1. Antibody-targeted thrombolytic agents
- Author
-
Thomas Quertermous, Edgar Haber, Christoph Bode, Gary R. Matsueda, and Marshall S Runge
- Subjects
Protein Conformation ,Physiology ,medicine.medical_treatment ,Myocardial Infarction ,Infarction ,Bioinformatics ,Plasminogen Activators ,Fibrinolysis ,Humans ,Medicine ,Thrombolytic Agent ,Thrombolytic Therapy ,Myocardial infarction ,Thrombus ,Chemotherapy ,biology ,business.industry ,medicine.disease ,Recombinant Proteins ,Immunology ,biology.protein ,Antibody ,Cardiology and Cardiovascular Medicine ,business ,Plasminogen activator - Abstract
Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of immunology, molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.
- Published
- 1990