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Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice
- Source :
- Journal of Functional Foods, Vol 75, Iss, Pp 104232-(2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Medicine (miscellaneous)
03 medical and health sciences
Grip strength
chemistry.chemical_compound
0404 agricultural biotechnology
Chemotherapy induced
Internal medicine
Medicine
Chemotherapy
TX341-641
Beef extract
Organ weight
Fatigue
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Glycogen
business.industry
Nutrition. Foods and food supply
Glutathione peroxidase
04 agricultural and veterinary sciences
040401 food science
Endocrinology
chemistry
Catalase
biology.protein
Antioxidant enzymes
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....dc3dfe54e76e2fc35b84eb442573b9ed