SYNTHESIS AND BIOLOGICAL EVALUATION OF AZITIDINONE AND THEIR DERIVATIVE AS ANTIMICROBIAL AND ANTIFUNGAL AGENTS.

In our present study 2-Chloro 7-trifluoromethyl 3-Carbaldehydeis condensed with different substituted aromatic amine to form respective Schiff bases. The Schiff bases are cyclized with chloroacetylchloride in triethylamine to yield the corresponding 2-azetidinones. Structures of synthesized compounds are confirmed by physical & spectral analysis. The compounds are evaluated for their antimicrobial and antifungal properties. All the compounds have shown comparable antimicrobial and anti fungal activities. The activities are due to C=O, C-N linkages in 2-azetidinones. [ABSTRACT FROM AUTHOR]