1. Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy.
- Author
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Kitada K, Hashiguchi Y, Fukuda T, Yoshida H, Ichimura T, Matsumoto Y, Yasui T, Sumi T, and Ishiko O
- Subjects
- Adult, Aged, Aged, 80 and over, Bridged-Ring Compounds adverse effects, Carboplatin adverse effects, Female, Humans, Japan, Middle Aged, Organoplatinum Compounds adverse effects, Retrospective Studies, Taxoids adverse effects, Young Adult, Antineoplastic Agents adverse effects, Drug Hypersensitivity etiology, Genital Neoplasms, Female drug therapy
- Abstract
Purpose of Investigation: Chemotherapy-related hypersensitivity reaction seems to be problematic in the safe management of chemotherapy. In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy., Methods: Between January 2009 and December 2010, we examined hypersensitivity reaction (> or = grade2) using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. We analyzed the incidence, clinical features, management, and outcome., Results: We administered over 1,057 infusions (24 regimens) to 205 patients. We found a total of four hypersensitivity reactions (> or = grade 2) cases (carboplatin: 2; nedaplatin: 1; docetaxel: 1). Signs and symptoms were varied. In two cases, the same regimen was rechallenged by using anti-allergic drugs. The docetaxel case was successful. The carboplatin case was not successful., Conclusion: Chemotherapy-related hypersensitivity reaction (> or = grade2) does not occur frequently. In the case of platinum, especially, carboplatin, re-administering after hypersensitivity reaction should be done carefully though platinum is a key drug in patients with gynecologic malignancies.
- Published
- 2012