Antibody-targeted thrombolytic agents

Authors :: Thomas Quertermous
Edgar Haber
Christoph Bode
Gary R. Matsueda
Marshall S Runge
Source :: Japanese Circulation Journal. 54:345-353
Publication Year :: 1990
Publisher :: Japanese Circulation Society, 1990.
Abstract: Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of immunology, molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.

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