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Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy.
- Source :
-
European journal of gynaecological oncology [Eur J Gynaecol Oncol] 2012; Vol. 33 (3), pp. 252-4. - Publication Year :
- 2012
-
Abstract
- Purpose of Investigation: Chemotherapy-related hypersensitivity reaction seems to be problematic in the safe management of chemotherapy. In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy.<br />Methods: Between January 2009 and December 2010, we examined hypersensitivity reaction (> or = grade2) using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. We analyzed the incidence, clinical features, management, and outcome.<br />Results: We administered over 1,057 infusions (24 regimens) to 205 patients. We found a total of four hypersensitivity reactions (> or = grade 2) cases (carboplatin: 2; nedaplatin: 1; docetaxel: 1). Signs and symptoms were varied. In two cases, the same regimen was rechallenged by using anti-allergic drugs. The docetaxel case was successful. The carboplatin case was not successful.<br />Conclusion: Chemotherapy-related hypersensitivity reaction (> or = grade2) does not occur frequently. In the case of platinum, especially, carboplatin, re-administering after hypersensitivity reaction should be done carefully though platinum is a key drug in patients with gynecologic malignancies.
- Subjects :
- Adult
Aged
Aged, 80 and over
Bridged-Ring Compounds adverse effects
Carboplatin adverse effects
Female
Humans
Japan
Middle Aged
Organoplatinum Compounds adverse effects
Retrospective Studies
Taxoids adverse effects
Young Adult
Antineoplastic Agents adverse effects
Drug Hypersensitivity etiology
Genital Neoplasms, Female drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0392-2936
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of gynaecological oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22873092