 years) and 50 individuals (21 females, 29 males; mean age, 61.3 +/- 6.1 years) of a control group.<br />Results: In the patients, the level of LP(a) was 3 times higher than in the controls (median 39 and 13 mg/dl, respectively; p < 0.01). The low molecular-weight phenotypes of apo(a) occurred significantly more frequently in the patients than those in the controls (62 and 28%, respectively; p = 0.02).<br />Conclusion: Multifactorial analysis has shown that the level of Lp(a) is an independent and important factor associated with the presence of IC.