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Start Over Author "Jyh-Shiun Lin" Topic antioxidant enzymes
2 results on '"Jyh-Shiun Lin"'

1. Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice

Author

Tsung-Hsien Hsu, Shao-Wen Hung, Chun-Yun Wu, Chien-Chao Chiu, Hsin-Tai Hong, Guo-Chi Lee, Chia-Chi Chen, Jyh-Shiun Lin, and Chean-Ping Wu

Subjects
Beef extract, Chemotherapy, Fatigue, Antioxidant enzymes, Nutrition. Foods and food supply, TX341-641
Abstract

Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects.

Published
2020
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2. Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice

Author

Hsin-Tai Hong, Jyh-Shiun Lin, Guo-Chi Lee, Chun-Yun Wu, Chia-Chi Chen, Chien-Chao Chiu, Shao-Wen Hung, Chean-Ping Wu, and Tsung-Hsien Hsu

Subjects
0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Medicine (miscellaneous), 03 medical and health sciences, Grip strength, chemistry.chemical_compound, 0404 agricultural biotechnology, Chemotherapy induced, Internal medicine, Medicine, Chemotherapy, TX341-641, Beef extract, Organ weight, Fatigue, chemistry.chemical_classification, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, Glycogen, business.industry, Nutrition. Foods and food supply, Glutathione peroxidase, 04 agricultural and veterinary sciences, 040401 food science, Endocrinology, chemistry, Catalase, biology.protein, Antioxidant enzymes, business, Food Science
Abstract

Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects.

Published
2020

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