1. Induction of antigen cross-presentation by Toll-like receptors.
- Author
-
Datta SK and Raz E
- Subjects
- Animals, CD8-Positive T-Lymphocytes immunology, Cell Differentiation, Cytosol immunology, Dendritic Cells cytology, Dendritic Cells immunology, Histocompatibility Antigens Class I metabolism, Histocompatibility Antigens Class II metabolism, Humans, Ligands, Mice, Toll-Like Receptors, Antigen Presentation, Membrane Glycoproteins immunology, Receptors, Cell Surface immunology
- Abstract
Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.
- Published
- 2005
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