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Start Over Author "BHASIN, C. P." Topic antibacterial agents
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1. SYNTHESIS AND BIOLOGICAL EVALUATION OF AZITIDINONE AND THEIR DERIVATIVE AS ANTIMICROBIAL AND ANTIFUNGAL AGENTS.

Author

Patel, Chandrakant and Bhasin, C. P.

Subjects
*LACTAMS, *CHEMICAL synthesis, *ANTIFUNGAL agents, *ANTIBACTERIAL agents, *TRIETHYLAMINE, *SCHIFF bases, *QUINOLINE derivatives
Abstract

In our present study 2-Chloro 7-trifluoromethyl 3-Carbaldehydeis condensed with different substituted aromatic amine to form respective Schiff bases. The Schiff bases are cyclized with chloroacetylchloride in triethylamine to yield the corresponding 2-azetidinones. Structures of synthesized compounds are confirmed by physical & spectral analysis. The compounds are evaluated for their antimicrobial and antifungal properties. All the compounds have shown comparable antimicrobial and anti fungal activities. The activities are due to C=O, C-N linkages in 2-azetidinones. [ABSTRACT FROM AUTHOR]

Published
2016

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